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Publications

Notable Publications

Almeida MI, Nicoloso MS, Zeng L, Ivan C, Spizzo R, Gafà R, Xiao L, Zhang X, Vannini I, Fanini F, Fabbri M, Lanza G, Reis RM, Zweidler-McKay PA, Calin GA. Strand-specific miR-28-5p and miR-28-3p have distinct effects in colorectal cancer cells. 
Gastroenterology. 2012 Apr;142(4):886-896.e9. doi: 10.1053/j.gastro.2011.12.047. Epub 2012 Jan 10. PubMed PMID: 22240480; PubMed Central PMCID: PMC3321100.
The identification of antagonistic effects of the two miRNAs expressed from the same hairpin structure.

Fabbri M, Bottoni A, Shimizu M, Spizzo R, Nicoloso MS, Rossi S, Barbarotto E, Cimmino A, Adair B, Wojcik SE, Valeri N, Calore F, Sampath D, Fanini F, Vannini I, Musuraca G, Dell'Aquila M, Alder H, Davuluri RV, Rassenti LZ, Negrini M, Nakamura T, Amadori D, Kay NE, Rai KR, Keating MJ, Kipps TJ, Calin GA, Croce CM. Association of a microRNA/TP53 feedback circuitry with pathogenesis and outcome of B-cell chronic lymphocytic leukemia. 
JAMA. 2011 Jan 5;305(1):59-67. doi: 10.1001/jama.2010.1919. PubMed PMID: 21205967; PubMed Central PMCID: PMC3690301.
The identification of a complex network of miRNAs and coding genes influencing the natural history of the most frequent type of leukemia in the western World.

Rossi S, Shimizu M, Barbarotto E, Nicoloso MS, Dimitri F, Sampath D, Fabbri M, Lerner S, Barron LL, Rassenti LZ, Jiang L, Xiao L, Hu J, Secchiero P, Zauli G, Volinia S, Negrini M, Wierda W, Kipps TJ, Plunkett W, Coombes KR, Abruzzo LV, Keating MJ, Calin GA. microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. 
Blood. 2010 Aug 12;116(6):945-52. doi: 10.1182/blood-2010-01-263889. Epub 2010 Apr 14. PubMed PMID: 20393129.
The identification of an miR-21 score that classifies better than any currently used biomarkers CLL patients with good prognosis versus patients with bad prognosis.

Nicoloso MS, Sun H, Spizzo R, Kim H, Wickramasinghe P, Shimizu M, Wojcik SE, Ferdin J, Kunej T, Xiao L, Manoukian S, Secreto G, Ravagnani F, Wang X, Radice P, Croce CM, Davuluri RV, Calin GA. Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. 
Cancer Res. 2010 Apr 1;70(7):2789-98. doi: 10.1158/0008-5472.CAN-09-3541. Epub 2010 Mar 23. PubMed PMID: 20332227; PubMed Central PMCID: PMC2853025.
Identification of a new mechanism of cancer predisposition in familial breast cancer patients by SNP located in the microRNA interactor sites of breast cancer predisposing genes.

Eiring AM, Harb JG, Neviani P, Garton C, Oaks JJ, Spizzo R, Liu S, Schwind S, Santhanam R, Hickey CJ, Becker H, Chandler JC, Andino R, Cortes J, Hokland P, Huettner CS, Bhatia R, Roy DC, Liebhaber SA, Caligiuri MA, Marcucci G, Garzon R, Croce CM, Calin GA, Perrotti D. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. 
Cell. 2010 Mar 5;140(5):652-65. doi: 10.1016/j.cell.2010.01.007. PubMed PMID: 20211135; PubMed Central PMCID: PMC2924756.
Identification of a new mechanism of action of microRNAs by directly interacting with proteins from the hRNP family.

Spizzo R, Nicoloso MS, Croce CM, Calin GA. SnapShot: MicroRNAs in Cancer.
Cell. 2009 May 1;137(3):586-586.e1. doi: 10.1016/j.cell.2009.04.040. PubMed PMID: 19410551. 

An up-to-date view of the microRNA roles in cancer as suppressors and oncogenes.

Nicoloso MS, Spizzo R, Shimizu M, Rossi S, Calin GA. MicroRNAs--the micro steering wheel of tumour metastases.
Nat Rev Cancer. 2009 Apr;9(4):293-302. doi: 10.1038/nrc2619. Epub 2009 Mar 5. PubMed PMID: 19262572. 
An up-to-date view of the microRNA role in metastases as suppressors or activators. We propose the hypothesis that the same miRNAs are involved in stemness and dissemination.

Calin GA, Cimmino A, Fabbri M, Ferracin M, Wojcik SE, Shimizu M, Taccioli C, Zanesi N, Garzon R, Aqeilan RI, Alder H, Volinia S, Rassenti L, Liu X, Liu CG, Kipps TJ, Negrini M, Croce CM. MiR-15a and miR-16-1 cluster functions in human leukemia.
Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5166-71. doi: 10.1073/pnas.0800121105. Epub 2008 Mar 24. PubMed PMID: 18362358; PubMed Central PMCID: PMC2278188.
The identification of specific targets that could explain why the cluster miR-15a/16 causes CLL when deleted in human B cells.

Calin GA, Liu CG, Ferracin M, Hyslop T, Spizzo R, Sevignani C, Fabbri M, Cimmino A, Lee EJ, Wojcik SE, Shimizu M, Tili E, Rossi S, Taccioli C, Pichiorri F, Liu X, Zupo S, Herlea V, Gramantieri L, Lanza G, Alder H, Rassenti L, Volinia S, Schmittgen TD, Kipps TJ, Negrini M, Croce CM. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas.
Cancer Cell. 2007 Sep;12(3):215-29. PubMed PMID: 17785203.
The identification of a new family of non-codingRNAs involved in cancers -- the ultraconserved genes.

Calin GA, Croce CM. MicroRNA signatures in human cancers.
Nat Rev Cancer. 2006 Nov;6(11):857-66. Review. PubMed PMID: 17060945.
We present the main principles of miRNA profiling and the significant paradigms useful for patient diagnosis and therapy.

Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, Visone R, Iorio M, Roldo C, Ferracin M, Prueitt RL, Yanaihara N, Lanza G, Scarpa A, Vecchione A, Negrini M, Harris CC, Croce CM. A microRNA expression signature of human solid tumors defines cancer gene targets.
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2257-61. Epub 2006 Feb 3. PubMed PMID: 16461460; PubMed Central PMCID: PMC1413718.
A signature of miRNAs common for six types of solid cancers obtained by a very extensive analysis of human tumors.

Calin GA, Ferracin M, Cimmino A, Di Leva G, Shimizu M, Wojcik SE, Iorio MV, Visone R, Sever NI, Fabbri M, Iuliano R, Palumbo T, Pichiorri F, Roldo C, Garzon R, Sevignani C, Rassenti L, Alder H, Volinia S, Liu CG, Kipps TJ, