Linghua Wang Laboratory

The Wang Laboratory focuses mainly on single cell computational biology and immunogenomics. We apply innovative bioinformatics approaches to dissect the tumor ‘ecosystem’ and perform in-depth profiling of the heterogeneous tumor cells and identify distinct immune and stromal cell populations within the tumor immune microenvironment (TIME). Our goal is to advance our scientific understanding of the cellular & molecular cues underlying tumor development / progression, immune suppression and therapy resistance, and translate our novel discoveries into improved patient care. Over the years, we have developed abundant experience in in-depth profiling, highlighting the heterogeneity of tumor cells and cells of the TIME, delineating tumor cells-of-origin and cell lineage diversity / plasticity, and characterizing tumor-immune interactions and evolutionary dynamics by using cutting-edge single cell sequencing technologies, coupled with the state-of-the-art computation and modeling.