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Publications
Original Research Articles
Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G. ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Nat Med. 2018 May 7. doi: 10.1038/s41591-018-0012-z. [Epub ahead of print]
Guo DC, Duan XY, Regalado ES, Mellor-Crummey L, Kwartler CS, Kim D, Lieberman K, de Vries BB, Pfundt R, Schinzel A, Kotzot D, Shen X, Yang ML; University of Washington Center for Mendelian Genomics., Bamshad MJ, Nickerson DA, Gornik HL, Ganesh SK, Braverman AC, Grange DK, Milewicz DM. Loss-of-Function Mutations in YY1AP1 Lead to Grange Syndrome and a Fibromuscular Dysplasia-Like Vascular Disease. Am J Hum Genet. 100(1):21-30, 1/2017
Wang X, Chu H, Lv M, Zhang Z, Qiu S, Liu H, Shen X, Wang W, Cai G. Structure of the intact ATM/Tel1 kinase. Nat Commun. 27;7:11655, 5/2016.
Shen J, Peng Y, Wei L, Zhang W, Yang L, Lan L, Kapoor P, Ju Z, Mo Q, Shih IeM, Uray IP, Wu X, Brown PH, Shen X, Mills GB, Peng G. ARID1A Deficiency Impairs the DNA Damage Checkpoint and Sensitizes Cells to PARP Inhibitors. Cancer Discov 5(7):752-67, 7/2015.
Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X. Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Mol Cell. 2015 Jun 4;58(5):863-9, 6/2015.
Kapoor P, Bao Y, Xiao J, Luo J, Shen J, Persinger J, Peng G, Ranish J, Bartholomew B, Shen X. Regulation of Mec1 kinase activity by the SWI/SNF chromatin remodeling complex. Genes Dev 29(6):591-602, 3/2015
Kapoor P, Shen X. Mechanisms of nuclear actin in chromatin-remodeling complexes. Trends Cell Biol 24(4):238-46, 4/2014.
Kapoor P, Chen M, Winkler DD, Luger K and Shen X. Evidence for monomeric actin function in INO80 chromatin remodeling. Nat Struct Mol Biol 20(4):426-432, 04/2013.
Jiang Y, Wang X, Bao S, Guo R, Johnson DG, Shen X, Li L. INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway. Proc Natl Acad Sci U S A 107(40):17274-17279, 10/2010.
Falbo KB, Alabert C, Katou Y, Wu S, Han J, Wehr T, Xiao J, He X, Zhang Z, Shi Y, Shirahige K, Pasero P, Shen X. Involvement of a chromatin remodeling complex in damage tolerance during DNA replication. Nat Struct Mol Biol 16(11):1167-72, 11/2009.
Yu EY, Steinberg-Neifach O, Dandjinou AT, Kang F, Morrison AJ, Shen X, Lue NF. Regulation of telomere structure and functions by subunits of the INO80 chromatin remodeling complex. Mol Cell Biol 27(16):5639-49, 8/2007.
Morrison AJ, Kim JA, Person MD, Highlang J, Xiao J, Wehr TS, Hensley S, Bao Y, Shen J, Collins SR, Weissman JS, Delrow J, Krogan NJ, Haber JE, Shen X. Mec1/Te11 phosphorylation of the INO80 chromatin remodeling complex influences DNA damage checkpoint responses. Cell 130(3):499-511, 8/2007.
Keogh MC, Kim JA, Downey M, Fillingham J, Chowdhury D, Harrison JC, Onishi M, Datta N, Galicia S, Emili A, Lieberman J, Shen X, Buratowski S, Haber JE, Durocher D, Greenblatt JF, Krogan NJ. A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Nature 439(7075):497-501, 1/2006.
Morrison AJ, Highland J, Krogan NJ, Arbel-Eden A, Greenblatt JF, Haber JE, Shen X. INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell 119(6):767-75, 12/2004.
