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Publications

  1. Chen, T. and Dent, S.Y. (2014) Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat. Rev. Genet. 15, 93-106.
  2. Kim, S.J., Zhao, H., Hardikar, S., Singh, A.K., Goodell, M.A., and Chen, T. (2013) A DNMT3A muation common in AML exhibits dominant-negative effects in murine ES cells. Blood 122, 4086-4089.
  3. Zhao, H. and Chen, T. (2013) Tet family of 5-methylcytosine dioxygenases in mammalian development. J. Hum. Genet.58, 421-427.
  4. Nicholson, T.B., Singh, A.K., Su, H., Hevi, S., Wang, J., Bajko, J., Li, M., Valdez, R., Goetschkes, M., Capodieci, P., Loureiro, J., Cheng, X., Li, E., Kinzel, B., Labow, M., and Chen, T. (2013) A hypomorphic Lsd1 allele results in heart development defects in mice. PLoS One 8, e60913.
  5. Saferali, A., Moussette, S., Chan, D., Trasler, J., Chen, T., Rozen, R., and Naumova, A.K. (2012) DNA methyltransferase 1 (Dnmt1)mutation affects Snrpn imprinting in the mouse male germ line. Genome 55, 673-682.
  6. Stadtfeld, M., Apostolou, E., Ferrari, F., Choi, J., Walsh, R.M., Chen, T., Ooi, S., Kim, S.Y., Bestor, T.H., Shioda, T., Park, P.J., and Hochedlinger, K. (2012) Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat. Genet. 44, 398-405.
  7. Chen, T. (2011) Mechanistic and functional links between histone methylation and DNA methylation. Prog. Mol. Biol. Transl. Sci. 101, 335-348.
  8. Xu, Y., Wu, F., Tan, L., Kong, L., Xiong, L., Deng, J., Barbera, A.J., Zheng, L., Zhang, H., Huang, S., Min, J., Nicholson, T., Chen, T., Xu, G., Shi, Y., Zhang, K., Shi, Y.G. (2011) Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol. Cell 42, 451-464. 
  9. Nguyen, A.T., Neppl, R.L., Kallin, E.M., Chen, T., Wang, D.-Z., Zhang, Y. (2011) DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 25, 263-274.
  10. He, X.-J., Chen, T. and Zhu, J.-K. (2011) Regulation and function of DNA methylation in plants and animals. Cell Res. 21, 442-465.
  11. Cho, H.-S., Suzuki, T., Dohmae, N., Hayami, S., Unoki, M., Chen, T., Kurash, J., Field, H.I., Ponder, B.A.J., Nakamura, Y., Hamamoto, R. (2011) Demethylation of MYPT1 by LSD1 promotes cell cycle progression in cancer cells. Cancer Res. 71, 655-660.
  12. Singh, P., Han, L., Rivas, G.E., Lee, D.-H., Nicholson, T.B., Larson, G.P., Chen, T. and Szabo, P.E. (2010) Allele-specific H3K79 di- versus tri-methylation distinguishes opposite parental alleles at imprinted regions. Mol. Cell. Biol. 30, 2693-2707.
  13. Lohmann, F., Loureiro, J., Su, H., Fang, Q., Lei, H., Lewis, T., Yang, Y., Labow, M., Li, E., Chen, T. and Kadam, S. (2010) KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells 28, 201-212.
  14. Ciccone, D.N., Su, H., Hevi, S., Gay, F., Lei, H., Bajko, J., Xu, G., Li, E. and Chen, T. (2009) KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 461, 415-418.
  15. Yu, Z., Chen, T., Hebert, J., Li, E. and Richard, S. (2009) A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol. Cell. Biol. 29, 2982-2996.
  16. Wang, J., Hevi, S., Kurash, J.K., Lei, H., Gay, F., Bajko, J., Su, H., Sun, W., Chang, H., Xu, G., Gaudet, F., Li, E. and Chen, T. (2009) The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat. Genet. 41, 125-129.
