Curtis Pickering, Ph.D.
Department of Head and Neck Surgery - Research
MD Anderson Cancer Center
TRIUMPH Fellow: 2009-2011
TRIUMPH Mentor: Jeffrey Myers, M.D., Ph.D.
Dr. Pickering earned his B.S. in Biochemistry & Molecular Biology from Michigan State University. He pursued his graduate degree at University of California - San Francisco, where he received his Ph.D. in Cell Biology for his research aimed at understanding the early events in breast carcinogenesis by studying this consequences of p16INK4a inactivation in primary human mammary epithelial cells. He joined the TRIUMPH Postdoctoral Fellowship in 2008 and completed his research on the integrated genomic analysis of head and neck squamous cell carcinoma under the mentorship of Dr. Jeffrey Myers at MD Anderson Cancer Center, where he later earned a faculty position. Dr. Pickering helped lead the first whole exome and integrated genomic studies of head and neck cancer and participated in the subsequent and larger-scale head and neck cancer genomics project from The Cancer Genome Atlas (TCGA).
As an Assistant Professor appointed in the Department of Head & Neck Surgery at MD Anderson, Dr. Pickering continues his research on the translational genomics of head and neck cancer. His research goal is to improving the treatment of head and neck cancer by understanding the genomic alterations that drive the disease. His translational research laboratory utilizes patient samples, patient study data, computational tools, functional genomics, and relevant in vitro and in vivo model systems to characterize genomic alterations and understand their relevance to tumor progression and treatment response. By integrating data across platforms and models their studies span nearly the entire translational spectrum from bedside to bench and back. He now serves as a faculty mentor for the CPRIT Research Training Program.
Dr. Pickering explains “For me the most eye-opening part of the TRIUMPH program was the clinical rotations. They taught me how to communicate and work with physicians and design better translational studies. It was very important for me to see first-hand how patients are treated by physicians. First, I learned the uniqueness of each patient and their own individual disease and treatment path. This demonstrated that any study involving patients will have much more variability than a lab-based study, and there are many more uncontrolled variables in the clinic, so it is inherently more difficult to study patients and patient samples. Second, I learned about the priorities and time-constrains of physicians. Their top priority is the patient, not my research project or even their own research project. Additionally, their options in treating that patient are often limited by practical and ethical concerns. In many instances, the best experimental design cannot actually be performed because the patient has to be treated in a certain way that is in compatible with the research study plan. The ideal translational research project is not only scientifically sound but also clinically feasible, relevant to the treatment of your specific disease, and has a clear translational path to improving patient care. Lots of interesting studies are not realistic or translational.”
Sherry Yen-Yao Wu, Ph.D.
Senior Lecturer, Faculty of Medicine
School of Biomedical Sciences
University of Queensland (Australia)
CPRIT TRIUMPH Fellow: 2011-2015
CPRIT TRIUMPH Mentor: Anil Sood, M.D.
Dr. Wu received her Bachelor's in Pharmacy and later, her Ph.D. from University of Queensland in Australia. Her Ph.D. work focused on delivery of small interfering RNA for cancer treatment. Dr. Wu joined MD Anderson Cancer Center in 2011 as a Postdoctoral Fellow and studied the treatment of ovarian cancer using RNA interference technology. She was especially interested in chemoresistence mechanisms and angiogenesis in this disease. Dr. Wu has a robust and prolific publishing record from her time at MD Anderson and in the CPRIT TRIUMPH Program.
Following her TRIUMPH Postdoctoral Fellowship, Dr. Wu was appointed Research Assistant Professor at MD Anderson, where she continued her work in ovarian cancer. She recently moved home to her native Australia, where she directs the Cancer Therapeutics laboratory and serves on the faculty at University of Queensland. Her research interests focus on developing effective strategies for the detection and treatment of ovarian and breast cancers and to translate these research findings into the clinic. Her current focuses are in harnessing the immune system for cancer therapy, tumor-targeted drug delivery systems, and examining the role(s) of exosomes in cancer progression.
Marco Napoli, Ph.D.
Department of Molecular Oncology (Dr. Elsa Flores Lab)
Moffitt Cancer Center
CPRIT TRIUMPH Fellow: 2014-2016
CPRIT TRIUMPH Mentor: Elsa Flores, Ph.D.