Mizuguchi G, Shen X, Landry J, Wu WH, Sen S, Wu C. ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8, 1/2004. (Co-first author)
Shen X, Ranallo R, Choi E, Wu C. Involvement of actin-related proteins in ATP-dependent chromatin remodeling. Mol Cell 12(1):147-55, 7/2003
Shen X, Xiao H, Ranallo R, Wu WH, Wu C. Modulation of ATP-dependent chromatin-remodeling complexes by inositol polyphosphates. Science 299(5603):112-4, 1/2003.
Rottbauer W, Saurin AJ, Lickert H, Shen X, Burns CG, Wo ZG, Kemler R, Kingston R, Wu C, Fishman M. Reptin and pontin antagonistically regulate heart growth in zebrafish embryos. Cell 111(5):661-72, 11/2002.
Shen X, Mizuguchi G, Hamiche A, Wu C. A chromatin remodelling complex involved in transcription and DNA processing. Nature 406(6795):541-4, 8/2000.
Shen X, Gorovsky MA. Linker histone H1 regulates specific gene expression but not global transcription in vivo. Cell 86(3):475-83, 8/1996.
Shen X, Yu L, Weir JW, Gorovsky MA. Linker histones are not essential and affect chromatin condensation in vivo. Cell 82(1):47-56, 7/1995.
Invited Articles
Kapoor P, Shen X. Stringing Nucleosome Necklaces in the Yeast Genome. Cell. 167(3):600-601, 10/2016
Kapoor P, Shen X. SWI/SNF chromatin remodeling complex regulates a non-chromatin substrate. Cell Cycle 14(15):2379-80, 8/2015
Bao Y, Shen X. SnapShot: Chromatin remodeling: INO80 and SWR1. Cell 144(1):158, 2011.
Falbo KB, Shen X. The tango of histone marks and chaperons at replication fork. Molecular Cell 37:595-596, 2010.
Falbo KB, Shen X. Histone modifications during DNA replication. Mol Cells 28(3):149-54, 9/2009. e-Pub 9/2009.
Morrison AJ, Shen X. Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes. Nat Rev Mol Cell Biol 10(6):373-84, 6/2009. e-Pub 5/2009.
Chen M, Shen X. Nuclear actin and actin-related proteins in chromatin dynamics. Curr Opin Cell Biol 19(3):326-30, 6/2007.
Bao Y, Shen X. SnapShot: chromatin remodeling complexes. Cell 129(3):632, 5/2007.
Bao Y, Shen X. INO80 subfamily of chromatin remodeling complexes. Mutat Res 618(1-2):18-29, 5/2007.
Bao Y, Shen X. Chromatin remodeling in DNA double-strand break repair. Curr Opin Genet Dev 17(2):126-31, 4/2007.
Osley MA, Shen X. Altering nucleosomes during DNA double-strand break repair in yeast. Trends Genet 22(12):671-7, 12/2006.
Bao Y, Shen X. Asf1, a loveseat for a histone couple. Cell 127(3):458-60, 11/2006.
Falbo KB, Shen X. Chromatin remodeling in DNA replication. J Cell Biochem 97(4):684-9, 3/2006.
Morrison AJ, Shen X. DNA repair in the context of chromatin. Cell Cycle 4(4):568-71, 4/2005.
Book Chapters
Kapoor P and Shen X. Chromatin remodeling for DNA repair/replication. In: Cold Spring Habor "Epigenetics", 2013.
Falbo KF and Shen X. Function of the INO80 chromatin remodeling complex in DNA replication. In: Frontier in Bioscience. 17:970-975. Frontier In Bioscience, 2012.
Falbo K, Shen X. Chromatin in DNA damage. In: Molecular Determinants of Radiation Response. Springer, 2011.
Chen M and Shen X. The INO80 chromatin remodeling complex. In: Handbook of Cell Signaling. Elsevier, 2009.
Morrison AJ, Shen X. Linking chromatin modifications to DNA repair. In: Chromatin Dynamics in Cellular Function. Springer-Verlag, 2006.
Shen X. Preparation and analysis of the INO80 complex. In: Methods Enzymol. 377, Chapter 26. Elsevier Inc, 401-12, 2004.