IVIS Spectrum - Multispectral in vivo imaging
The IVIS® Spectrum in vivo imaging system facilitates non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals using bioluminescent and fluorescent reporters across the blue to near infrared wavelength region. It also offers single-view 3D tomography for both fluorescent and bioluminescent reporters that can be analyzed in an anatomical context, and samples can be imaged by either trans-illumination or epi-illumination. Spectral unmixing tools allow the researcher to separate signals from multiple fluorescent reporters within the same animal. It can be used in longitudinal studies to follow disease progression, cancer metastasis and tumor burden/regression within or without the context of therapeutic treatment, as well as many other applications.
Faxitron MX-20 - High-resolution digital radiography
The MX-20 cabinet X-ray is a self-contained, high-throughput system complete with workstation, monitor, mouse and keyboard, enabling rapid, cost-effective efficiently animal monitoring. Scans typically take 12-15 seconds. Samples can be autoexposed or KV and exposure times can be set by the user. The MX-20 has capacity for 5X geometric magnification resulting in ultra-high resolution images. Applications include: phenotyping mutants, monitoring metastasis to bone, and studying bone formation and loss.
Vevo 770 - High frequency ultrasound
The Vevo 770™ micro-imaging platform provides a high-resolution in vivo imaging solution to researchers and helps provide insights into early development of phenotypes as well as responses to therapeutics in vivo. This micro-ultrasound equipment with an axial resolution of 30 µm and a lateral resolution of 75 µm, is well suited for longitudinal studies of diseases such as cancer and is ideal for longitudinal evaluation of tumor size and vascular flow, ultrasound imaging and 3D rendering of tumors.
Aperio ScanScope - Virtual slide preparation: morphometry
The ScanScope scans microscope slides at 20x and 40x magnification. Converting a glass slide to a virtual slide is the basis of digital histology and pathology. The advantages of a virtual slide include: ability for multiple individuals to view and discuss the sample for consultation or analysis, ability to view a slide at different magnifications, easy assembly of collections of related slides and reduced storage requirements combined with easy duplication for backup and data retrieval.
ArcturusXT - Laser capture microdissection
The ArcturusXT microdissection instrument is built around a Nikon Eclipse Ti research microscope with a unique combination of infrared (IR) laser–enabled laser capture microdissection (LCM) and ultraviolet (UV) laser cutting in one platform, thus providing a pathway to analyzing single cells or small cellular sets for microgenomics research. The gentle IR laser and powerful UV laser work in conjunction to efficiently isolate cells without changing morphology or integrity of the biological content. The IR laser helps to capture the cells of interest, and the UV laser microdissects the captured cells. The LCM technique can be used on formalin-fixed, paraffin-embedded (FFPE) sections, frozen tissue sections, and cytological tissue specimens.
The Virginia Harris Cockrell Cancer Research Center
at the University of Texas MD Anderson Cancer Center, Science Park, Department of Epigenetics and Molecular Carcinogenesis
Mailing Address: P.O. Box 389, Smithville, Texas 78957
Physical Address: 1808 Park Road 1C, Smithville, Texas 78957
Manu M. Sebastian, D.V.M., Ph.D., DACVP, DABT, DACLAM
Director, Research Histology, Pathology and Imaging Core
Associate Professor, Epigenetics and Molecular Carcinogenesis
Carlos Perez, D.V.M., Ph.D.
Senior Research Scientist
Digital Pathology and Imaging Services