Faculty Research Interests
Cancer Biology
The genes and processes that affect cancer development.
Chromatin; p53; embryonic stem cells; liver regeneration; breast cancer
Mouse models; tumor suppressor genes; metastasis; stem cells
Human genetics; cancer genetics; familial cancer predisposition; kidney development
Mouse genetics; Hippo pathway; tumor suppressor genes; mouse models for cancer research
Tumor suppressor genes; breast and pancreatic cancer; cancer genetics
Human and molecular genetics; neurogenetics; cancer genetics; genomics
RNA; protein synthesis; Alzheimer's disease; neuronal development
Cell cycle; ubiquitination; 14-3-3 and cancer; gene knock out; p53 signaling
Cellular responses to DNA damage; DNA repair; cell cycle checkpoint signaling
Guillermina (Gigi) Lozano, Ph.D.
Tumor suppressors; mouse models; apoptosis
Connection between normal development and disease; adult and embryonic stem cells; brain tumors; mouse models
Germ cell tumors; biology of germ cells; genetic dissection of disease susceptibility; mouse models
Human cancer; stem cell; mouse models
Single cell genomics; tumor heterogeneity; genome evolution
Cancer epigenetics; histone methylation; stem cells
DNA damage response; genomic instability and cancer; BRCA1 signaling; ubiquitin signaling
Genetics
Study of heredity and the basis for variation in organisms.
RAS-ERK signaling; germ cell development; C. elegans genetics
Mammalian developmental genetics; reproductive biology and disease; stem cells, homeostatis, and regeneration; evolution and development
Ocular development; neural stem cells; brain tumor; mouse molecular genetics
Drosophila genetics; molecular genetics of tissue repair; cell migration; cell signaling and signal transduction; pain sensitization
Organ size control; regeneration; tumor suppressor genes; Drosophila genetics; cancer mechanisms
Human genetics; cancer genetics; familial cancer predisposition; kidney development
Developmental glycobiology; Notch signaling; biliary morphogenesis
Tumor suppressor genes; breast and pancreatic cancer; cancer genetics
Embryo development; transcription factors in development; control of gene expression; gene regulatory networks; stem cell replacement therapy
Human and molecular genetics; neurogenetics; cancer genetics; genomics
Connection between normal development and disease; adult and embryonic stem cells; brain tumors; mouse models
Germ cell tumors; biology of germ cells; genetic dissection of disease susceptibility; mouse models
RNA biology; germ cell development; genetic models of disease
Single cell genomics; tumor heterogeneity; genome evolution
Chromosome dynamics; cell cycle; mitotic kinases; Aurora kinases; C. elegans
Epigenetics; gene expression; DNA repair; aging
Proteomics and Genomics
System-wide changes in proteins and nucleic acids in response to disease and other biological processes.
Howard B. Gutstein, M.D.
Proteomic approaches to addiction and opioid tolerance; interaction of pain and analgesic signal transduction mechanisms; translational pain studies
Human and molecular genetics; neurogenetics; cancer genetics; genomics
Fungal genetics; fungal pathogenesis; signal transduction
Single cell genomics; tumor heterogeneity; genome evolution
DNA damage response; genomic instability and cancer; BRCA1 signaling; ubiquitin signaling
Stem Cells and Developmental Biology
The mechanisms by which cells differentiate and form complex tissues or organ systems.
RAS-ERK signaling; germ cell development; C. elegans genetics
Chromatin; p53; embryonic stem cells; liver regeneration; breast cancer
Mammalian developmental genetics; reproductive biology and disease; stem cells, homeostatis, and regeneration; evolution and development
Cell fate determination; cell differentiation; chondrocytes; osteoblasts
Mouse models; tumor suppressor genes; metastasis; stem cells
Ocular development; neural stem cells; brain tumor; mouse molecular genetics
Drosophila genetics; molecular genetics of tissue repair; cell migration; cell signaling and signal transduction; pain sensitization
Organ size control; regeneration; tumor suppressor genes; Drosophila genetics; cancer mechanisms
Human genetics; cancer genetics; familial cancer predisposition; kidney development
Developmental glycobiology; Notch signaling; biliary morphogenesis
Mouse genetics; Hippo pathway; tumor suppressor genes; mouse models for cancer research
Embryo development; transcription factors in development; control of gene expression; gene regulatory networks; stem cell replacement therapy
Connection between normal development and disease; adult and embryonic stem cells; brain tumors; mouse models
Tissue regeneration; heart disease; mouse genetics; birth defects
Germ cell tumors; biology of germ cells; genetic dissection of disease susceptibility; mouse models
Catenin biology; development; intracellular and nuclear signaling
Chromosome dynamics; cell cycle; mitotic kinases; Aurora kinases; C. elegans
Organ Growth and Cell Signaling
Cellular processes that regulate organ growth and cellular activities.
RAS-ERK signaling; germ cell development; C. elegans genetics
Cell fate determination; cell differentiation; chondrocytes; osteoblasts
Ocular development; neural stem cells; brain tumor; mouse molecular genetics
Drosophila genetics; molecular genetics of tissue repair; cell migration; cell signaling and signal transduction; pain sensitization
Howard B. Gutstein, M.D.
Proteomic approaches to addiction and opioid tolerance; interaction of pain and analgesic signal transduction mechanisms; translational pain studies
Organ size control; regeneration; tumor suppressor genes; Drosophila genetics; cancer mechanisms
Developmental glycobiology; Notch signaling; biliary morphogenesis
Mouse genetics; Hippo pathway; tumor suppressor genes; mouse models for cancer research
Cell-cycle control; signal transduction; Alix functions and regulation
Biophysical analysis; tyrosine kinase signalling; protein complexes; protein-ligand interactions; drug development; structural-thermodynamic correlations
Cellular responses to DNA damage; DNA repair; cell cycle checkpoint signaling
Tissue regeneration; heart disease; mouse genetics; birth defects
Fungal genetics; fungal pathogenesis; signal transduction
Catenin biology; development; intracellular and nuclear signaling
Chromosome dynamics; cell cycle; mitotic kinases; Aurora kinases; C. elegans
Biomolecular Structure and Function
Analysis of the function of macromolecules through structural determination by crystallography and other methods.
Biophysical analysis; tyrosine kinase signalling; protein complexes; protein-ligand interactions; drug development; structural-thermodynamic correlations
Epigenetics; gene expression; DNA repair; aging
Gene Regulation and Epigenetics
The mechanisms by which changes in chromatin structure, transcription, RNA processing and translation are determine patterns of gene expression.
Chromatin; p53; embryonic stem cells; liver regeneration; breast cancer
Cell fate determination; cell differentiation; chondrocytes; osteoblasts
Mouse models; tumor suppressor genes; metastasis; stem cells
Embryo development; transcription factors in development; control of gene expression; gene regulatory networks; stem cell replacement therapy
RNA; protein synthesis; Alzheimer's disease; neuronal development
Guillermina (Gigi) Lozano, Ph.D.
Tumor suppressors; mouse models; apoptosis
RNA biology; germ cell development; genetic models of disease
Fungal genetics; fungal pathogenesis; signal transduction
Catenin biology; development; intracellular and nuclear signaling
Human cancer; stem cell; mouse models
Cancer epigenetics; histone methylation; stem cells
Transcription regulation; TATA-less promoters; chromatin regulation; PARP-1/DNA-PK/TopoIIß complex
Epigenetics; gene expression; DNA repair; aging
DNA damage response; genomic instability and cancer; BRCA1 signaling; ubiquitin signaling