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Current Research

Fusion protein ligand specific for the T cell costimulatory receptor CD28

We recently identified a novel, spontaneous mouse model of chronic liver inflammation. The mice express a ligand specific for the CD28 costimulatory receptor on T-lymphocytes, and develop chronic liver disease characterized by infiltration of CD8+ T-lymphocytes and deposition of collagen in the liver tissue (fibrosis).

We are investigating the potential autoimmune nature of the CD8+ T cell response, as well as examining other factors that may contribute to the development of chronic liver disease, such as intestinal microbiota. We are interested in the identification of pathways that are involved in the progression from chronic liver disease to liver cancer.

T cell proliferation assay using antigen-presenting cells bearing the CD28-specific ligand

T cell infiltration of liver tissue in mice expressing the CD28-specific ligand

© 2014 The University of Texas MD Anderson Cancer Center