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Cancer of the Lung Evaluation and Assessment of Risk (CLEAR)

About the Tool

The CLEAR lung cancer risk prediction tool can quantify a smoker’s risk of developing lung cancer in the next five, 10 or 15 years based on the person’s age, sex, smoking history, medical history, family history of cancer and past exposures to asbestos or wood dust. Information obtained from this risk tool can enable physicians and patients in making decisions about lung cancer screening options.

Our research shows that former and current smokers have varying risks of developing lung cancer depending on their age, sex, whether or not they have been diagnosed with emphysema or hay fever, and their level of exposure to asbestos or wood dusts. We have also found that family history of cancer plays a role in a person’s risk for lung cancer.

Who can use this tool?

The CLEAR tool can be used to predict the risk of lung cancer for any smokers between the ages of 30 and 85.

How was this tool developed?

Researchers in the Department of Epidemiology at The University of Texas MD Anderson Cancer Center and the Kelsey Seybold Foundation developed and tested this lung cancer risk prediction tool. The CLEAR tool is based on data from an ongoing lung cancer case-control study that was supported by the National Cancer Institute since 1991. More detailed information regarding the development of this risk prediction tool can be found in Spitz et al. A risk model for prediction of lung cancer. J Natl Cancer Inst 2007;99:715-726.

Assess Your Risk

Cancer of the Lung Evaluation and Assessment of Risk (CLEAR)

The Lung Cancer Risk Assessment Tool (the Tool) is for general health information purposes only, and not intended to replace professional medical advice, diagnosis or treatment by a qualified health care provider. The Tool cannot predict whether or not you will get lung cancer, instead estimating your odds based upon certain factors. The use of the Tool does not create an express or implied physician-patient relationship and does not obligate MD Anderson to follow-up or contact users of the Tool. MD Anderson assumes no risk or liability for your use of the Tool or information provided therein.

Related Research Materials

Spitz MR, Hong WK, Amos CI, Wu X, Schabath MB, Dong Q, Shete S, Etzel CJ. A risk model for prediction of lung cancer. J Natl Cancer Inst 99(9):715-26, Oct-Dec, 5/2007.

Spitz MR, Etzel CJ, Dong Q, Amos CI, Wei Q, Wu X, Hong WK. An Expanded Risk Prediction Model of Lung Cancer. Cancer Prevention Research 1:250-254, 2008.

Etzel CJ, Kachroo S, Liu M, D'Amelio A, Dong Q, Cote ML, Wenzlaff AS, Hong WK, Greisinger AJ, Schwartz AG, Spitz MR. Development and Validation of a lung cancer risk prediction model for African Americans. Cancer Prevention Research(1(4)):255-265, 2008.

If you have any questions or comments about this risk prediction tool, please contact us at CLEAR@mdanderson.org.


© 2014 The University of Texas MD Anderson Cancer Center