Publications

Selected Reviews 

1. Sahin, E and Depinho, RA. (2010). Linking functional decline of telomeres, mitochondria and stem cells during ageing. Nature 464, 520-528.
2. Artandi, SE and Depinho, RA. (2010). Telomeres and telomerase in cancer. Carcinogenesis.
3. Furnari, FB, Fenton, T, Bachoo, RM, Mukasa, A, Stommel, JM, Stegh, A, Hahn, WC, Ligon, KL, Louis, DN, Brennan, C, Chin, L, DePinho, RA and Cavenee, WK. (2007). Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 21, 2683-2710.
4. Hezel, AF, Kimmelman, AC, Stanger, BZ, Bardeesy, N and Depinho, RA. (2006). Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev 20, 1218-1249.

Selected Papers

1. Ying, H, Kimmelman, AC, Lyssiotis, CA, Hua, S, Chu, GC, Fletcher-Sananikone, E, Locasale, JW, Son, J, Zhang, H, Coloff, JL, Yan, H, Wang, W, Chen, S, Viale, A, Zheng, H, Paik, JH, Lim, C, Guimaraes, AR, Martin, ES, Chang, J, Hezel, AF, Perry, SR, Hu, J, Gan, B, Xiao, Y, Asara, JM, Weissleder, R, Wang, YA, Chin, L, Cantley, LC and DePinho, RA. (2012). Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 149, 656-670.

2. Muller, FL, Colla, S, Aquilanti, E, Manzo, VE, Genovese, G, Lee, J, Eisenson, D, Narurkar, R, Deng, P, Nezi, L, Lee, MA, Hu, B, Hu, J, Sahin, E, Ong, D, Fletcher-Sananikone, E, Ho, D, Kwong, L, Brennan, C, Wang, YA, Chin, L and DePinho, RA. (2012). Passenger deletions generate therapeutic vulnerabilities in cancer. Nature 488, 337-342.
3. Lu, X, Agasti, SS, Vinegoni, C, Waterman, P, DePinho, RA and Weissleder, R. (2012). Optochemogenetics (OCG) allows more precise control of genetic engineering in mice with CreER regulators. Bioconjugate chemistry 23, 1945-1951.
4. Hu, J, Hwang, SS, Liesa, M, Gan, B, Sahin, E, Jaskelioff, M, Ding, Z, Ying, H, Boutin, AT, Zhang, H, Johnson, S, Ivanova, E, Kost-Alimova, M, Protopopov, A, Wang, YA, Shirihai, OS, Chin, L and DePinho, RA. (2012). Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell 148, 651-663.
5. Ding, Z, Wu, CJ, Jaskelioff, M, Ivanova, E, Kost-Alimova, M, Protopopov, A, Chu, GC, Wang, G, Lu, X, Labrot, ES, Hu, J, Wang, W, Xiao, Y, Zhang, H, Zhang, J, Zhang, J, Gan, B, Perry, SR, Jiang, S, Li, L, Horner, JW, Wang, YA, Chin, L and DePinho, RA. (2012). Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell 148, 896-907.
6. Chen, AJ, Paik, JH, Zhang, H, Shukla, SA, Mortensen, R, Hu, J, Ying, H, Hu, B, Hurt, J, Farny, N, Dong, C, Xiao, Y, Wang, YA, Silver, PA, Chin, L, Vasudevan, S and Depinho, RA. (2012). STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev 26, 1459-1472.
7. Sahin, E, Colla, S, Liesa, M, Moslehi, J, Muller, FL, Guo, M, Cooper, M, Kotton, D, Fabian, AJ, Walkey, C, Maser, RS, Tonon, G, Foerster, F, Xiong, R, Wang, YA, Shukla, SA, Jaskelioff, M, Martin, ES, Heffernan, TP, Protopopov, A, Ivanova, E, Mahoney, JE, Kost-Alimova, M, Perry, SR, Bronson, R, Liao, R, Mulligan, R, Shirihai, OS, Chin, L and Depinho, RA. (2011). Telomere dysfunction induces metabolic and mitochondrial compromise. Nature 470, 359-365.
