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Multiple Endocrine Neoplasia Symptoms

Symptoms of multiple endocrine neoplasia (MEN) vary from person to person and depend on which glands are affected.

MEN1 Symptoms

  • Hyperparathyroidism, which means the parathyroid gland produces too much hormone. This may cause tiredness, weakness, muscle or bone pain, constipation, kidney stones or thinning of bones. Hyperparathyroidism is usually the first sign of MEN1 and typically occurs between the ages 20 and 25. Nearly 100% of people with MEN1 will develop hyperparathyroidism by the age of 50.
  • High levels of gastrin, ulcers, inflammation of the esophagus, diarrhea and abdominal pain
  • Headaches and changes in vision
  • Problems with sexual function and fertility
  • Acromegaly (enlargement of the bones)
  • Cushing’s syndrome
  • Excess production of breast milk

MEN2B Symptoms

  • Neuromas, which are growths around nerves (neuromas) of mucous membranes, such as the lips and tongue
  • Thickening of the eyelids and lips
  • Abnormalities of bones of feet and thighs
  • Curvature of the spine
  • Long limbs and loose joints
  • Physical characteristics, including being tall and slender
  • Small benign tumors on the lips and tongue
  • Enlargement and irritation of the large intestine

These symptoms do not always mean you have MEN. However, it is important to discuss any symptoms with your doctor, since they may signal other health problems.

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Knowledge Center

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