Dr. Napoli earned his B.S. in Biotechnology from the University of Palermo and his M.D. and Ph.D. in Molecular Biomedicine from the University of Triste in his home country of Italy. His PhD work focused on unveiling the mechanisms of action in many b reast cancer promoting factors (ex: Notch1, mutant p53), which act as negative regulators of p63 anti-metastatic functions. He completed his first postdoctoral fellowship at the University of Triste and moved to Texas to work with Dr. Elsa Flores at MD Anderson Cancer Center. Marco joined the TRIUMPH program in 2014 and analyzed p63 isoform-specific transcriptional activities to identify and validate therapeutic targets. He moved to Moffitt Cancer Center with the Flores laboratory in 2016.
Anne M. Bailey, Ph.D.
Clinical Genetics QA Scientist
QIAGEN Bioinformatics (Redwood City, CA, USA)
CPRIT TRIUMPH Fellow 2011-2013
CPRIT TRIUMPH Mentor: Garth Powis, Ph.D.
Dr. Bailey earned her B.S. in Organismal Biology from The University of Kansas and her Ph.D. in Toxicology from The University of Kansas Medical Center. Her Ph.D. dissertation focused on epigenetic regulation of farnesoid x receptor. Relocating to Houston, Dr. Bailey joined the TRIUMPH program in 2011 under the mentorship of Dr. Garth Powis. Here, she studied downregulation of farnesoid x receptor in colorectal cancer and screened novel cellular targets to exploid the unfolded protein response for the treatment of cancer.
Following her post-doctoral fellowship, Dr. Bailey joined the Institute for Personalized Cancer Therapy (IPCT) at MD Anderson as a Precision Oncology Scientist. During her nearly five years in this role, Dr. Bailey assisted in buildling an institutional pipeline for assessing tumor genomic profiles for personalized therapy options. She explains "The TRIUMPH program was a really great netowrking opportunity. I was able to write a phase I clinical trial, which introduced me to clinicians within the Institute for Personalized Cancer Therapy. I was then hired by IPCT as a scientist... This opportunity helped set me up on my current career trajectory."
Diane I. Scaduto, Ph.D.
Scientific Director & Founder
Laboratory Executive Management Leadership
alliantgroup (Houston, TX, USA)
CPRIT TRIUMPH Fellow 2011-2014
CPRIT TRIUMPH Mentor: Lynda Chin, M.D.
Dr. Scaduto completed her B.S. in Biochemistry and Microbiology at UCLA and her Ph.D. in Cell and Molecular Biology from Baylor College of Medicine in 2011, where her dissertation focused on molecular and biochemical characterization of genetic variants and their roles in human cancer. She joined the CPRIT TRIUMPH Postdoctoral Fellowship in Fall 2011 and worked under the mentorship of Dr. Lynda Chin to examine stromal-epithelial metabolic coupling in the melanoma tumor microenvironment.
Dr. Scaduto serves as Founder and Scientific Director for the Laboratory Executive Management Leadership Group in Houston, TX and works as a Scientific Consultant for alliantgroup in Houston. Previously, she served as Scientific Director for Applied Diagnostics, Inc. (Houston, TX) and Scientific Technical Lead for the Houston Forensic Science Center.
Jennifer Dennison, Ph.D.
Associate Director, Research Planning & Development
MD Anderson Cancer Center (Houston, TX, USA)
CPRIT TRIUMPH Fellow: 2009-2014
CPRIT TRIUMPH Mentor: Gordon Mills, M.D., Ph.D.