8. Ding, Z, Wu, CJ, Chu, GC, Xiao, Y, Ho, D, Zhang, J, Perry, SR, Labrot, ES, Wu, X, Lis, R, Hoshida, Y, Hiller, D, Hu, B, Jiang, S, Zheng, H, Stegh, AH, Scott, KL, Signoretti, S, Bardeesy, N, Wang, YA, Hill, DE, Golub, TR, Stampfer, MJ, Wong, WH, Loda, M, Mucci, L, Chin, L and DePinho, RA. (2011). SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 470, 269-273.
9. Jaskelioff, M, Muller, FL, Paik, JH, Thomas, E, Jiang, S, Adams, AC, Sahin, E, Kost-Alimova, M, Protopopov, A, Cadinanos, J, Horner, JW, Maratos-Flier, E and Depinho, RA. (2011). Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature 469, 102-106.
10. Gan, B, Hu, J, Jiang, S, Liu, Y, Sahin, E, Zhuang, L, Fletcher-Sananikone, E, Colla, S, Wang, YA, Chin, L and Depinho, RA. (2010). Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468, 701-704.
11. Zheng, H, Ying, H, Wiedemeyer, R, Yan, H, Quayle, SN, Ivanova, EV, Paik, JH, Zhang, H, Xiao, Y, Perry, SR, Hu, J, Vinjamoori, A, Gan, B, Sahin, E, Chheda, MG, Brennan, C, Wang, YA, Hahn, WC, Chin, L and DePinho, RA. (2010). PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell 17, 497-509.
12. Stegh, AH, Brennan, C, Mahoney, JA, Forloney, KL, Jenq, HT, Luciano, JP, Protopopov, A, Chin, L and Depinho, RA. (2010). Glioma oncoprotein Bcl2L12 inhibits the p53 tumor suppressor. Genes Dev 24, 2194-2204.
13. Gan, B, Lim, C, Chu, G, Hua, S, Ding, Z, Collins, M, Hu, J, Jiang, S, Fletcher-Sananikone, E, Zhuang, L, Chang, M, Zheng, H, Wang, YA, Kwiatkowski, DJ, Kaelin, WG, Jr., Signoretti, S and DePinho, RA. (2010). FoxOs enforce a progression checkpoint to constrain mTORC1-activated renal tumorigenesis. Cancer Cell 18, 472-484.
14. Paik, JH, Ding, Z, Narurkar, R, Ramkissoon, S, Muller, F, Kamoun, WS, Chae, SS, Zheng, H, Ying, H, Mahoney, J, Hiller, D, Jiang, S, Protopopov, A, Wong, WH, Chin, L, Ligon, KL and DePinho, RA. (2009). FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5, 540-553.
15. Ying, H, Zheng, H, Scott, K, Wiedemeyer, R, Yan, H, Lim, C, Huang, J, Dhakal, S, Ivanova, E, Xiao, Y, Zhang, H, Hu, J, Stommel, JM, Lee, MA, Chen, AJ, Paik, JH, Segatto, O, Brennan, C, Elferink, LA, Wang, YA, Chin, L and DePinho, RA. (2010). Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A 107, 6912-6917.
16. Zheng H, Ying H, Yan H, Kimmelman AC, Hiller DJ, Chen AJ, Perry SR, Tonon G, Chu GC, Ding Z and others. (2008). p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature 455,1129-33.
17. Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, Williams DA, Kwiatkowski DJ, DePinho RA. (2008). mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A 105,19384-9.
18. Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G and others. (2008). Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A 105,19372-7.
19. Stegh AH, Kesari S, Mahoney JE, Jenq HT, Forloney KL, Protopopov A, Louis DN, Chin L, DePinho RA. (2008). Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proc Natl Acad Sci U S A 105,10703-8.