  17. Ciccone, D.N. and Chen, T. (2009) Histone lysine methylation in genomic imprinting. Epigenetics 4, 216-220.
  18. Nicholson, T.B., Chen, T. and Richard, S. (2009) The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. Pharmacol. Res. 60, 466-474.
  19. Nicholson, T.B. and Chen, T. (2009) LSD1 demethylates histone and non-histone proteins. Epigenetics 4, 129-132.
  20. Jones, B., Su, H., Bhat, A., Lei, H., Bajko, J., Hevi, S., Baltus, G.A., Kadam, S., Zhai, H., Valdez, R., Gonzalo, S., Zhang, Y., Li, E. and Chen, T. (2008) The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet. 4, e1000190.
  21. Benetti, R., Gonzalo, S., Jaco, I., Muñoz, P., Gonzalez, S., Schoeftner, S., Murchison, E., Andl, T., Chen, T., Klatt, P., Li, E., Serrano, M., Millar, S., Hannon, G. and Blasco, MA. (2008) A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat. Struct. Mol. Biol. 15, 268-279.
  22. Hu, YG., Hirasawa, R., Hu, JL., Hata, K., Jin, Y., Chen, T., Li, E., Rigolet, M., Viegas-Pequignot, E., Sasaki, H. and Xu, GL. (2008) Regulation of DNA methylation activity through DNMT3L promoter methylation by DNMT3 enzymes in embryonic development. Hum. Mol. Genet. 17, 2654-2664.
  23. Schmid R.S., Tsujimoto, N., Qu, Q., Lei, H., Li, E., Chen, T. and Blaustein, C. (2008) A methyl-CpG-binding protein 2-enhanced green fluorescence protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome. Neuroreport 19, 393-398.
  24. Li, JY., Pu, MT., Hirasawa, R., Li, BZ., Huang, YN., Zeng, R., Jing, NH., Chen, T., Li, E., Sasaki, H. and Xu, GL. (2007) Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol. Cell. Biol. 27, 8748-8759.
  25. Chen, T., Hevi, S., Gay, F., Tsujimoto, N., He, T., Zhang, B., Ueda, Y. and Li, E. (2007) Complete inactivation of DNMT1 leads to mitotic catastrophe in h uman cancer cells. Nat. Genet. 39, 391-396.
  26. Zhu, H., Geiman, T. M., Xi, S., Jiang, Q., Schmidtmann, A., Chen, T., Li, E. and Muegge, K. (2006) Lsh is involved in de novo methylation of DNA. EMBO J. 25, 335-345.
  27. Chen, T. and Li, E. (2006) Establishment and maintenance of DNA methylation patterns in mammals. Curr. Top. Microbiol. Immunol. 301, 179-201.
  28. Gonzalo, S., Fraga, M. F., Chen, T., Li, E., Esteller, M. and Blasco, M. A (2006) DNA methyltransferases controls telomere length and telomere recombination in mammalian cells. Nat. Cell Biol. 8, 416-424.
  29. Ueda, Y., Okano, M., Williams, C., Chen, T., Georgopoulos, K. and Li, E. (2006) Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development 133, 1183-1192.
  30. Chen, T. and Li, E. (2005) DNA methylation regulates genomic imprinting, X inactivation, and gene expression during mammalian development. In: Gene Expression and Regulation (ed. J. Ma), a Current Scientific Frontiers Book, Higher Education Press & Springer, pp377-391.
  31. Dodge, J. E., Okano, M., Dick, F., Tsujimoto, N., Chen, T., Wang, S., Ueda, Y., Dyson, N. and Li, E. (2005) Inactivation of Dnmt3b in mouse embryonic fibroblasts results in hypomethylation, chromosomal instability, and spontaneous immortalization. J. Biol. Chem. 280, 17986-17991.
