John A. Tainer, Ph.D.
Robert A. Welch Chair in Chemistry | Professor, Department of Molecular & Cellular Oncology | Director, Structural Biology | CPRIT Scholar | NCI Outstanding Investigator
Areas of Research
- DNA Damage Response
- Cancer Biology
- Breast Cancer
- Prostate Cancer
- Targeted Therapy
Welcome to the Tainer Laboratory
We are located in Molecular and Cellular Oncology at MD Anderson on the 7th and 8th floors of the Basic Science Research Building (BSRB/Mitchell Building). We also use the synchrotron beamline SIBLYS at the Advanced Light Source of the Lawrence Berkeley National Lab (LBNL) that is directed by Dr. Tainer. Academically, our mission is to train the next generation of leading trans-disciplinary scientists for predictive cancer biology. Our core research mission is to develop and apply advanced methods for innovative experiments to define how macromolecular interactomes and assemblies control cell fates and how these interactome networks are altered in cancer and other disease states. We investigate the structural molecular and cellular biology of cancer to develop new strategies, biomarkers and targets for diagnosis and therapy.
Specifically, the Tainer Laboratory focuses upon the development, application and integration of computational and experimental methods and data to define dynamic molecular and cellular mechanisms enabling predictive knowledge that changes how others do their research for:
- Genome stability, instability and cancer
- DNA repair and damage response outcomes
- Mechanisms and interplay of reactive oxygen, DNA damage and immune responses
- Cancer biomarkers and targets with designed inhibitors
We integrate structures (X-ray scattering, crystallography, and EM) with computation and imaging to reveal functional and predictive dynamic assemblies. We test our results by mutations and chemical inhibitors for foundational knowledge advancing biology, biotech and therapeutics.