McCrea Laboratory
Pierre D. McCrea, Ph.D.
Principal Investigator
Areas of Research
- Developmental Biology Research
- Gene Expression Research
- Genetics Research
- Molecular Biology Research
- Neurology Research
- Proteomics Research
- Stem Cell Biology Research
- Tumor Suppression Research
Using primary neurons, developing frog embryos and cell lines, we seek to understand the biology of essential catenin proteins. Catenins transduce developmental (e.g. canonical-Wnt pathway) and pathologic signals into the nucleus. Being multi-functional, they further bind and modulate cadherins in regulating cell-cell adhesion at junctions, and influence small-GTPases that determine the behavior of cytoskeletal structures, cell shape and cell movements. Many key interactions and functions of the catenins are yet to be discovered.
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