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Publications

Peer-reviewed Articles

Tran MN, Choi W, Wszolek MF, Nayai N, Lee IL, Nitti G, Wen S, Flores ER, Siefker- Radtke A, Czernial B, Dinney C, Barton M, McConkey DJ. The p63 isoform ΔNp63a inhibits epithelial-mesenchymal transition in human bladder cancer cells: Role of miR205. J Biol Chem. 2012 Dec 13. [Epub ahead of print] PMID: 23239884.

Su X, Gi YJ, Chakravarti D, Chan IL, Zhang A, Xia X, Tsai KY, Flores ER. TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metabolism. 2012 Oct 3: 16(4):511-25. PMID: 23040072.

Commentary: 

  1. Burgess DJ. Metabolism: TAp63 tips the energy balance? Nat Rev Cancer. 2012 Nov;12(11):736-7.

Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling. Cell Stem Cell 11(2):179-94, 8/3/2012. PMID: 22862944.

Ahn YH, Gibbons DL, Chakravarti D, Creighton CJ, Rizvi ZH, Adams HP, Pertsemlidis A, Gregory PA, Wright JA, Goodall GJ, Flores ER, Kurie JM. ZEB1 drives prometastatic actin cytoskeletal remodeling by downregulating miR-34a expression. J Clin Invest 2012 Sep 4;122(9):3170-83. PMID: 22850877.

Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling. Cell Stem Cell 11(2):179-94, 8/3/2012. PMID: 22862944.

Wu H, Abou Zeinab R, Flores ER, Leng RP. Pirh2, a Ubiquitin E3 Ligase, Inhibits p73 Transcriptional Activity by Promoting its Ubiquitination. Mol Cancer Res. e-Pub 10/2011. PMID: 21994467.

Mitani Y, Li J, Weber RS, Lippman SL, Flores ER, Caulin C, El-Naggar AK. Expression and regulation of the ΔN and TAp63 isoforms in salivary gland tumorigenesis clinical and experimental findings. Am J Pathol 179(1):391-9, 7/2011. e-Pub 5/2011.PMID: 21703418.

Bornstein C, Brosh R, Molchadsky A, Madar S, Kogan-Sakin I, Goldstein I, Chakravarti D, Flores ER, Goldfinger N, Sarig R, Rotter V. SPATA18, a Spermatogenesis-Associated Gene, Is a Novel Transcriptional Target of p53 and p63. Mol Cell Biol 31(8):1679-89, 4/2011. e-Pub 2/2011. PMID: 21300779.

Su X, Chakravarti D, Cho MS, Liu L, Gi YJ, Lin YL, Leung ML, El-Naggar A, Creighton CJ, Suraokar MB, Wistuba I, Flores ER. TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature 467(7318):986-90, 10/2010. PMID: 20962848.

Commentaries:

  1. Mitchell L. Brothers in arms against cancer. Vol.331 no. 6024, 1551-1552. Science March 25 2011.
  2. Alderton G.K. Tumor suppression: The burning issue of p63. Nature Reviews Cancer 10, 814-815 (December 2010).
  3. Valastyan, S. and Weinberg, R. Metastasis suppression: The role of Dice(r). Genome Biology 2010, 11:141.
  4. Faculty of 1000 – rated 8 (Laura Attardi, Ph.D., Associate Professor, Stanford University)

Cho MS, Chan IL, Flores ER. DeltaNp63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis. Cell Cycle 9(12). e-Pub 6/2010. PMID: 20519941.

Commentary:

  1. Sinha S. Breaking into the Brachury world: ΔNp63 joins in. Cell Cycle News and Views, 2489-2499, July 1 2010.

Lin Y-L, Sengupta S, Gurdziel K, Bell, G, Jacks T, and Flores ER. p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genetics 5(10):e1000680, 10/2009. e-Pub 10/2009. PMID: 19816568.

Su X, Cho MS, Gi YJ, Ayanga BA, Sherr CJ, Flores ER. Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J 28(13):1904-15, 7/8/2009. e-Pub 6/4/2009. PMID: 19494829.

Su X, Paris M, Gi Y-J, Tsai KY, Cho MS, Lin Y-L, Biernaskie JA, Sinha S, Prives C, Pevny LH, Miller FD, and Flores ER. TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell 5(1):64-75, 7/2009. PMID: 19570515.

