Brain Cancer SPORE Research Projects
| Project 1: Oncolytic Adenoviruses for Glioma Therapy | |
|---|---|
| Frederick Lang, M.D. Clinical Research Co-Leader |
Juan Fueyo, M.D. Basic Biological Sciences Co-Principal Investigator |
Specific Aim 1: Explore the role of autophagy in the synergy of TMZ and viral oncolysis, and develop an autophagy-targeted oncolytic adenovirus.
Specific Aim 2: Assess the safety, efficacy, and biological effects of combining Delta-24-RGD with TMZ in a phase I/II clinical trial.
Specific Aim 3: Validate the effectiveness of bone marrow-derived human mesenchymal stem cells to delivery Delta-24-RGD in preclinical GSC models and in patients with recurrent GBM.
| Project 2: Targeting Metabolic Vulnerabilities with Molecular Inhibitors of Oxidative Phosphorylation | |||
|---|---|---|---|
| Florian Muller, Ph.D. Basic Biological Sciences Co-Leader |
David Piwnica-Worms, Ph.D. Basic Biological Sciences Co-Leader |
John de Groot, M.D. Clinical Research Co-Leader |
Giulio Draetta, M.D., Ph.D. Basic Biological Sciences Co-Leader |
Specific Aim 1: To identify alternative signaling pathways after PI3K inhibition using genomic and proteomic approaches for rational combination therapy.
Specific Aim 2: To develop combinatorial therapies based on subtype-specific targeting of GSCs with PI3K inhibitors in vitro and in vivo.
Specific Aim 3: Design and initiate a multi-arm biomarker-based adaptive randomization combination therapy trial in recurrent glioblastoma.
| Project 3: Deciphering Germline and Somatic Genomic Landscape of Gliomas in Black and Hispanic Minority Groups | ||
|---|---|---|
| Jason Huse, M.D., Ph.D. Basic Biological Sciences Co-Leader |
Melissa Bondy, Ph.D. Basic Biological Sciences Co-Leader |
Christopher Amos, Ph.D. Basic Biological Sciences Co-Leader |
Specific Aim 1: Develop a novel clinical diagnostic to classify patients suitable for FFPE tissue and incorporate the most robust molecular prognostic markers.
Specific Aim 2: Develop a predictive marker of response to radiation therapy.
Brain Cancer SPORE Cores
Core A: Administrative Core
Co-Directors: Frederick Lang, M.D., and Juan Fueyo, M.D.
SPORE Administrator: Biny Joseph, Ph.D.
Purpose: To provide a highly effective and centralized administration for the overall management of the Core in relation to scientific, administrative, financial and interactive aims.
Core B: Pathology and Biorepository Core
Co-Directors: Jason Huse, M.D., Ph.D., Frederick Lang, M.D., and John de Groot, M.D.
Purpose: Collects, processes, and maintains human tissue specimens from patients, and disperses these tissues to SPORE investigators.
Core C: Biostatistics and Bioinformatics Core
Co-Directors: Ying Yuan, Ph.D.
Purpose: To support the clinical and laboratory-based projects of the SPORE grant so that research studies are efficiently designed, conducted, monitored and analyzed.
Core D: Animal Core
Co-Directors: Ganesh Rao, M.D.
Purpose: To provide support for animal models.