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BY Clayton Boldt, Ph.D.

Stomach and esophageal cancers are diagnosed in more than 40,000 people each year in the U.S. Most of these cases aren’t detected until the cancers are advanced. Unfortunately, available treatment options are not as effective once a cancer becomes metastatic.

Most patients with metastatic stomach or esophageal cancer are treated with combination chemotherapy, but their outcomes can vary widely.

“We select combinations based...

BY Clayton Boldt, Ph.D.

Discovering and developing new treatments for cancer is a difficult process with many obstacles. These challenges can slow the process of...

BY Clayton Boldt, Ph.D.

Targeted therapies are designed to work against specific vulnerabilities in a cancer cell.

The targeted therapy drug venetoclax is...

BY Clayton Boldt, Ph.D.

For patients with pancreatic cancer, the benefits from immunotherapy treatments with immune checkpoint inhibitors or cell therapies have been limited so far. This is partly because pancreatic cancers create an environment that blocks an effective immune response. Also, these tumors have few neoantigens, or mutant proteins, which normally allow the immune system to recognize them as unhealthy cells.

But MD Anderson researchers have...

BY Clayton Boldt, Ph.D.

Last updated on March 23, 2021

Immunotherapy is a treatment option for a growing number of cancers. Unlike traditional treatments like...

BY Clayton Boldt, Ph.D.

Minimal residual disease (MRD) is a term commonly used with blood cancers that describes a small fraction of cancer cells that remain or come...

BY Clayton Boldt, Ph.D.

Layered on top of our genes is an additional set of information -- the epigenome, which is important for many cellular activities. Disruption...

BY Clayton Boldt, Ph.D.

Although a tumor may start from a single cancer cell, it can eventually become millions of cells with unique characteristics. This diversity...

BY Clayton Boldt, Ph.D.

All of the DNA in our cells is organized into complex structures called chromosomes, which consist of our genetic material coiled around many...

BY Clayton Boldt, Ph.D.

In the last decade, immunotherapy has become a viable treatment option for many cancer patients. Unlike radiation and chemotherapy, immunotherapy...