Selected Publications
Feng T, Luo Q, Liu Y, Jin Z, Skwarchuk D, Lee R, Nam M, Asara JM, Adye DR, Lorenzi PL, Tan L, Pei G, Zhao Z, Zarrin-Khameh N, Paulucci-Holthauzen A, Simons BW, Lee JS, Kopetz S, Yun J. Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD. Nature Metabolism, 2025. e-Pub 2025. PMID: 40973819.
Tsai HY, Chen MH, Yun J, Lai LA, Valentine JF, Bronner MP, Brentnall TA, Pan S, Chen R. Restricting metabolic plasticity enhances stress adaptation through the modulation of PDH and HIF1A in TRAP1-depleted colon cancer. Cancer Lett:217977, 2025. e-Pub 2025. PMID: 40789509.
Zhang C, Yu R, Li S, Yuan M, Hu T, Liu J, Ke H, Ye S, Yun J, Huang J, Liang G, Chen S, Wu X, Lan P. KRAS mutation increases histone H3 lysine 9 lactylation (H3K9la) to promote colorectal cancer progression by facilitating cholesterol transporter GRAMD1A expression. Cell Death Differ, 2025. e-Pub 2025. PMID: 40707783.
Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang SK, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC*, Yun J*. High-fructose corn syrup enhances intestinal tumor growth in mice. Science 363(6433):1345-1349, 2019. e-Pub 2019. (*co-corresponding authors), PMID: 30898933.
Ngo B, Van Riper JM, Cantley LC*, Yun J*. Targeting Cancer Vulnerabilities with High Dose Vitamin C. Nature Reviews Cancer (2019) April 9, Vol 19, p271–282 (*co-corresponding authors).
Shim H, Wu C, Ramsamooj S, Bosch K, Chen Z, Emerling B, Yun J, Liu H, Choo-Wing L, Yang Z, Wulf GM, Kuchroo V, Cantley LC. Deletion of Pip4k2c, a novel phosphatidylinositol kinase results in hyperactivation of the immune system. PNAS (2016) Jul 5;113(27):7596-601.
Yun J, Mullarky E, Lu C, Bosch KN, Kavalier A, Rivera K, Roper J, Chio IIC, Giannopoulou EG, Rago C, Muley A, Asara JM, Paik J, Elemento O, Chen Z, Pappin DJ, Dow LE, Papadopoulos N, Gross SG, Cantley LC. Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. Science (2015) Dec 11;350(6266): 1391-6
Roper J, Sinnamon MJ, Coffee EM, Belmont P, Keung L, Georgeon-Richard L, Wang WV, Faber AC, Yun J, Yilmaz ÖH, Bronson RT, Martin ES, Tsichlis PN, Hung KE. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Lett. (2014) Jun 1;347(2):204-11.
Parkhitko AA, Priolo C, Coloff JL, Yun J, Wu JJ, Mizumura K, Xu W, Malinowska I, Yu J, Kwaitkowski DJ, Brugge JS, Locasale J, Asara J, Choi A, Finkel T, Henske EP. Autophagy-dependent metabolic reprograming leads to pentose phosphate pathway addiction in cells with hyperactive mTORC1. Molecular Cancer Research (2013) Dec 2
Yun J, Johnson JL, Hanigan CL and Locasale JW. Interactions between epigenetics and metabolism in cancers. Frontiers in Molecular and Cellular Oncology. (2012) 2:163. doi: 10.3389
Yun J. Allosteric AKT inhibitors as a targeted cancer therapy. Cancer Biol Ther. (2010) 9(7): 504-506.
Yun J, Rago C, Cheong I, Pagliarini R, Angenendt P, Rajagopalan H, Schmidt K, Wilson JKV, MarkowitzS, Zhou S, Diaz LA, Velculescu V, Lengauer C, Kinzler KW, Vogelstein B, Papadopoulos N. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science (2009) 325 (5947): 1555-9
Lee YJ, Hong KH, Yun J, Oh SP. Generation of activin receptor type IIB isoform-specific hypomorphic alleles. Genesis (2006) 44(10): 487-94
Seki T, Hong KH, Yun J, Kim SJ, Oh SP. Isolation of a regulatory region of activin receptor-like kinase 1 gene sufficient for arterial endothelium-specific expression.Circ Res. (2004) 94(8):72-7
Seki T, Yun J, Oh SP. Arterial endothelium-specific activin receptor-like kinase 1 expression suggests its role in arterialization and vascular remodeling. Circ Res. (2003) 93(7):682-9 Circ Res. (2003) 93(7):682-9
Yun J, Park CW, Lee YJ, Chung JH. Allele-specific methylation in the promoter-associated CpG island of mouse Copg2. Mamm. Genome (2003) 14(6):376-82
Kim J, Hahn Y, Sohn EH, Lee YJ, Yun JH, Kim JM, Chung JH. A phenotypic variation of Thr704Met mutation in skeletal sodium channel gene in a paralysis periodica paramyotonia family. J. Neurol. Neurosurg. Psych. (2001) 70(5):618-623
Lee YJ, Park CW, Hahn Y, Park J, Lee J, Yun JH, Hyun B, Chung JH. Mit1/Lb9and Copg2, new members of mouse imprinted genes closely linked to Peg1/Mest. FEBS Lett. (2000) 472(2-3):230-234
Hahn Y, Lee YJ, Yun JH, Yang SK, Mita K, Huh TL, Rhee M, Chung JH. Duplication of genes encoding non-clathrin coat protein gamma-COP in vertebrate,insect and plant evolution. FEBS Lett. (2000) 482(1-2):31-3