20. Carrasco DR, Sukhdeo K, Protopopova M, Sinha R, Enos M, Carrasco DE, Zheng M, Mani M, Henderson J, Pinkus GS and others. (2007). The differentiation and stress response factor XBP-1 drives multiple myeloma pathogenesis. Cancer Cell 11,349-60.
21. Martin ES, Tonon G, Sinha R, Xiao Y, Feng B, Kimmelman AC, Protopopov A, Ivanova E, Brennan C, Montgomery K and others. (2007). Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res 67,10736-43.
22. Paik JH, Kollipara R, Chu G, Ji H, Xiao Y, Ding Z, Miao L, Tothova Z, Horner JW, Carrasco DR and others. (2007). FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell 128,309-23.
23. Stegh AH, Kim H, Bachoo RM, Forloney KL, Zhang J, Schulze H, Park K, Hannon GJ, Yuan J, Louis DN and others. (2007). Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev 21,98-111.
24. Maser RS, Wong KK, Sahin E, Xia H, Naylor M, Hedberg HM, Artandi SE, DePinho RA. (2007). DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse. Mol Cell Biol 27,2253-65.
25. Sharpless NE, DePinho RA. (2007). How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8,703-13.
26. Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, O'Neil J, Gutierrez A, Ivanova E, Perna I and others. (2007). Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature 447,966-71.
27. Sharpless NE, DePinho RA. (2007). Cancer biology: gone but not forgotten. Nature 445,606-7.
28. Wong KK, Maser RS, Sahin E, Bailey ST, Xia H, Ji H, McNamara K, Naylor M, Bronson RT, Ghosh S and others. (2007). Diminished lifespan and acute stress-induced death in DNA-PKcs-deficient mice with limiting telomeres. Oncogene 26,2815-21.
29. Khoo CM, Carrasco DR, Bosenberg MW, Paik JH, Depinho RA. (2007). Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proc Natl Acad Sci U S A 104,3931-6.
30. Stommel JM, Kimmelman AC, Ying H, Nabioullin R, Ponugoti AH, Wiedemeyer R, Stegh AH, Bradner JE, Ligon KL, Brennan C and others. (2007). Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318,287-90.
31. Carrasco DR, Fenton T, Sukhdeo K, Protopopova M, Enos M, You MJ, Di Vizio D, Nogueira C, Stommel J, Pinkus GS and others. (2006). The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans. Cancer Cell 9,379-90.
32. Carrasco DR, Tonon G, Huang Y, Zhang Y, Sinha R, Feng B, Stewart JP, Zhan F, Khatry D, Protopopova M and others. (2006). High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell 9,313-25.
33. Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, Hezel AF, Horner J, Lauwers GY, Hanahan D and others. (2006). Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 20,3130-46.
34. Farazi PA, DePinho RA. (2006). Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 6,674-87.
35. Sharpless NE, Depinho RA. (2006). The mighty mouse: genetically engineered mouse models in cancer drug development. Nat Rev Drug Discov 5,741-54.
36. Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U and others. (2006). Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A 103,5947-52.
37. Sharpless NE, DePinho RA. (2005). Cancer: crime and punishment. Nature 436,636-7.
38. Tonon G, Wong KK, Maulik G, Brennan C, Feng B, Zhang Y, Khatry DB, Protopopov A, You MJ, Aguirre AJ and others. (2005). High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A 102,9625-30.
39. DePinho RA, Polyak K. (2004). Cancer chromosomes in crisis. Nat Genet 36,932-4.
40. Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA. (2004). Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36,877-82.
41. Attardi LD, DePinho RA. (2004). Conquering the complexity of p53. Nat Genet 36,7-8.
42. Sharpless NE, Ramsey MR, Balasubramanian P, Castrillon DH, DePinho RA. (2004). The differential impact of p16(INK4a) or p19(ARF) deficiency on cell growth and tumorigenesis. Oncogene 23,379-85.
43. Aguirre AJ, Brennan C, Bailey G, Sinha R, Feng B, Leo C, Zhang Y, Zhang J, Gans JD, Bardeesy N and others. (2004). High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A 101,9067-72.
