- Colorectal Cancer Research
- Hereditary Cancer Syndrome Research
Welcome to the Vilar Lab website.
Eduardo Vilar, M.D., Ph.D., is an Associate Professor and Deputy Chair in the Department of Clinical Cancer Prevention and is a physician-scientist and medical oncologist by training. His clinical expertise and practice are devoted to the care of patients and families diagnosed with hereditary cancer syndromes with a special emphasis in Lynch Syndrome and Familial Adenomatous Polyposis. Dr. Vilar's long term goal is to contribute to the understanding of colorectal cancer carcinogenesis at the molecular and cellular level and leverage this information to develop novel cancer interception strategies for these genetic conditions. In order to accomplish this overarching goal, his research group has contributed to the characterization of the genomic and transcriptomic landscape of colorectal premalignancy by both using next-generation sequencing and systems biology tools, which has allowed us to identify new genes cooperating in carcinogenesis (e.g. CNOT3), and also identifying novel drug targets for clinical trial implementation (e.g. Naproxen, neoantigens for vaccines). In addition, the Vilar Lab has participated in the development of ex vivo models to better recapitulate the biology of the uninvolved adjacent mucosa and premalignancy. Finally, Dr. Vilar has designed investigator-initiated clinical trials in Lynch Syndrome that have been funded by the National Cancer Institute through the N01 (now UG1) Chemoprevention Consortium for early drug development in prevention.
Dr. Vilar is a Regular Member of the Graduate School of Biomedical Sciences in the Cancer Biology and Quantitative Science programs.
The Vilar Lab is funded through multiple mechanisms such as NIH/NCI (R01, R21, U01, Spore), foundations (SWOG Hope), and generous philanthropic gifts (Feinberg Family Find for Lynch Syndrome research).
The Vilar Laboratory is constantly seeking highly-motivated trainees to work with us at the pre-doctoral and post-doctoral level. Please contact us if interested.
You can follow Vilar on Twitter: @evilarsan.