  32. Richard, S., Torabi, N., Franco, G. V., Tremblay, G. A., Chen, T., Vogel, G., Morel, M., Cleroux, P., Komarova, S., Tremblay, M. L., Li, W., Li, A., Gao, Y. J. and Henderson, J. E. (2005) Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet. 1(6), e74, 0676-0688.
  33. Chen, T., Tsujimoto, N. and Li, E. (2004) The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentromeric heterochromatin. Mol. Cell. Biol. 24, 9048-9058.
  34. Chen, T. and Li, E. (2004) Structure and function of eukaryotic DNA methyltransferases. Curr. Top. Dev. Biol. 60, 55-89.
  35. Fang, J., Chen, T., Chadwick, B., Li, E. and Zhang, Y. (2004) Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J. Biol. Chem. 279, 52812-52815.
  36. Chen, T., Ueda, Y., Dodge, J. E., Wang, Z. and Li, E. (2003) Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol. Cell. Biol. 23, 5594-5605.
  37. Lehnertz, B., Ueda, Y., Derijck, A. A. H. A., Braunschweig, U., Perez-Burgos, L., Kubicek, S., Chen, T., Li, E., Jenuwein, T. and Peters, A. H. F. M. (2003) Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr. Biol. 13, 1192-1200.
  38. Chen, T., Ueda, Y., Xie, S. and Li, E. (2002) A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J. Biol. Chem. 277, 38746-38754.
  39. Larocque, D., Pilotte, J., Chen, T., Cloutier, F., Massie, B., Pedraza, L., Couture, R., Lasko, P., Almazan, G. and Richard, S. (2002) Nuclear retention of MBP mRNAs in the quaking viable mice. Neuron 36, 815-829.
  40. Chen, T., Cote, J. and Richard, S. (2001) Identification of Sam68 arginine-rich sequences capable of conferring non-specific RNA binding to the GSG domain. J. Biol. Chem. 276, 30803-30811.
  41. Derry, J. J., Richard, S., Carvajal, H. V., Ye, X ., Vasioukhin, V., Cochrane, A. W., Chen, T. and Tyner, A. (2000) Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. Mol. Cell. Biol. 20, 6114-6126.
  42. Chen, T., Boisvert, F.-M., Bazett-Jones, D. P. and Richard, S. (1999) A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cells. Mol. Biol. Cell 10, 3015-3033.
  43. Di Fruscio, M., Chen, T. and Richard, S. (1999) Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. Proc. Natl. Acad. Sci. USA 96, 2710-2715. (Di Fruscio and Chen contributed equally to this work).
  44. Aarts, M. M., Levy, D., He, B., Stregger, S., Chen, T., Richard, S. and Henderson, J. E. (1999) Parathyroid hormone-related protein interacts with RNA. J. Biol. Chem. 274, 4832-4838.
  45. Chen, T. and Richard, S. (1998) Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization. Mol. Cell. Biol. 18, 4863-4871.
  46. Di Fruscio, M., Chen, T., Bonyadi, S., Lasko, P. and Richard, S. (1998) The identification of two Drosophila K homology domain proteins: KEP1 and SAM are members of the Sam68 family of GSG domain proteins. J. Biol. Chem. 273, 30122-30130.
  47. Chen, T., Damaj, B., Herriera, C. Lasko, P. and Richard, S. (1997) Self-association of the single KH domain family members Sam68, GRP-33, GLD-1 and Qk1: role of the KH domain. Mol. Cell. Biol. 17, 5707-5718.
  48. Rael, E. D., Rivas, J. Z., Chen, T., Maddux, N., Huizar, E. and Lieb, C. S. (1997) Differences in fibrinolysis and complement inactivation by venom from different northern blacktailed rattlesnakes (Crotalus molossus molossus). Toxicon  35, 505-513.
  49. Chen, T. and Rael, E. D. (1997) Purificationof M5, a fibrinolytic proteinase from Crotalus molossus molossus venom that attacks complement. Int. J. Biochem. Cell Biol. 29, 789-799.

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