Research

WU-MDACC Inter-Institutional Molecular Imaging Center
5P50CA094056 15                                             Piwnica-Worms                                        01/01/12 – 12/31/16
NIH/NCI
The goal of this grant is to support a multi-institutional Molecular Imaging Center at Washington University Medical School and MD Anderson Cancer Center.
 

Membrane Permeant Peptides for Imaging Cell Function
5R01EY019587 16                                              Piwnica-Worms                                        09/30/13 – 09/29/17
NIH/NEI
The major goals of this grant are to synthesize and develop novel cell penetrating imaging agents to interrogate intracellular enzyme activities.
 

Employing Mouse Models to Translate Early Detection of Pancreas Cancer
1R01CA195733 01                                             Kalluri/Piwnica-Worms                             07/01/15 – 06/30/18
NIH/NCI
The major goal of this project is to develop minimally invasive MRI combined with novel non-invasive biomarkers measurement on cancer-specific serum exosomes in mouse models to reliably detect early pancreas cancer.
Role: Co-PI
 

Faculty Recruitment Award
Faculty STARS Award                                              Piwnica-Worms                                            01/01/14 – 12/31/16
University of Texas
The major goal of this grant is to purchase equipment and rebuild infrastructure for the laboratory of the PI.
 

Radiome Sequencing of Glioblastoma: Decoding the Imaging Genomic Landscape and Heterogeneity
RSCH11506                                                               Colen                                                               07/01/15 – 06/30/17
Radiological Society of North America
The major goal is to determine and define GBM genomic and imaging intratumoral heterogeneity using precision based-image guided neurosurgical biopsies.
Role: Collaborator; Mentor
 

CIHR Fellowship - Imaging the Changes in Tumor and Stromal Compartments During Short-Tem Starvation in Pancreatic Ductal Adenocarcinoma
338703                                                                        Liu                                                                  07/01/15 – 06/30/18
Canadian Institutes of Health Research
The major goal is to develop a systems-based approach to dissect the relationship between metabolism in tumor versus stroma in intact living pancreatic cancer models to identify mechanisms that regulate pancreatic cancer growth and understand the influence of short term fasting.
Role: Mentor

Targeting KRAS Mutant Lung Cancers
                                                                                Heymach                                                            07/01/15 – 06/30/18
Stand Up 2 Cancer/American Cancer Society
This project develops targeted therapy and immunotherapy approaches to KRAS mutant lung cancers.
Role: Co-Investigator

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized Pyruvate
Koch Functional Imaging and Prostate Cancer Project         Logothetis                                          12/21/15 – 12/20/17
MD Anderson Cancer Center Philanthropy
The major goal of this project is to evaluate sensitivity and specificity of an HP compound for detecting, staging and surveillance of prostate cancer and determining the efficacy of a therapeutic approach.  MD Anderson Cancer Center is in the process of acquiring a clinical hyperpolarizer, SPINLab DNP polarizer, which provides an unprecedented opportunity to realize imaging-based personalized medicine in Texas.
Role: Project Principal Investigator

Interdisciplinary Translational Pre/Postdoctoral Program in Cancer Nanotechnology
1T32CA196561 01                                                                     Sokolov                                                        09/01/15–08/30/20
NIH/NCI
The major goal is to is to enhance the education of the next generation of young scientists in biomedical imaging research using nanotechnologies by combining training in fundamental aspects of nanoscience and nanotechnology with clinical questions faced in cancer imaging and therapy
Role: Mentor

Radiogenomic Screen to Identify Novel Proliferation-associated Glioblastoma Genomic Therapeutic Targets: Discovery and Mechanistic Validation Study
RP160150                                                                                 Colen                                                            03/01/16 – 02/28/19
Cancer Prevention Research Institute of Texas – Individual Investigator Research Award
The major goal is to uncover and validate novel, relevant, and clinically meaningful genomic targets that can be subsequently developed into a therapeutic and more personalized treatment for Glioblastoma
Role: Co-Investigator

Mechanisms of carcinogenesis and therapeutic vulnerabilities associated with RBM10 loss in KRAS mutant NSCLC
W81XWH-15-LCRP-CDA                                                         Skoulidis                                                      06/01/16 – 05/31/18
Department of Defense
The major goal is to investigate the mechanism(s) by which loss of RBM10 promotes KRAS-mutant lung carcinogenesis in cellular and animal models of NSCLC; to determine the clinical correlates of RBM10 inactivation in human LUAC; to develop novel therapeutic strategies for RBM10-deficient NSCLC.
Role: Collaborator