Dr. Dennison graduated summa cum laude with her B.S. in Chemical Engineering from Texas A&M University. After working in the pharmaceutical industry for a few years, she attended Indiana University, where she earned her Ph.D. in Pharmacology. Dr. Dennison's translational research project was conducted in the Division of Clinical Pharmacy. She hypothesized that expression of CYP3A5, an enzyme with common genetic polymorphisms, may be critical to the hepatic metabolism and ultimately the systemic exposure of vincristine during therapy. Unlike most basic science graduate projects, this project allowed her to collaborate with scientists from Eli Lilly and pediatric oncologists. First, she identified the major cytochrome P450 metabolite of vincristine and characterized its kinetics of biotransformation using recombinant enzymes, human liver microsomes, and cryopreserved hepatocytes. The major metabolite and parent drug were then quantified in plasma from ALL and rhabdomyosarcoma pediatric patients treated with vincristine at Riley Hospital (Indianapolis, IN) and the Children’s Memorial Hospital (Chicago, IL). After evaluating the in vitro findings and the data from these first clinical studies, the Children’s Oncology Group initiated more comprehensive clinical trials to determine whether CYP3A5 genetic polymorphisms were associated with vincristine drug clearance and clinical outcomes. Although the results are unknown at this time, it is anticipated that these trials may justify individualized therapy of vincristine for pediatric oncology patients.
After graduate school, to discover and evaluate new therapies in oncology, Dr. Dennison accepted a post-doctoral fellowship in the Varsha Gandhi laboratory at MD Anderson Cancer Center; this laboratory is proficient in cell culture and molecular biology techniques specific to hematological malignancies and nucleoside analogs. For her project, she evaluated the actions of a new class of nucleoside analogs, the 8-substituted adenosine analogs, using mantle cell lymphoma cell lines and primary cells. In addition, for the on-going phase I clinical trial of 8-chloro-adenosine (8-Cl-Ado) in chronic lymphocytic leukemia, Dr. Dennison determined the ex vivo response of the cells to 8-Cl-Ado and quantified the accumulation of active metabolites in primary cells. She expects that the results of her post-graduate studies will provide justification for future clinical trials of 8-substituted adenosine analogs in MCL and facilitate the understanding of 8-Cl-Ado intracellular metabolism in vivo. Dr. Dennison joined TRIUMPH Postdoctoral Research Fellowship Program and moved to the Department of Systems Biology. Her research here focused on metabolic heterogeneity in breast cancers. While the field of metabolism in oncology at the time almost exclusively focused on the Warburg effect, her research shows that cancers have differences in many key metabolic pathways that are associated with gene expression patterns, the molecular phenotype. Metabolic differences between cancers can be targeted and predict responses to current therapeutics. For example, Dr. Dennison recently evaluated a differentially expressed enzyme, lactate dehydrogenase B, which contributed to the glycolytic phenotype of basal breast cancers and predicted patient response to chemotherapy. She also identified histological markers of luminal breast cancers that contributed to heterogeneous protein expression and subtyping by reverse phase protein array.
Currently serving as the Associate Director for Research Planning and Development for the Red and Charline McCombs Institute for Early Detection and Cancer Treatment at MD Anderson, Dr. Dennison is responsible for the aministrative and scientific leadership of the proteomics and metabolomics platform and clinical studies initiated by the McCombs Institute.
Dr. Dennison reflects "My experience in the TRIUMPH program allowed me to collaborate with clinicians and to understand how laboratory research can influence clinical practice. These experiences are essential to my current position within MD Anderson to lead teams that discover biomarkers for risk assessment and early detection of cancer. I still interact with many of the MD Anderson clinicians whom I met during my fellowship."
Nora Sanchez, Ph.D.
Precision Oncology Scientist
MD Anderson Cancer Center
TRIUMPH Postdoctoral Fellow: 2012-2015
TRIUMPH Program Mentor: Giulio Draetta, M.D., Ph.D.
Dr. Sanchez earned her B.S. in Cell and Molecular Biology from The University of Texas at Austin and her Ph.D. in Pharmacology from Vanderbilt University, where her Ph.D. thesis project focused on understanding the role of type III TGF-b receptor in coronary vessel development. During her time as TRIUMPH Postdoctoral Fellow, Dr. Sanchez led a translational research project to develop a platform for context-specific, functional genomic screens to identify and validate novel therapeutic targets in pancreatic cancer.
Dr. Sanchez joined the Institute for Personalized Cancer Therapy (IPCT) as a Precision Oncology Scientist in 2015 and plans, designs, and delivers requirements to software developers to support the creation and maintenance of informatics platforms to house Precision Oncology Decision Support knowledgebase. She manages collaborations between IPCT and Guardant Health to establish the utility of cfDNA testing in patients with advanced and/or non-biopsable cancers, and she contributes as a subject matter expert to MD Anderson Cancer Center's data governance committee on efforts to standardize and enhace the access and utility of clinical data.
