Publications

Zhao D, Lu X, Wang G, Lan Z, Liao W, et al. Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer. Nature 542(7642): 484-488, 2017.

 

Boutin AT, Liao WT, Wang M, Hwang SS, Karpinets TV, Cheung H, Chu GC, Jiang S, Hu J, Chang K, Vilar E, Song X, Zhang J, Kopetz S, Futreal A, Wang YA, Kwong LN, DePinho RA. Oncogenic Kras drives invasion and maintains metastases in colorectal cancer. Genes Dev 31(4): 370-382, 2017. 

 

Dey P, Baddour J, Muller F, Wu CC, Wang H, et al.  Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer.  Nature 542(7639): 119-123, 2017.

 

Hu B, Wang Q, Wang YA, Hua S, Sauvé CG, et al.  Epigenetic activation of WNT5A drives glioblastoma stem cell differentiation and invasive growth. Cell 167(5): 1281-1295, 2016.

 

Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, et al.  Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell 27(5): 644-657, 2015. 

 

Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, et al.  Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 488(7411): 337-342, 2012.

 

Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149(3): 656-770, 2012.

 

Hu J, Hwang SS, Liesa M, Gan B, Sahin E, et al.  Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148(4): 651-663, 2012.

 

Ding Z, Wu CJ, Chu GC, Xiao Y, Ho D, et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature. 2011;470 (7333:269–273.)

 

Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470(7334):359-365, 2011.

 

Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, et al. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469(7328):102-106, 2011.

 

Gan B, Hu J, Jiang S, Liu Y, Sahin E, et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468(7324):701-704, 2010.

 

Gan B, Lim C, Chu G, Hua S, Ding Z, et al. FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18(5):472-484, 2010.

 

Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, et al. PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17(5):497-509, 2010.

 

Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, et al. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5(5):540-553, 2009.

 

Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, et al. p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455(7216):1129-1133, 2008

Wang G, Zhao D, Spring DJ, DePinho RA. Genetics and biology of prostate cancer. Genes Dev. 32(17-18):1105-1140, 2018.

 

Zhao D, DePinho RA.  Synthetic essentiality: Targeting tumor suppressor deficiencies in cancer. Bioessays. 39(8), 2017. doi.org/10.1002/bies.201700076

 

Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A, DePinho RA.  Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 30(4): 355-385, 2016.

 

Muller FL, Aquilanti EA, DePinho RA.  Collateral Lethality: A new therapeutic strategy in oncology. Trends Cancer 1(3): 161-173, 2015.

 

Sahin E, DePinho RA. Axis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol. 13(6): 397-404, 2012.

 

Dunn GP, Rinne ML, Wykosky J, Genovese G, Quayle SN, et al. Emerging insights into the molecular and cellular basis of glioblastoma. Genes Dev. 26(8): 756-784, 2012.

 

Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis. 31(1): 9-18, 2010.

 

Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA.  Malignant glioma: genetics and biology of a grave matter. Genes Dev. 15(11): 1311-1333, 2001.

 

DePinho RA. The age of cancer. Nature 408(6809): 248-254, 2000.