Below is a listing of recent publications from the Taniguchi Lab. There are many subprojects from each of the publications below that can be devised for rotating students and summer students that can be tailored to each student based on their interests.
Yu, M; Nguyen, N.D.; Huang, Y.; Lin, D.; Fujimoto, T.N.;Molkentine, J.M.; Deorukhkar, A.; Kang, Y.; San Lucas, F.A.; Fernandes, C.J.; Koay, E.J.; Gupta, S., Ying, H.; Koong, A.C.; Herman, J.M.; Fleming, J.B.; Maitra, A.; Taniguchi, C.M.; 2019. Mitochondrial fusion exploits a therapeutic vulnerability of pancreatic cancer. JCI Insight 4, e126915. (Received Cover).
Fujimoto,T.N.; Colbert, L.E.; Molkentine, J.M.; Baseler, L; Deorukhkar A, Kingsley, C.V.; Tailor, R.C.; Sawakuchi, G.O.; Taniguchi, C.M. EGLN Inhibition Reduces Gastrointestinal Radiation Toxicity and Improves Survival in a Murine Model of Locally Advanced Pancreatic Cancer. BioRxiv 195610 [Preprint].
Taniguchi CM, Diep, AN, Miao YR, Wu C, Rankin EB, Atwood TA, Xing L, Giaccia AJ. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Science Translation Medicine, 2014 May 12; 6(236):236ra64 (Received Cover).
Yu, M; Huang, Y; Deorukhkar, A; Fujimoto, TN; Govindaraju, S; Molkentine, JM; Lin, D; Kang, Y; Koay, EJ; Fleming, JB; Gupta, S; Maitra A; Taniguchi, CM. Mitochondrial Fusion Suppresses Pancreatic Cancer Growth via Reduced Oxidative Metabolism. BioRxiv 279745 [Preprint].
Taniguchi CM, Finger EC, Krieg, AJ, Wu, C, Diep AN, LaGory EL, Wei K, McGinnis LC, Yuan J, Kuo CJ, Giaccia AJ. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nature Medicine, 2013 19(10): 1325-1330.
Wei K, Piecewicz S, McGinnis LM, Taniguchi CM, Wiegand S, Chan CW, Mulligan KX, Kuo D, Yuan J, Mortin L, Lefai E, Simon MC, Maher JJ, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A Liver HIF-2 alpha/IRS2 pathway sensitizes insulin signaling and is modulated by VEGF inhibition. Nature Medicine, 2013 19(10): 1331-1337.
Bernard, VB; Semaan, A; Huang, J; San Lucas, FA; Mulu, FC; Stephens, BM; Guerrero, PA; Huang, Y; Zhao, J; Kamyabi, N; Sen, S; Scheet PA; Taniguchi, CM; Kim, MP; Tzeng, CW; Katz MH; Singhi, AD; Maitra, A; Alvarez, HA. Single Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression. BioRxiv 306134 [Preprint].
Huang Y., Lin,D. & Taniguchi, C.M. Sci. China Life Sci. (2017). Hypoxia in the Tumor Microenvironment: Friend or Foe? Published online first: October 13, 2017.
Molkentine, JM; Fujimoto, TN; Horvath, T; Grossberg, AJ; Deorukhkar, A; Samuel, ELG; Chan, WK; Lorenzi, PL; Dantzer, R; Tour, JM; Mason, KA; Taniguchi, CM. Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. BioRxiv 289074 [Preprint].
Colbert, LE; Rebueno, N; Moningi, S; Beddar, S; Sawakuchi GO; Herman JH; Koong AC; Das, P; Holliday EB; Koay EJ; Taniguchi, CM. Dose Escalation for Locally Advanced Pancreatic Cancer: How High Can We Go? BioRxiv 324129 [Preprint]. May 17, 2018 [cited 2018 May 31].
The Taniguchi Lab has protocols for handling murine and human organoids. Find available resources below.
Honors and Awards
Sidney Kimmel Scholar, Sidney Kimmel Foundation
ASCI Young Investigator Award, American Society of Clinical Investigators
Sabin Family Fellow, Andrew Sabin Family Fellowship Program
V Scholar, V Foundation
CPRIT Scholar, Cancer Prevention Research Institute of Texas
McNair Scholar, The Robert and Janice McNair Foundation
MERIT Award, American Society of Clinical Oncology
Barry M Goldwater Scholarship