Brain Cancer SPORE Research Projects
| Project 1: Oncolytic Adenoviruses for Glioma Therapy | |
|---|---|
| Frederick Lang, M.D. Clinical Research Co-Leader |
Juan Fueyo, M.D. Basic Biological Sciences Co-Principal Investigator |
Specific Aim 1: Test the combination of Delta-24-RGD with anti-PD-1 antibodies in patients with recurrent malignant gliomas.
Specific Aim 2: Assess the safety and biological effects of a next-generation Delta-24-RGD expressing OX40L in patients with recurrent glioma.
Specific Aim 3: Characterize the antiglioma-potency elicited by Delta-24-RGDOX, Delta-24-GREAT, Delta-24-ACT and their combinations.
| Project 2: Off-the-shelf Genetically Engineered Natural Killer Therapy for Glioblastoma | |||
|---|---|---|---|
| Katy Rezvany, M.D., Ph.D. Basic Biological Sciences Co-Leader |
Shiao-Pei Weathers, M.D. Clinical Research Co-Leader |
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Specific Aim 1: To initiate a Phase 1/II study the safety and efficacy of TGF-βR2-/NR3C1-CB-NK cells in relapsed/recurrent GBM.
Specific Aim 2: Study the fate of TGF-βR2-/NR3C1-CB-NK cells and associated immune changes in the CNS and correlate the findings with disease response.
Specific Aim 3: Determine if the membrane-anchored IL-12, IL-21 or IL-15 can further increase the persistence and potency of TGF-βR2-/NR3C1-CB-NK cells against GBM without undue toxicity.
| Project 3: Deciphering Germline and Somatic Genomic Landscape of Gliomas in Black and Hispanic Minority Groups | ||
|---|---|---|
| Jason Huse, M.D., Ph.D. Clinical Research Co-Leader |
Melissa Bondy, Ph.D. Basic Biological Sciences Co-Leader |
Christopher Amos, Ph.D. Basic Biological Sciences Co-Leader |
Specific Aim 1: Characterize the somatic genomic landscape of gliomas in Black and Hispanic patients.
Specific Aim 2: Determine the extent to which racial and ethnic composition in Blacks and Hispanics correlates with disease-defining molecular alterations.
Specific Aim 3: Evaluate the extent to which germline and the somatic variation in Blacks and Hispanics impacts clinical outcome.
Brain Cancer SPORE Cores
Core A: Administrative Core
Co-Directors: Frederick Lang, M.D., and Juan Fueyo, M.D.
SPORE Administrator: Biny Joseph, Ph.D.
Purpose: To provide a highly effective and centralized administration for the overall management of the Core in relation to scientific, administrative, financial and interactive aims.
Core B: Pathology and Biorepository Core
Co-Directors: Jason Huse, M.D., Ph.D., Frederick Lang, M.D., and John de Groot, M.D.
Purpose: Collects, processes, and maintains human tissue specimens from patients, and disperses these tissues to SPORE investigators.
Core C: Biostatistics and Bioinformatics Core
Co-Directors: Ying Yuan, Ph.D.
Purpose: To support the clinical and laboratory-based projects of the SPORE grant so that research studies are efficiently designed, conducted, monitored and analyzed.
Core D: Animal Core
Co-Directors: Betty Kim, M.D., Ph.D., and Sherise Ferguson, M.D.
Purpose: To provide support for animal models.