Selected Publications

Feser J, Tyler JK. Invited Review, Chromatin structure as a mediator of aging (2011). FEBS letters, published online. PMID: 21081125.

Feser J, Truong D, Das C, Carson JJ, Kieft J, Harkness T, Tyler J. Elevated histone expression promotes life span extension. (2010) Molecular Cell, 39, 724-35. PMID: 20832724.

Das C, Tyler JK, Churchill MEA. Invited Review, The histone shuffle: histone chaperones in an energetic dance. (2010) Trends in Biological Sciences, TIBS 35, 476-89. PMID: 20444609.

Ransom M, Dennehey B, Tyler JK. Chaperoning histones during DNA repair and replication. (2010) Cell 140, 183-195. PMID: 20141833.

Chen C-C, Tyler JK. Selective sensitization of cancer cells to DNA damage by a HAT inhibitor. (2009) Cell Cycle 8(18). PMID: 19736512.

Ransom M, Williams SK, Dechassa ML, Das C, Linger J, Adkins M, Liu C, Bartholomew B, Tyler JK. FACT and the proteasome promote promoter chromatin disassembly and transcriptional initiation. (2009) Journal of Biological Chemistry 284(35): 23461-71. PMID: 19574230.

Ohsawa R, Adkins M, Tyler, JK. Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activators. (2009) Epigenetics and Chromatin 2:11. PMID: 19747370.

Das C, Lucia S, Hansen K., Tyler JK. CBP/p300-mediated acetylation of histone H3 on lysine 56. (2009) Nature 459, 113-117. PMID: 19270680.

Chen C-C, Tyler JK. Chromatin reassembly signals the end of DNA repair. (2008) Cell Cycle, 7, 3792-7. PMID: 19066448.

Chen C-C, Carson J, Feser J, Tamburini B, Zabaronick S, Linger J, Tyler JK. Acetylated lysine 56 on histone H3 drives chromatin assembly after repair and signals for the completion of repair. (2008) Cell, 134, 231-43. PMID: 18662539.

Williams S, Truong D, Tyler JK. Acetylation in the globular core of histone H3 on lysine-56 promotes chromatin disassembly during transcriptional activation. (2008) Proceedings of the National Academy of Science 105, 9000-9005. PMID: 18577595.

Adkins MW, Williams SK, Linger J, Tyler JK. Chromatin disassembly from the PHO5 promoter is essential for the recruitment of the general transcription machinery and coactivators. (2007) Mol Cell Biol. 18, 6372-82. PMID: 7620413.

Linger J, Tyler JK. Chromatin disassembly and assembly during DNA repair. (2007) Mutation Research 618, 52-64. PMID: 17303193.

Williams S, Tyler JK. Transcriptional regulation by chromatin disassembly and reassembly. (2007) Current Opinions in Genetics and Development 17, 88-93. PMID: 17307351.

Adkins MW, Carson JJ, English CM, Ramey JC, Tyler JK. The histone chaperone anti-silencing function 1 stimulates the acetylation of newly synthesized histone H3 in S-phase. (2007) Journal of Biological Chemistry 12, 1334-40. PMID: 17107956.

English CM. Adkins MW. Carson JJ, Churchill MEA, Tyler JK. Structural basis for the histone chaperone activity of Asf1. (2006) Cell 127, 495-508. PMID: 17081973.

Linger J, Tyler JK. Global replication-independent histone H4 exchange in budding yeast. (2006) Eukaryotic Cell 5, 1780-7. PMID: 16936140.

Tamburini B, Carson J, Linger JG, Tyler JK. Dominant mutants of the Saccharomyces cerevisiae ASF1 histone chaperone bypass the need for CAF-1 in transcriptional silencing by altering histone and Sir protein recruitment. (2006) Genetics 173, 599-610. PMID: 16582440.

Adkins MW, Tyler JK. Transcriptional activators are dispensable for transcription in the absence of Spt6-mediated chromatin reassembly of promoter regions. (2006) Molecular Cell 3, 405-416. PMID: 16455495.

Schulz LL, Tyler JK. The histone chaperone ASF1 localizes to active DNA replication forks to mediate efficient DNA replication. (2006) FASEB J 20(3):488-90. PMID: 16396992.

Tyler JK. Chromatin Assembly Methods. (2006) Chapter 38, Cell Biology: a Laboratory Handbook. Edited by Julio E. Celis.

English CM, Maluf NK, Tripet B, Churchill MEA, Tyler JK. ASF1 binds to a heterodimer of histones H3 and H4: a two-step mechanism for the assembly of the H3-H4 heterotetramer on DNA. (2005) Biochemistry 44, 13673-13682. PMID: 16229457.

Tamburini B, Carson J, Adkins M, Tyler JK. Functional conservation and specialization among eukaryotic anti-silencing function 1 histone chaperones. (2005) Eukaryotic Cell 4, 1583-90. PMID: 16151251.

Linger J, Tyler JK. The yeast histone chaperone chromatin assembly factor 1 protects against double-strand DNA-damaging agents. (2005) Genetics 171, 1513-22. PMID: 16143623.

Tamburini B, Tyler JK. Localized histone acetylation and deacetylation triggered by the homologous recombination pathway of double-strand DNA repair. (2005) Molecular and Cellular Biology 25, 4903-4913. PMID: 15923609.

Schulz L, Tyler JK. Heterochromatin focuses on senescence. (2005) Molecular Cell 17, 168-170. PMID: 15664186.

Zabaronick S, Tyler JK. The histone chaperone anti-silencing function 1 is a global regulator of transcription independent of passage through S phase. (2005) Molecular and Cellular Biology 25, 652-660. PMID: 15632066.

Adkins MW, Tyler JK. The histone chaperone Asf1p mediates global chromatin disassembly in vivo. (2004) Journal of Biological Chemistry 279, 52069-52074. PMID: 15452122.

Ramey CJ, Howar S, Adkins M, Linger J, Spicer J, Tyler JK. Activation of the DNA damage checkpoint in yeast lacking the histone chaperone anti-silencing function 1. (2004) Molecular and Cellular Biology 24, 10313-10327. PMID: 15542840.

Adkins M, Howar S, Tyler JK. Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes. (2004) Molecular Cell 14, 657-66. PMID: 15175160.

Tyler JK. Chromatin assembly: cooperation between histone chaperones and ATP-dependent nucleosome remodeling activities. (2002) European Journal of Biochemistry 269, 2268-2274. PMID: 11985607.

Tyler JK*, Collins KA, Prasad-Sinha J, Amiott E, Bulger M, Harte PJ, Kobayashi R, Kadonaga JT. Interaction between the Drosophila CAF-1 and ASF1 chromatin assembly factors. (2001) Molecular and Cellular Biology 21, 6574-6584. *Corresponding author. PMID: 11533245.

Tyler, JK, Adams CR, Chen S-R, Kobayashi R, Kamakaka RT, Kadonaga JT. The RCAF complex mediates chromatin assembly during DNA replication and repair. (1999) Nature 402, 555-560. PMID: 10591219.

Tyler, JK, Kadonaga JT. The "dark side" of chromatin remodeling: repressive effects on transcription. (1999) Cell 99, 443-446. PMID: 10589670.

Tyler JK, Bulger M, Kamakaka RT, Kobayashi R, Kadonaga JT (1996). The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein. Molecular and Cellular Biology 16, 6149-6159. PMID: 8887645.