Transgenic Animal Core - Smithville
David Johnson, Ph.D.
Director
Debra Hollowell
Coordinator, Research Laboratory
Genetically engineered mouse models are indispensible tools for studying the function of specific genes and their roles in cancer. The Transgenic Animal Core at Science Park assists investigators in the development and use of genetically engineered mouse models. Since 1996, the core has produced over 175 unique mouse models using traditional transgenic methods as well as zinc-finger nucleases and the current state-of-the-art CRISPR/Cas9 system. These methods allow us to generate transgenic models as well as gene-targeted knock-out and knock-in models at low cost.
Services
- Generation of transgenic mouse founders by pronuclear injection
- Generation of gene-targeted knockout and knock-in mouse lines using zinc finger nucleases or CRISPR/Cas9 technologies
- Re-derivation of specialized mouse lines via embryo transfer or in vitro fertilization using sperm
- Cryopreservation of mouse embryos and sperm for archival storage
- Consultation, technical support and training to investigators wishing to establish genetically modified animals
Contact Us
The Virginia Harris Cockrell Cancer Research Center at the University of Texas MD Anderson Cancer Center, Science Park, Department of Epigenetics and Molecular Carcinogenesis
Mailing Address: P.O. Box 389, Smithville, Texas 78957
Physical Address: 1808 Park Road 1C, Smithville, Texas 78957
David Johnson, Ph.D.
Director, Transgenic Animal Core
Professor, Epigenetics and Molecular Carcinogenesis
Phone: 512-237-9511
Email: djohnson@mdanderson.org
Debra Hollowell
Coordinator, Research Laboratory
Phone: 512-237-9499
Email: dghollow@mdanderson.org