The Corse laboratory studies mechanisms that regulate T cell responsiveness and how these mechanisms contribute to chronic inflammation. Using novel mouse models of chronic liver disease, we investigate factors that contribute to disease pathogenesis, including autoreactive T cells and intestinal microbiota.
Chronic liver disease is the most common cause of hepatocellular carcinoma, and we are interested in how the inflammatory microenvironment in chronically diseased liver tissue influences the development of liver cancer. We use a variety of techniques to study T cell responses and development of chronic inflammation, including flow cytometry, histology, immunohistochemistry, in vitro assays of lymphocyte function, and molecular biology.
The Corse laboratory is part of the Department of Immunology and the Center for Cancer Immunology Research. Dr. Corse is an associate member of the Texas Medical Center Digestive Diseases Center. This site has sections devoted to current research, contact information, and recent publications.