Faculty Research Interests
Genetics, Genomics and Epigenetics
regulation and execution of RAS-ERK signaling; germ cell development; C. elegans genetics
synthetic biology; non-genetic variation; gene regulatory networks; experimental evolution; mechanisms of drug resistance
chromatin; p53; embryonic stem cells; liver regeneration; breast cancer
mammalian developmental genetics; reproductive biology and disease; stem cells, homeostasis, and regeneration; evolution and development
endometrial cancer invasion; identification of novel biomarkers for clinical molecular diagnostics; hereditary endometrial cancer
transcriptional control of cartilage and bone formation; contribution to bone formation by transdifferentiation of chondrocytes; epigenetic control of bone formation
Drosophila genetics; molecular genetics of tissue repair; cell migration; cell signaling and signal transduction; pain sensitization
signal transduction mechanisms underlying narcotic tolerance and dependence; development of more effective methods to treat pain; proteomic approaches to pain, narcotic tolerance, and addiction
human genetics; cancer genetics; familial cancer predisposition; kidney development
mouse genetics; Hippo pathway; tumor suppressor genes; mouse models for cancer research
tumor suppressor genes; breast and pancreatic cancer; cancer genetics
human and molecular genetics; cancer genetics; neurogenetics; genomics; mouse models
RNA; protein synthesis; Alzheimer's disease; neuronal development
Guillermina (Gigi) Lozano, Ph.D.
tumor suppressors; mouse models; apoptosis
tissue regeneration; heart disease; mouse genetics; birth defects
germ cell tumors; biology of germ cells; genetic dissection of cancer susceptibility; mouse models
RNA biology; germ cell development; genetic models of disease
fungal genetics; fungal pathogenesis; signal transduction
human cancer; stem cell; mouse models
single cell genomics; tumor heterogeneity; genome evolution
cell cycle; genome stability; mitotic kinases; Aurora kinases; C. elegans; breast and ovarian cancer
cancer epigenetics; chromatin dynamics; histone modifications; transcription
immunology of skin cancer; MAP kinase pathways in melanoma; genetic basis of skin cancer progression; establishment of skin as a surrogate biomarker
epigenetics; gene expression; DNA repair; aging
Cancer Biology
synthetic biology; non-genetic variation; gene regulatory networks; experimental evolution; mechanisms of drug resistance
endometrial cancer invasion; identification of novel biomarkers for clinical molecular diagnostics; hereditary endometrial cancer
lung development; organ size control; lung cancer
mouse models; tumor suppressor genes; metastasis; stem cells
cell polarity; metastasis; cell adhesion; stem cell biology
mouse genetics; Hippo pathway; tumor suppressor genes; mouse models for cancer research
tumor suppressor genes; breast and pancreatic cancer; cancer genetics
human and molecular genetics; cancer genetics; neurogenetics; genomics; mouse models
cell-cycle control; signal transduction; Alix functions and regulation
cell cycle; ubiquitination; 14-3-3 and cancer; gene knock-out; p53 signaling
cellular responses to DNA damage; DNA repair; cell cycle checkpoint signaling
Guillermina (Gigi) Lozano, Ph.D.
tumor suppressors; mouse models; apoptosis
connection between normal development and disease; adult and embryonic stem cells; brain tumors; mouse models
catenin biology; development; intracellular and nuclear signaling
human cancer; stem cell; mouse models
single cell genomics; tumor heterogeneity; genome evolution
cell cycle; genome stability; mitotic kinases; Aurora kinases; C. elegans; breast and ovarian cancer
cancer epigenetics; chromatin dynamics; histone modifications; transcription
immunology of skin cancer; MAP kinase pathways in melanoma; genetic basis of skin cancer progression; establishment of skin as a surrogate biomarker
DNA damage response; genomic instability and cancer; BRCA1 signaling; ubiquitin signaling
Stem Cells and Development
regulation and execution of RAS-ERK signaling; germ cell development; C. elegans genetics
chromatin; p53; embryonic stem cells; liver regeneration; breast cancer
mammalian developmental genetics; reproductive biology and disease; stem cells, homeostasis, and regeneration; evolution and development
lung development; organ size control; lung cancer
mouse models; tumor suppressor genes; metastasis; stem cells
Drosophila genetics; molecular genetics of tissue repair; cell migration; cell signaling and signal transduction; pain sensitization
cell polarity; metastasis; cell adhesion; stem cell biology
human genetics; cancer genetics; familial cancer predisposition; kidney development
embryo development; transcription factors in development; control of gene expression; gene regulatory networks; stem cell replacement therapy
connection between normal development and disease; adult and embryonic stem cells; brain tumors; mouse models
tissue regeneration; heart disease; mouse genetics; birth defects
germ cell tumors; biology of germ cells; genetic dissection of cancer susceptibility; mouse models
RNA biology; germ cell development; genetic models of disease
catenin biology; development; intracellular and nuclear signaling
Biochemistry and Biomolecular Structure
signal transduction mechanisms underlying narcotic tolerance and dependence; development of more effective methods to treat pain; proteomic approaches to pain, narcotic tolerance, and addiction
RNA; protein synthesis; Alzheimer's disease; neuronal development
cell-cycle control; signal transduction; Alix functions and regulation
biophysical analysis; tyrosine kinase signalling; protein complexes; protein-ligand interactions; drug development; structural-thermodynamic correlations
cell cycle; ubiquitination; 14-3-3 and cancer; gene knock-out; p53 signaling
cellular responses to DNA damage; DNA repair; cell cycle checkpoint signaling
epigenetics; gene expression; DNA repair; aging
DNA damage response; genomic instability and cancer; BRCA1 signaling; ubiquitin signaling