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Publications

Microsatellite Instability and Lynch Syndrome

  1. Vilar E, Scaltriti M, Balmana J, Saura C, Guzman M, Arribas J, Baselga J, Tabernero J. Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines. Br J Cancer. 2008;99(10):1607-12. PMCID: PMC2584960. 
  2. Vilar E, Mukherjee B, Kuick R, Raskin L, Misek DE, Taylor JM, Giordano TJ, Hanash SM, Fearon ER, Rennert G, Gruber SB. Gene Expression Patterns in Mismatch Repair-Deficient Colorectal Cancers Highlight the Potential Therapeutic Role of Inhibitors of the Phosphatidylinositol 3-Kinase-AKT-Mammalian Target of Rapamycin Pathway. Clin Cancer Res 2009;15(8):2829-39. PMCID: PMC3425357. 
  3. Vilar E, Gruber SB Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol. 2010 Mar;7(3):153-62. PMCID: PMC3427139. 
  4. Vilar E, Bartnik CM, Stenzel SL, Raskin L, Ahn J, Moreno V, et al. MRE11 deficiency increases sensitivity to poly(ADP-ribose) polymerase inhibition in microsatellite instable colorectal cancers. Cancer Res. Feb 8 (Epub ahead of print). PMCID: PMC3407272.
  5. Vilar E, Tabernero J. Molecular Dissection of Microsatellite Instable Colorectal Cancer. Cancer Discov 3(5):502-11, 5/2013. e-Pub 3/2013. PMCID: PMC3651752.
  6. Diaz-Padilla I, Romero N, Amir E, Matias-Guiu X, Vilar E, Muggia F, Garcia-Donas J. Mismatch repair status and clinical outcome in endometrial cancer: A systematic review and meta-analysis. Crit Rev Oncol Hematol 88(1):154-67, 10/2013. e-Pub 4/2013.

Clinical Genetics

  1. You YN, Vilar E. Classifying MMR Variants: Time for Revised Nomenclature in Lynch Syndrome. Clin Cancer Res 19(9):2280-2, 5/2013. e-Pub 3/2013.
  2. Bannon SA, Mork M, Vilar E, Peterson SK, Lu K, Lynch PM, Rodriguez-Bigas MA, You YN. Patient-reported disease knowledge and educational needs in Lynch syndrome: findings of an interactive multidisciplinary patient conference. Hered Cancer Clin Pract 12(1):1, 2014. e-Pub 2/2014.
  3. Borras E, Taggart MW, Lynch PM, Vilar E. Establishing a Diagnostic Road Map for MUTYH Associated Polyposis. Clin Cancer Res 20(5):1061-3, 3/2014. e-Pub 1/2014. PMCID:
    PMC3996649.

Molecular Biology of Colorectal Cancer

  1. Dienstmann R, Vilar E, Tabernero J. Molecular predictors of response to chemotherapy in colorectal cancer. Cancer J 17(2):114-26, Mar-Apr, 3/2011.
  2. Vilar E, Perez-Garcia J, Tabernero J. Pushing the envelope in the mTOR pathway: the second generation of inhibitors. Mol Cancer Ther 10(3):395-403, 2011, 3/2011. e-Pub 1/2011. PMCID: PMCPMC3413411.
  3. Vilar E, Tabernero J, Gruber SB. Micromanaging the classification of colon cancer: the role of the microRNAome. Clin Cancer Res 17(23):7207-9, 2011, 12/2011. e-Pub 10/2011. PMCID: PMCPMC3422018.
  4. Vilar E, Tabernero J. Cancer: Pinprick diagnostics. Nature 486(7404):482-3, 6/2012. e-Pub 6/2012.
  5. Goldstein J, Tran B, Ensor J, Gibbs P, Wong HL, Wong SF, Vilar E, Tie J, Broaddus R, Kopetz S, Desai J, Overman MJ. Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H). Ann Oncol 25(5):1032-8, 5/2014. e-Pub 2/2014. PMCID: PMC4072907
  6. Morris VK, San Lucas FA, Overman MJ, Eng C, Morelli MP, Jiang ZQ, Luthra R, Meric-Bernstam F, Maru D, Scheet P, Kopetz S, Vilar E. Clinicopathologic Characteristics and Gene Expression Analyses of Non-KRAS 12/13, RAS-Mutated Metastatic Colorectal Cancer. Ann Oncol pii(mdu252). e-Pub 7/2014

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