44. Maser RS, DePinho RA. (2003). Take care of your chromosomes lest cancer take care of you. Cancer Cell 3,4-6.
45. Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, Gu Y, Alt FW, DePinho RA. (2003). Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421,643-8.
46. Castrillon DH, Miao L, Kollipara R, Horner JW, DePinho RA. (2003). Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science 301,215-8.
47. O'Hagan RC, Chang S, Maser RS, Mohan R, Artandi SE, Chin L, DePinho RA. (2002). Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell 2,149-55.
48. Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R and others. (2002). Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell 1,269-77.
49. Sharpless NE, Alson S, Chan S, Silver DP, Castrillon DH, DePinho RA. (2002). p16(INK4a) and p53 deficiency cooperate in tumorigenesis. Cancer Res 62,2761-5.
50. Sharpless NE, DePinho RA. (2002). p53: good cop/bad cop. Cell 110,9-12.
51. Maser RS, DePinho RA. (2002). Keeping telomerase in its place. Nat Med 8,934-6.
52. Bardeesy N, DePinho RA. (2002). Pancreatic cancer biology and genetics. Nat Rev Cancer 2,897-909.
53. Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. (2002). Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419,162-7.
54. Maser RS, DePinho RA. (2002). Connecting chromosomes, crisis, and cancer. Science 297,565-9.
55. Rudolph KL, Millard M, Bosenberg MW, DePinho RA. (2001). Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet 28,155-9.
56. Sharpless NE, Bardeesy N, Lee KH, Carrasco D, Castrillon DH, Aguirre AJ, Wu EA, Horner JW, DePinho RA. (2001). Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413,86-91.
57. Kucherlapati R, DePinho RA. (2001). Cancer. Telomerase meets its mismatch. Nature 411,647-8.
58. Sherr CJ, DePinho RA. (2000). Cellular senescence: mitotic clock or culture shock? Cell 102,407-10.
59. DePinho RA. (2000). The age of cancer. Nature 408,248-54.
60. Rudolph KL, Chang S, Millard M, Schreiber-Agus N, DePinho RA. (2000). Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery. Science 287,1253-8.
61. Chin L, Artandi SE, Shen Q, Tam A, Lee SL, Gottlieb GJ, Greider CW, DePinho RA. (1999). p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97,527-38.
62. Greenberg RA, Chin L, Femino A, Lee KH, Gottlieb GJ, Singer RH, Greider CW, DePinho RA. (1999). Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell 97,515-25.
63. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA. (1999). Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96,701-12.
64. Chin L, Tam A, Pomerantz J, Wong M, Holash J, Bardeesy N, Shen Q, O'Hagan R, Pantginis J, Zhou H and others. (1999). Essential role for oncogenic Ras in tumour maintenance. Nature 400,468-72.
65. Pomerantz J, Schreiber-Agus N, Liegeois NJ, Silverman A, Alland L, Chin L, Potes J, Chen K, Orlow I, Lee HW and others. (1998). The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92,713-23.
66. Schreiber-Agus N, Meng Y, Hoang T, Hou H, Jr., Chen K, Greenberg R, Cordon-Cardo C, Lee HW, DePinho RA. (1998). Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth. Nature 393,483-7.
67. Lee HW, Blasco MA, Gottlieb GJ, Horner JW, 2nd, Greider CW, DePinho RA. (1998). Essential role of mouse telomerase in highly proliferative organs. Nature 392,569-74.
68. DePinho RA. (1998). Transcriptional repression. The cancer-chromatin connection. Nature 391,533, 535-6.
69. Alland L, Muhle R, Hou H, Jr., Potes J, Chin L, Schreiber-Agus N, DePinho RA. (1997). Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression. Nature 387,49-55.
70. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. (1996). Role of the INK4a locus in tumor suppression and cell mortality. Cell 85,27-37.
71. Schreiber-Agus N, Chin L, Chen K, Torres R, Rao G, Guida P, Skoultchi AI, DePinho RA. (1995). An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3. Cell 80,777-86.
72. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. (1994). p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 371,72-4.