Faculty Research Interests
Cancer Biology
Genes and processes that affect cancer development.
Chromatin; p53; embryonic stem cells; liver
Telomere dysfunction; genomic instability and cancer; molecular biology of aging; molecular cytogenetics analysis of carcinomas; mouse models of aging and cancer
Epigenetics; histone modifying enzymes; genome integrity; mouse development
Mouse models; tumor suppressor genes; metastasis; apoptosis
Human genetics; cancer genetics; familial cancer predisposition; kidney development
Tumor suppressor genes; renal cell carcinoma; cancer genetics
Human and molecular genetics; neurogenetics; cancer genetics; genomics
Cell cycle; ubiquitination; 14-3-3 and cancer; gene knock out; p53 signaling
Cellular responses to DNA damage; DNA repair; cell cycle checkpoint signaling
Guillermina (Gigi) Lozano, Ph.D.
Tumor suppressors; mouse models; apoptosis
Adult and embryonic stem cells; neural/glial tumors; transcriptional regulation; chromatin; mouse models
Germ cell tumors; biology of germ cells; genetic dissection of disease susceptibility; mouse models
Malignancies; stem cell; mouse models
Genomic instability and cancer; epigenetics; histone modification; protein lysine methylation
DNA damage response; genomic instability and cancer; BRCA1 signaling; ubiquitin signaling
Developmental Biology
Studies on how cells differentiate and form complex tissues or organ systems.
Mammalian embryogenesis; reproductive biology and disease; stem cell biology; evolution and development
Genetic control of programmed cell death; apoptosis; cell survival; growth control; signal transduction
Cell fate determination; cell differentiation; chondrocytes; osteoblasts
Organogenesis; secreted signaling molecules; mouse molecular genetics
Drosophila genetics; molecular genetics of tissue repair; cell migration and inflammation; cell signaling and signal transduction; pain sensitization
Growth control; regeneration; tumor suppressor genes; Drosophila genetics
Human genetics; cancer genetics; familial cancer predisposition; kidney development
Developmental glycobiology; Notch signaling; intracellular trafficking; asymmetric divisions
Mouse genetics; pattern formation; development; gene targeting
Embryo development; transcription factors in development; control of gene expression; cell fate specification and differentiation; gene regulatory networks
Adult and embryonic stem cells; neural/glial tumors; transcriptional regulation; chromatin; mouse models
Progenitor/stem cell biology; mouse genetics; birth defects
Alternate RNA splicing; sex determination; animal models for disease
Catenin biology; development; intracellular and nuclear signaling
Chromosome dynamics; mitosis; Aurora kinases; Tousled kinases; C. elegans
Gene Regulation
The mechanisms by which chromatin structure, transcription, RNA processing and translation are regulated.
Chromatin; p53; embryonic stem cells; liver
Multidrug resistance; gene regulation; protein-ligand interaction; X-ray crystallography
Cell fate determination; cell differentiation; chondrocytes; osteoblasts
Epigenetics; histone modifying enzymes; genome integrity; mouse development
Mouse models; tumor suppressor genes; metastasis; apoptosis
Embryo development; transcription factors in development; control of gene expression; cell fate specification and differentiation; gene regulatory networks
Guillermina (Gigi) Lozano, Ph.D.
Tumor suppressors; mouse models; apoptosis
Alternate RNA splicing; sex determination; animal models for disease
Malignancies; stem cell; mouse models
Genomic instability and cancer; epigenetics; histone modification; protein lysine methylation
Transcription regulation; TATA-less promoters; NRF-1; PARP-1; hepatitis B virus
Structural Biology
Analysis of the function of macromolecules through structural determination by crystallography and other methods.
Multidrug resistance; gene regulation; protein-ligand interaction; X-ray crystallography
Biophysical analysis; tyrosine kinase signalling; protein complexes; protein-ligand interactions; drug development; structural-thermodynamic correlations
X-ray crystallography; transcription initiation; transcription regulation; partition; DNA segregation; cell division
Cell Growth and Signaling
Studies on the mechanisms by which cells signal to one another to control their growth, shape, migration and proliferation.
Genetic control of programmed cell death; apoptosis; cell survival; growth control; signal transduction
Telomere dysfunction; genomic instability and cancer; molecular biology of aging; molecular cytogenetics analysis of carcinomas; mouse models of aging and cancer
Organogenesis; secreted signaling molecules; transgenic mice; gene targeting
Drosophila genetics; molecular genetics of tissue repair; cell migration and inflammation; cell signaling and signal transduction; pain sensitization
Howard B. Gutstein, M.D.
Proteomic approaches to addiction and opioid tolerance; interaction of pain and analgesic signal transduction mechanisms
Growth control; regeneration; tumor suppressor genes; Drosophila genetics
Developmental glycobiology; Notch signaling; intracellular trafficking; asymmetric divisions
Mouse genetics; pattern formation; development; gene targeting
Cell-cycle control; signal transduction; Alix functions and regulation
Biophysical analysis; tyrosine kinase signalling; protein complexes; protein-ligand interactions; drug development; structural-thermodynamic correlations
Cell cycle; ubiquitination; 14-3-3 and cancer; gene knock out; p53 signaling
Cellular responses to DNA damage; DNA repair; cell cycle checkpoint signaling
Progenitor/stem cell biology; mouse genetics; birth defects
Fungal genetics; protein kinase; fungal pathogenesis
Catenin biology; development; intracellular and nuclear signaling
Chromosome dynamics; mitosis; Aurora kinases; Tousled kinases; C. elegans
X-ray crystallography; transcription initiation; transcription regulation; partition; DNA segregation; cell division
DNA damage response; genomic instability and cancer; BRCA1 signaling; ubiquitin signaling
Proteomics and Genomics
Studies on the effects of disease and other biological processes on large sets of proteins or genes using microarrays and bioinformatics approaches.
Howard B. Gutstein, M.D.
Proteomic approaches to addiction and opioid tolerance; interaction of pain and analgesic signal transduction mechanisms
Human and molecular genetics; neurogenetics; cancer genetics; genomics
Fungal genetics; protein kinase; fungal pathogenesis