Commentary:

  1. Beaudry, V.G. and Attardi L.D. SKP-ing TAp63: Stem Cell Depletion, Senescence and Premature Aging. Cell Stem Cell, 1-2, 2 July 2009.

Talos F, Nemajerova A, Flores ER, Petrenko O, and Moll U. p73 suppresses polyploidy and aneuploidy in the absence of functional p53. Mol Cell 27(4):647-659, 8/2007. PMID: 17707235.

Flores ER, Sengupta S, Miller JB, Newman JJ, Bronson R, Crowley D, Yang A, McKeon F, Jacks T. Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell 7(4):363-73, 4/2005. PMID: 15837625.

Reczek EE, Flores ER, Tsay AS, Attardi LD, Jacks T. Multiple response elements and differential p53 binding control Perp expression during apoptosis. Mol Cancer Res 1(14):1048-57, 12/2003. PMID: 14707288.

Flores ER, Tsai KY, Crowley D, Sengupta S, Yang A, McKeon F, Jacks T. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage. Nature 416(6880):560-4, 4/2002. PMID: 11932750.

Commentaries:

  1. Urist M. and Prives C. p53 leans on its siblings. Cancer Cell, 311-313, 1 May 2002
  2. Mitchell A. Apoptosis: The p53 mafia. Nature Reviews Cancer 2, 326 (May 2002)
  3. Faculty of 1000 – rated 6 (William Kaelin, M.D., Professor, Harvard Medical School, Dana Farber Cancer Institute)

de Vries A, Flores ER, Miranda B, Hsieh HM, van Oostrom CT, Sage J, Jacks T. Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function. Proc Natl Acad Sci U S A 99(5):2948-53, 3/2002. PMID: 11867759.

Duensing S, Duensing A, Flores ER, Do A, Lambert PF, Munger K. Centrosome abnormalities and genomic instability by episomal expression of human papillomavirus type 16 in raft cultures of human keratinocytes. J Virol 75(16):7712-6, 8/2001. PMID: 11462043.

Irwin M, Marin MC, Phillips AC, Seelan RS, Smith DI, Liu W, Flores ER, Tsai KY, Jacks T, Vousden KH, Kaelin WG, Jr. Role for the p53 homologue p73 in E2F-1-induced apoptosis. Nature 407(6804):645-8, 10/2000. PMID: 11034215.

Flores ER, Allen-Hoffmann BL, Lee D, Lambert PF. The human papillomavirus type 16 E7 oncogene is required for the productive stage of the viral life cycle. J Virol 74(14):6622-31, 7/2000. PMID: 10864676.

Flores ER, Lambert PF. Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle. J Virol 71(10):7167-79, 10/1997. PMID: 9311789.

Invited Articles

Su X, Chakravarti D, Flores ER. p63 steps into the limelight: crucial roles on the suppression of tumorigenesis and metastasis. Nat Rev Cancer. 2012 Dec 21;13(2):136-43. PMID: 23344544.

Flores ER, Lozano G. The p53 family grows old. Genes Development. 2012 Sep 15;26(18):1997-2000. PMID: 22987633.

Flores ER. p73 is critical for the persistence of memory. Cell Death & Differentiation 18(3):381-2, 3/2011. PMID: 21317911.

Flores ER, Halder G. Stem cell proliferation in the skin: alpha-catenin takes over the hippo pathway. Sci Signal 4(183):pe34, 2011. e-Pub 7/2011. PMID: 21791701.

Su X and Flores ER. TAp63: The Fountain of Youth. Impact Aging 1(10):866-869, 10/2009. e-Pub 10/2009. Full article.

Flores ER. The roles of p63 in cancer. Cell Cycle 6(3). e-Pub 2/2007. PMID: 17264676.

Iwakuma T, Lozano G, Flores ER. Li-Fraumeni syndrome: a p53 family affair. Cell Cycle 4(7):865-7, 7/2005. PMID: 15917654.

Book Chapters

Flores ER and Jacks T. p53 Family Members; p63 and p73. In: The p53 Tumor Suppressor Pathway and Cancer, 2005.


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