Of the TRIUMPH program, Dr. Sanchez states "The overall diverse training received through TRIUMPH was instrumental to my current position. Specifically, exposure gained through clinical rotations through the various clinics helped develop a key understanding of the bottom line in patient care. Moreover, exposure to the regulatory aspects of clinical research was instrumental to understanding the challenges of moving science from bench to bedside."
Jodi McKenzie, Ph.D.
Clinical Research Scientist
Department of Investigational Cancer Therapeutics (Phase I Clinical Trials)
MD Anderson Cancer Center
TRIUMPH Postdoctoral Fellow: 2013-2016
TRIUMPH Mentor: Patrick Hwu, M.D.
Dr. McKenzie completed her B.A. in Biological Sciences from Mount Holyoke College, where she completed an honors thesis under Dr. Craig T. Woodward titled "The effect of beta-FTZ-F1 mutation on motor neuron structure and function in Drosophila melanogaster." She then earned her Ph.D. in Oncological Sciences from the University of Utah Huntsman Cancer Institute. Here, Dr. McKenzie examined the role of the inhibitor of apoptosis protein Survivin in melanoma cell motility and metastasis. She discovered that Survivin could enhance migration and invasion of melanoma cells through activation of the Akt pathway and upregulation of alpha-5-beta-1 integrin. During her TRIUMPH Postdoctoral Fellowship, she focused on improving melanoma patient response to cancer immunotherapy by developing novel combinations to improve response to T- cell based cancer immunotherapy. Using melanoma patient-derived cell lines and tumor infiltrating lymphocytes (TILs) and in vivo models, she was able to demonstrate that Topoisomerase I inhibitors (Top1) can improve the efficacy of T cell killing of tumor cells. This provided the basis for the development of a clinical trial concept looking at the combination of a Top1 inhibitor and a PD-1/-L1 immune checkpoint inhibitor.
In her current position as Clinical Research Scientist at MD Anderson Cancer Center, Dr. McKenzie works on developing clinical trials focused on combinations of immuno-oncology agents and DNA Damage Response-targeting agents.
Dr. McKenzie says this about our program: "The TRIUMPH program was very instrumental in helping me prepare for my career. Through the program I was able to learn more about human subject research and what’s involved in translating bench research into practical applications in the clinical setting."
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Dong Yang, Ph.D.
Senior Research Scientist
Institute for Personalized Cancer Therapy
MD Anderson Cancer Center
TRIUMPH Postdoctoral Fellow: 2011 - 2015
TRIUMPH Mentor: Lynda Chin, M.D.
Dr. Yang received his B.S. in Biochemistry and M.S. in Cell Biology from Beijing Normal University (Beijing, China). He completed his Ph.D. at Baylor College of Medicine in Biochemistry and Molecular Biology. His dissertation project focused on studying the fucntion of telomere binding proteins and their role in dyskeratosis congenita. Dr. Yang joined the TRIUMPH program in 2011 and investigated targeted therapies for triple-negative breast cancer in preclinical models and utilized NGS to identify biomarkers for therapeutic response.
Following his post-doc, Dr. Yang joined Molecular Health Inc. and worked as a Clinical Science Liaison for two years before returning to his current position at MD Anderson. At the Institute for Personalized Cancer Therapy, Dr. Yang analyzes genomic data and provides personalized medical reports for cancer patients. In his time away from the laboratory, he enjoys playing and reading with his children.
He credits the TRIUMPH program with his career success explaining "The TRIUMPH program exposed me to the field of clinical research through the clinical rotations and curriculum related to clinical trial and human subject research. This program also tremendously helped me establish professional and personal connections, which led me to my current position. Before joining the TRIUMPH program, my understanding of translational cancer research was a linear process from bench to bedside. Now, I realize that translational research should be a two-way proad. The clinical feedback and data are as important as the figures generated in the lab. Without the TRIUMPH program, I would have never found my passion in clinical research and in the job I love."
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