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Rare Ovarian Tumors

While all types of ovarian cancer are uncommon, certain subtypes are extremely rare. About 10% to 15% of ovarian tumors are considered rare, accounting for fewer than 3,500 new cases each year in the United States.

MD Anderson is one of the nation’s leading referral centers for diagnosis and treatment of rare ovarian cancers. As one of the few institutions with specialized experience and expertise in these types of cancer, we offer personalized care, including the most advanced therapies, which may increase your chances for successful treatment.

In addition, we are at the forefront of discovering new and more-effective ways to treat rare ovarian cancers. As a result, we are able to offer clinical trials for several subtypes, including low-grade serous, mucinous, clear cell carcinomas and sex cord stromal tumors . Many of these trials are available at only a few centers in the country.

Each of the following subtypes of ovarian cancer has unique molecular characteristics, and specific treatment is emerging for each subtype. Most are treated with a multi-therapy approach, which may include surgery and chemotherapy, as well as other treatments such as hormonal therapy or targeted therapies.

If you have been diagnosed with a rare ovarian tumor, we’re here to help. Call 1-877-632-6789 to make an appointment or request an appointment online.

Why Choose MD Anderson?

  • Innovative ovarian cancer treatments, including targeted therapies
  • Highly skilled and experienced surgeons
  • Genetic testing for women at high-risk of ovarian cancer
  • Specialized care for rare ovarian cancers
  • Treatment for benign ovarian tumors
  • Nationally recognized ovarian cancer research program with multiple clinical trials
  • Aggressive ovarian cancer is part of MD Anderson's Moon Shots Program: an ambitious effort to reduce cancer deaths through the rapid discovery and implementation of new treatments

Ovarian Cancer Knowledge Center

Treatment at MD Anderson

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Types of Rare Ovarian Cancers

Malignant Ovarian Germ Cell Tumors

  • Dysgerminoma
  • Yolk sac tumor
  • Immature teratoma
  • Embryonal carcinoma
  • Nongestational choriocarcinoma
  • Mixed germ cell tumor

Sex Cord-Stromal Tumors

  • Granulosa cell tumor
  • Sertoli-Leydig cell tumor

Rare Epithelial Ovarian Cancers

  • Clear cell carcinoma
  • Mucinous carcinoma
  • Low-grade serous carcinoma
  • Transitional cell carcinoma
  • Endometrioid carcinoma

Tumors of Low Malignant Potential (Borderline tumors)

  • Carcinosarcoma
  • Small cell carcinoma

© 2014 The University of Texas MD Anderson Cancer Center