Marian Kalocsay, Ph.D.
Areas of Research
- Cell Signaling
- Tumor Microenvironment
- Cancer Biology
- Drug Development
- WNT Signaling
The Kalocsay Laboratory is using quantitative mass spectrometry to understand receptor signaling. We have pioneered proximity sensitive proteomics to precisely define functional interactions in situ at unprecedented temporal and spatial resolution and developed proximity phospho-proteomics to precisely follow protein phosphorylation during signaling. We plan to harness these breakthrough technologies to define receptor signaling using experimental models for tumor immune evasion in the future, with the goal of understanding disease mechanisms and developing new therapeutics.
Research Interests: Developing and applying cutting edge mass spectrometry approaches to identify hitherto unknown signaling proteins and ligands and resolve the cascades of localized phosphorylation events in checkpoint signaling.
In the news
Study reveals missing link in mechanisms underlying fight-or-flight response
We are grateful for the generous funding support of our sponsors:
Cancer Prevention and Research Institute of Texas
The University of Texas System Rising STARs
National Institutes of Health
Join Our Lab
Our new lab at MD Anderson is looking for highly motivated postdoctoral research scientists, Ph.D. students and research assistants to elucidate cancer-relevant molecular mechanisms in immune checkpoint signaling. We apply top-notch quantitative multiplexed TMT mass spectrometry with newest instruments for proximity proteomics of receptor signaling and cells in the tumor microenvironment. Come join a great diverse team and help find innovative possible drug targets in cancer therapy.