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Cancer of Unknown Primary Symptoms

Symptoms of cancer of unknown primary (CUP) vary from person to person and depend on where the cancer has spread. They may include:

  • Swollen lymph nodes that are firm and not painful
  • Mass in the abdomen that can be felt from the outside or causes a feeling of fullness after a small meal
  • Shortness of breath
  • Pain in the chest or abdomen
  • Pain in the bones
  • Skin tumors
  • Fatigue or weakness
  • Lack of appetite or unexplained weight loss

These symptoms do not always mean you have CUP. However, it is important to discuss any symptoms with your doctor, since they may signal other health problems.

If you have been diagnosed with cancer of unknown primary, we can help. Call 1-877-632-6789 to make an appointment or request an appointment online.

Why Choose MD Anderson?

  • Medical oncology and pathology experts with significant experience in evaluating cancer of unknown primary
  • Most-advanced diagnostic methods to pinpoint origin, including leading-edge CT scans and other imaging methods
  • Comprehensive range of renowned specialists to treat cancer when site of origin is found
  • Advanced CUP treatments including proton therapy, targeted therapies and surgery
  • Clinical trials (research studies) of new therapies

CUP Knowledge Center

Treatment at MD Anderson

Cancers of unknown primary are treated in our: 

Gastrointestinal Center by our expert team

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© 2014 The University of Texas MD Anderson Cancer Center