Lab Members
Current Lab Members
Garth Powis, D.Phil.
Professor and Chair, Department of Experimental Therapeutics
Director, Center for Targeted Therapy
E-mail: gpowis@mdanderson.org
Geoffrey Bartholomeusz, Ph.D.
Assistant Professor
E-mail: gbarthol@mdanderson.org
Projects:
- The thioredoxin system in cancer: Upstream regulators/drug development
- Gene therapy: Utilizing nanotechnology to deliver siRNA into target cells
Geoffrey V. Grandjean
Research Assistant II
E-mail: gvgrandj@mdanderson.org
Project: siRNA screens
Laura Gumbiner-Russo, Ph.D.
Postdoctoral Fellow
E-mail: lgrusso@mdanderson.org
Projects:
- HIF-1-independent mechanisms of tumor cell survival as targets for therapy
- Identifying genes that sensitize hypoxic cells to radiation
Nathan T. Ihle
Program Coordinator
E-mail: ntihle@mdanderson.org
Projects:
- Exploring the interactions in the PI3-K/ AKT/mTOR axis
- Studies with the PI3-K inhibitor PX-866
Brian P. James, Ph.D.
Research Scientist
E-mail: bpjames@MDanderson.org
Project: A genetic approach in Drosophila melanogaster to identify new cancer drug targets
Yon Hui (Sarah) Kim, Ph.D.
Assistant Professor
E-mail: yhkim@mdanderson.org
Projects:
- Identify and elucidate thioredoxin family member roles in cancer cells
- Acetyl/thialysine transferases in the regulation of HIF-1 expression
- Study the differentiation of mesenchymel-derived cell types such as chondrocytes, osteoblasts and adipocytes
John A. Kingston
Senior Research Assistant
E-mail: JAKingst@mdanderson.org
Project: siRNA screens
Mei Yee Koh, Ph.D.
Assistant Professor
E-mail: mykoh@mdanderson.org
Projects:
- Identification of novel co-regulators of the HIF-1/hypoxia response and role in tumorigenesis
- Characterization of molecular functions of HAF, the VHL- and oxygen-independent E3 ubiquitin ligase for HIF-1α
Robert Lemos, Jr.
Sr. Research Assistant
E-mail: rlemos@mdanderson.org
Project: Anti-tumor, pharmacodynamic and pharmacokinetic studies with various cancer types
Susan Mayelzadeh, M.D., Ph.D.
Postdoctoral Fellow
E-mail: smayelzadeh@mdanderson.org
Project: Deciphering the role of microRNAs in hypoxia: Upstream effectors, downstream targets
Sylvestor Moses
Graduate Student
E-mail: smoses@email.arizona.edu
Projects:
- Drug research and development of novel inhibitors targeting the PH domain of Akt
- Identification and development of compounds targeting Tiam-1 to prevent cancer metastasis
Taly R. Spivak-Kroizman, Ph.D.
Assistant Professor
E-mail: tspivakk@mdanderson.org
Project: Redox/ hypoxia regulation of the unfolded protein response (UPR) in cancer
Ryan Watkins, Ph.D.
Instructor
E-mail: rwatkins@mdanderson.org
Project: Determining the structures of PH domains bound to experimental cancer drugs
Alumni
- Elizabeth Clark
Research Assistant I - Dominique R. Cross
Research Assistant I - Chloe N. Franklin
Research Assistant I - Han Sang Kim
College Student
Project: Use of bioinformatics to select HIF-1α regulators in an siRNA screen - Jonathan J. Lu
Research Technician I
Project: A genetic approach in Drosophila melanogaster to identify new cancer drug targets - Laura C. Mengheang
Position: Research Technician I - Ryan Williams
Research Investigator
Project: Use of automated immunohistochemistry (IHC) computer-aided image analysis to support rational drug development