Selected Publications

Hamaratoglu F, Gajewski K, Sansores-Garcia L, Morrison C, Tao C, and Halder G. The Hippo tumor suppressor pathway regulates apical domain size in parallel to tissue growth. J Cell Science 122(14), 2009. PMID: 19531584.
(pdf 3.4 MB)

Papa R, Morrison CM, Walters JR, Counterman BA, Chen R, Halder G, Ferguson L, Chamberlain N, Ffrench-Constant R, Kapan DD, Jiggins CD, Reed RD, McMillan WO. Highly conserved gene order and numerous novel repetitive elements in genomic regions linked to wing pattern variation in Heliconius butterflies. BMC Genomics 22(9):345, 7/2008. PMID: 18647405.
(pdf 3.4 MB)

Willecke M, Hamaratoglu F, Sansores-Garcia L, Tao C, Halder G. Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Nat'l Acad Sci USA 105(39):14897-902, 2008. PMID: 18809931.
(pdf 800 KB)

Chamilos G, Lewis RE, Hu J, Xiao L, Zal T, Gilliet M, Halder G, Kontoyiannis DP. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc Nat'l Acad Sci USA 105(27):9367-72, 2008. PMID: 18583479.
(pdf 1.3 MB)

Childress JL, Acar M, Tao C, Halder G. Lethal giant discs, a novel C2-domain protein, restricts notch activation during endocytosis. Curr Biol 16:2228-33, 11/2006. PMID: 17088062.
(pdf 3.3 MB)

Willecke M, Hamaratoglu F, Kango-Singh M, Udan R, Chen CL, Tao C, Zhang X, Halder G. The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 16:2090-100, 11/2006. PMID: 16996265.
(pdf 2.9 MB)

Anbanandam A, Albarado DC, Nguyen CT, Halder G, Gao X. Veeraraghavan S. Insights into Transcription Enhancer Factor 1 (TEF-1) Activity From The Solution Structure of the TEA Domain. Proc Natl Acad Sci USA 103:17225-30, 2006. PMID: 17085591.
(pdf 1.4 MB)

Nolo R, Morrison CM, Tao C, Zhang X, Halder G. The bantam microRNA is a target of the hippo tumor-suppressor pathway. Curr Biol 16:1895-904, 10/2006. PMID: 16949821.
(pdf 1.5 MB)

Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H, Halder G. The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8(1):27-36, 2006. PMID: 16341207.
(pdf 3.0 MB)

Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP, Kango-Singh M, Lu KH, Warneke CL, Atkinson EN, Bedrosian I, Keyomarsi K, Kuo WL, Gray JW, Yin JC, Liu J, Halder G, Mills GB. Atypical PKC iota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci U S A 102(35):12519-24, 8/2005. PMID: 16116079.
(pdf 1.2 MB)

Lionakis MS, Lewis RE, May GS, Wiederhold NP, Albert ND, Halder G, Kontoyiannis DP. Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J Infect Dis 191(7):1188-95, 4/2005. PMID: 15747256.
(pdf 750 KB)

Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 5(10):914-20, 10/2003. PMID: 14502294.
(pdf 1.8 MB)

Kango-Singh M, Halder G. Drosophila as an emerging model to study metastasis. Genome Biol 5(4):216, 2004. PMID: 15059249.
(pdf 100 KB)

Kango-Singh M, Nolo R, Tao C, Verstreken P, Hiesinger PR, Bellen HJ, Halder G. Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila. Development 129(24):5719-30, 12/2002. PMID: 12421711.
(pdf 2.3 MB)

Curtiss J, Halder G, Mlodzik M. Selector and signalling molecules cooperate in organ patterning. Nat Cell Biol 4(3):E48-51, 3/2002. PMID: 11875444.
(pdf 200 KB)

Halder G, Carroll SB. Binding of the Vestigial co-factor switches the DNA-target selectivity of the Scalloped selector protein. Development 128(17):3295-305, 9/2001. PMID: 11546746.
(pdf 750 KB)

Halder G, Polaczyk P, Kraus ME, Hudson A, Kim J, Laughon A, Carroll S. The Vestigial and Scalloped proteins act together to directly regulate wing-specific gene expression in Drosophila. Genes Dev 12(24):3900-9, 12/1998. PMID: 9869643.
(pdf 4.8 MB)

Halder G, Callaerts P, Flister S, Walldorf U, Kloter U, Gehring WJ. Eyeless initiates the expression of both sine oculis and eyes absent during Drosophila compound eye development. Development 125(12):2181-91, 6/1998. PMID: 9584118.
(pdf 500 KB)

Halder G, Callaerts P, Gehring WJ. Induction of ectopic eyes by targeted expression of the eyeless gene in Drosophila. Science 267(5205):1788-92, 3/1995. PMID: 7892602.
(pdf 4.2 MB)