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Selected Publications (from the last 5 years)


  1. You J, Zhang R, Xiong CY, Zhong M, Melancon M, Gupta S, et al. Effective Photothermal Chemotherapy Using Doxorubicin-Loaded Gold Nanospheres That Target EphB4 Receptors in Tumors. Cancer Res. 2012;72(18):4777-86.
  2. Lu W, Xiong CY, Zhang R, Shi LF, Huang M, Zhang GD, et al. Receptor-mediated transcytosis: A mechanism for active extravascular transport of nanoparticles in solid tumors. J Control Release. 2012;161(3):959-66.
  3. Ku G, Zhou M, Song SL, Huang Q, Hazle J, Li C. Copper Sulfide Nanoparticles As a New Class of Photoacoustic Contrast Agent for Deep Tissue Imaging at 1064 nm. Acs Nano. 2012;6(8):7489-96.
  4. Zhang GD, Zhang R, Melancon MP, Wong K, You J, Huang Q, et al. The degradation and clearance of Poly(N-hydroxypropyl-L-glutamine)-DTPA-Gd as a blood pool MRI contrast agent. Biomaterials. 2012;33(21):5376-83.
  5. Gupta S, Stafford RJ, Javadi S, Ozkan E, Ensor JE, Wright KC, et al. Effects of Near-infrared Laser Irradiation of Biodegradable Microspheres Containing Hollow Gold Nanospheres and Paclitaxel Administered Intraarterially in a Rabbit Liver Tumor Model. J Vasc Interv Radiol. 2012;23(4):553-61.
  6. You J, Zhang R, Zhang GD, Zhong M, Liu Y, Van Pelt CS, et al. Photothermal-chemotherapy with doxorubicin-loaded hollow gold nanospheres: A platform for near-infrared light-trigged drug release. J Control Release. 2012;158(2):319-28.
  7. Cao Y, Marks JD, Huang Q, Rudnick SI, Xiong CY, Hittelman WN, et al. Single-Chain Antibody-Based Immunotoxins Targeting Her2/neu: Design Optimization and Impact of Affinity on Antitumor Efficacy and Off-Target Toxicity. Mol Cancer Ther. 2012;11(1):143-53.
  8. Zhao J, Song SL, Zhong M, Li C. Dual-Modal Tumor Imaging via Long-Circulating Biodegradable Core-Cross-Linked Polymeric Micelles. Acs Macro Lett. 2012;1(1):150-3.


