The current research of the Kurie Laboratory is centered on the investigation of mechanisms of lung cancer metastasis for the purpose of identifying novel therapeutic targets. Of foremost interest is to understand how cellular and extracellular matrix constituents of the tumor microenvironment are controlled by tumor cells and how signals from the microenvironment influence tumor cell behavior.
In this effort, we use cellular models we use cellular models, genetic mouse models of lung cancer that recapitulate key somatic genetic mutations and epigenetic events in tumor cells, and a tissue bank of molecularly and clinically annotated human lung cancers and matched normal lung. The Kurie Laboratory is comprised of postdoctoral fellows, graduate students, and technicians. It is funded by NIH research grants.
The Kurie Laboratory is part of the Department of Thoracic/Head and Neck Medical Oncology at MD Anderson Cancer Center. This Web site contains a research summary for the lab, contact information for all lab members, recent publications, information on requesting reagents, certain lab protocols and photos of social activities.