Kurie Laboratory
The current research of the Kurie Laboratory is centered on the investigation of mechanisms of lung tumorigenesis for the purpose of identifying key genetic and biochemical events required for the transformation of human bronchial epithelial cells. The primary focus is the identification of constitutively active kinase pathways that are required for the survival of lung cancer cells with the long-term goal of developing strategies to target specific kinases or pathways in lung cancer prevention or treatment.
In this effort, we use cellular models (lung cancer cell lines, oncogene-transformed human bronchial epithelial cells lines), mouse models of lung cancer that recapitulate known genetic events, including somatic mutation of KRAS, p53, PTEN and AKT and benign and malignant human lung tissue specimens in a tissue bank with currently over 400 tumors from lung cancer patients. These reagents provide the opportunity to perform high-throughput analysis of gene and protein expression patterns in human and murine tissue samples using state-of-the-art technologies. We investigate the roles of specific genes and their protein products in cellular using gene knock-down by RNAi or shRNA as well as the creation of null or conditional alleles for study in mouse models.
The Kurie Laboratory is comprised of postdoctoral fellows (five), a graduate student, technicians (two) and support staff (one). It is funded by NIH research grants, including R01, P30 (SPORE) and U01 (Mouse Models of Human Cancer) grants. The Kurie Laboratory is part of the Department of Thoracic/Head and Neck Medical Oncology at MD Anderson Cancer Center. This Web site contains a research summary for the lab, contact information for all lab members, recent publications, information on requesting reagents, certain lab protocols and photos of social activities.
Highlights
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Poster Session at AACR 2006
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Denise's Going Away Party 2006
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Dianren's Going Away Party 2006
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Lab Celebration 2006
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Lab Picnic 2004
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Picnicking at the Oil Ranch 2006
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Ridin' at the Oil Ranch 2006
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Swingin' at the Oil Ranch 2006
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Pumpkin Carving 2011
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Pumpkin Carving 2011 -
Pumpkin Carving 2011 -
Pumpkin Carving 2011
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Pumpkin Carving 2011
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Pumpkin Carving 2011
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Pumpkin Carving 2011
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Pumpkin Carving 2011
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Pumpkin Carving 2011
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Pumpkin Carving 2011
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Pumpkin Carving 2011
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Pumpkin Carving 2011
Events
The Kurie Laboratory holds a number of social and academic activities. The following are some of the activities lab members have participated in over the last few years. Some photographs taken at these events can be seen in the slide gallery.
- Pumpkin Carving, Oct. 2011
- Dianren's Going-Away Party
- Oil Ranch, May 2006
- AACR Annual Meeting, April 2006
- Nobu's Going-Away Party, April 2006
- Lab Celebration, February 2006
- Pumpkin Carving Competition, October 2005
- Marie's Going-Away Party, September 2005
- Denise's Going-Away Party, August 2005
- Lab Picnic at Kemah, June 2005
- Lab Picnic, June 2004