  1. Lu W, Melancon MP, Xiong CY, Huang Q, Elliott A, Song SL, et al. Effects of Photoacoustic Imaging and Photothermal Ablation Therapy Mediated by Targeted Hollow Gold Nanospheres in an Orthotopic Mouse Xenograft Model of Glioma. Cancer Res. 2011;71(19):6116-21.
  2. Melancon MP, Elliott A, Ji XJ, Shetty A, Yang Z, Tian M, et al. Theranostics With Multifunctional Magnetic Gold Nanoshells Photothermal Therapy and T2* Magnetic Resonance Imaging. Invest Radiol. 2011;46(2):132-40.
  3. Melancon MP, Elliott AM, Shetty A, Huang Q, Stafford RJ, Li C. Near-infrared light modulated photothermal effect increases vascular perfusion and enhances polymeric drug delivery. J Control Release. 2011;156(2):265-72.
  4. Melancon MP, Li C. Multifunctional Synthetic Poly(L-Glutamic Acid)-Based Cancer Therapeutic and Imaging Agents. Mol Imaging. 2011;10(1):28-42.
  5. Melancon MP, Lu W, Zhong M, Zhou M, Liang G, Elliott AM, et al. Targeted multifunctional gold-based nanoshells for magnetic resonance-guided laser ablation of head and neck cancer. Biomaterials. 2011;32(30):7600-8.
  6. Melancon MP, Zhou M, Li C. Cancer Theranostics with Near-Infrared Light-Activatable Multimodal Nanoparticles. Accounts Chem Res. 2011;44(10):947-56.
  7. Song SL, Xiong CY, Zhou M, Lu W, Huang Q, Ku G, et al. Small-Animal PET of Tumor Damage Induced by Photothermal Ablation with Cu-64-Bis-DOTA-Hypericin. J Nucl Med. 2011;52(5):792-9.
  8. Tian M, Wen XX, Jackson EF, Ng C, Uthamanthil R, Liang D, et al. Pharmacokinetics and magnetic resonance imaging of biodegradable macromolecular blood-pool contrast agent PG-Gd in non-human primates: a pilot study. Contrast Media Mol I. 2011;6(4):289-97.
  9. Wen XX, Lyu MA, Zhang R, Lu W, Huang Q, Liang D, et al. Biodistribution, Pharmacokinetics, and Nuclear Imaging Studies of In-111-labeled rGel/BLyS Fusion Toxin in SCID Mice Bearing B Cell Lymphoma. Mol Imaging Biol. 2011;13(4):721-9.
  10. Xiong CY, Brewer K, Song SL, Zhang R, Lu W, Wen XX, et al. Peptide-Based Imaging Agents Targeting Phosphatidylserine for the Detection of Apoptosis. J Med Chem. 2011;54(6):1825-35.
  11. Xiong CY, Huang MA, Zhang R, Song SL, Lu W, Flores L, et al. In Vivo Small-Animal PET/CT of EphB4 Receptors Using Cu-64-Labeled Peptide. J Nucl Med. 2011;52(2):241-8.
  12. Zhang R, Lu W, Wen XX, Huang M, Zhou M, Liang D, et al. Annexin A5-Conjugated Polymeric Micelles for Dual SPECT and Optical Detection of Apoptosis. J Nucl Med. 2011;52(6):958-64.
  13. Zhang R, Xiong CY, Huang M, Zhou M, Huang Q, Wen XX, et al. Peptide-conjugated polymeric micellar nanoparticles for Dual SPECT and optical imaging of EphB4 receptors in prostate cancer xenografts. Biomaterials. 2011;32(25):5872-9.


  1. Belousova N, Mikheeva G, Xiong CY, Soghomonian S, Young D, Le Roux L, et al. Development of a Targeted Gene Vector Platform Based on Simian Adenovirus Serotype 24. J Virol. 2010;84(19):10087-101.
  2. Li YB, Lu W, Huang QA, Huang MA, Li C, Chen W. Copper sulfide nanoparticles for photothermal ablation of tumor cells. Nanomedicine-Uk. 2010;5(8):1161-71.
  3. Lu W, Huang Q, Geng KB, Wen XX, Zhou M, Guzatov D, et al. Photoacoustic imaging of living mouse brain vasculature using hollow gold nanospheres. Biomaterials. 2010;31(9):2617-26.
  4. Lu W, Zhang GD, Zhang R, Flores LG, Huang Q, Gelovani JG, et al. Tumor Site-Specific Silencing of NF-kappa B p65 by Targeted Hollow Gold Nanosphere-Mediated Photothermal Transfection. Cancer Res. 2010;70(8):3177-88.
  5. Melancon MP, Lu W, Huang QA, Thapa P, Zhou DP, Ng C, et al. Targeted imaging of tumor-associated M2 macrophages using a macromolecular contrast agent PG-Gd-NIR813. Biomaterials. 2010;31(25):6567-73.
  6. Wen X LM, Zhang R, Lu W, Huang Q, Liang D, Rosenblum MG, Li C. . Biodistribution, pharmacokinetics, and nuclear imaging studies of (111)in-labeled rGel/BLyS fusion toxin in SCID mice bearing B bell lymphoma. Mol Imaging Biol 2010;13:721-9.
  7. You J, Shao RP, Wei X, Gupta S, Li C. Near-Infrared Light Triggers Release of Paclitaxel from Biodegradable Microspheres: Photothermal Effect and Enhanced Antitumor Activity. Small. 2010;6(9):1022-31.
  8. You J, Zhang GD, Li C. Exceptionally High Payload of Doxorubicin in Hollow Gold Nanospheres for Near-Infrared Light-Triggered Drug Release. Acs Nano. 2010;4(2):1033-41.
  9. Zhou DP, Wen XX, Thapa P, Liu CW, Hwu P, Li C. L-PG-CpG, a Nanopoymer Formulated Immunomodulator with Enhanced Anticancer Activity. J Immunother. 2010;33(8):915-.
  10. Zhou M, Zhang R, Huang MA, Lu W, Song SL, Melancon MP, et al. A Chelator-Free Multifunctional [Cu-64]CuS Nanoparticle Platform for Simultaneous Micro-PET/CT Imaging and Photothermal Ablation Therapy. J Am Chem Soc. 2010;132(43):15351-8.


  1. Cao W, Bover L, Cho MW, Wen XX, Hanabuchi S, Bao MS, et al. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med. 2009;206(7):1603-14.
  2. Lu W, Xiong CY, Zhang GD, Huang Q, Zhang R, Zhang JZ, et al. Targeted Photothermal Ablation of Murine Melanomas with Melanocyte-Stimulating Hormone Analog-Conjugated Hollow Gold Nanospheres. Clin Cancer Res. 2009;15(3):876-86.
  3. Wang W, Shao RP, Wu QP, Ke S, McMurray J, Lang FF, et al. Targeting Gelatinases with a Near-Infrared Fluorescent Cyclic His-Try-Gly-Phe Peptide. Mol Imaging Biol. 2009;11(6):424-33.
  4. Xiong CY, Lu W, Zhang R, Tian M, Tong W, Gelovani J, et al. Cell-Permeable [Tc-99m(CO3)]-Labeled Fluorogenic Caspase 3 Substrate for Dual-Modality Detection of Apoptosis. Chem-Eur J. 2009;15(36):8979-84.
  5. Xiong CY, Yang Z, Zhang R, Tong W, Gelovani J, Li C. (99m)Tc-labeled Ac-DEVD Peptides as a Substrate for Measuring Caspase Activity. Adv Exp Med Biol. 2009;611:455-6.
  6. Yang Z, Kontoyiannis DP, Wen XX, Xiong CY, Zhang R, Albert ND, et al. Gamma scintigraphy imaging of murine invasive pulmonary aspergillosis with a In-111-labeled cyclic peptide. Nucl Med Biol. 2009;36(3):259-66
  7. Yang Z, Leon J, Martin M, Harder JW, Zhang R, Liang D, et al. Pharmacokinetics and biodistribution of near-infrared fluorescence polymeric nanoparticles. Nanotechnology. 2009;20(16).
  8. Zhang GD, Yang Z, Lu W, Zhang R, Huang Q, Tian M, et al. Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials. 2009;30(10):1928-36.


  1. Frank SJ, Stafford RJ, Bankson JA, Li C, Swanson DA, Kudchadker RJ, et al. A novel MRI marker for prostate brachytherapy. Int J Radiat Oncol. 2008;71(1):5-8.
  2. Li C, Wallace S. Polymer-drug conjugates: Recent development in clinical oncology. Adv Drug Deliver Rev. 2008;60(8):886-98.
  3. Li ML, Oh JT, Xie XY, Ku G, Wang W, Li C, et al. Simultaneous molecular and hypoxia imaging of brain tumors in vivo using spectroscopic photoacoustic tomography. P Ieee. 2008;96(3):481-9.
  4. Melancon MP, Lu W, Yang Z, Zhang R, Cheng Z, Elliot AM, et al. In vitro and in vivo targeting of hollow gold nanoshells directed at epidermal growth factor receptor for photothermal ablation therapy. Mol Cancer Ther. 2008;7(6):1730-9.
  5. Zhang GD, Zhang R, Wen XX, Li L, Li C. Micelles based on biodegradable poly(L-glutamic acid)-b-polylactide with paramagnetic gd ions chelated to the shell layer as a potential nanoscale IVIRI-visible delivery system. Biomacromolecules. 2008;9(1):36-42.

Contact Information

Mailing Address

The University of Texas MD Anderson Cancer Center
Department of Experimental Diagnostic Imaging -- Unit 0059
1515 Holcombe Blvd.
Houston, TX 77030
Phone: 713-792-5182

Lab Locations and Phone Numbers

  • Y5: 713-745-3368
  • Y7: 713-745-3369
  • SB: 713-792-8738                       

© 2014 The University of Texas MD Anderson Cancer Center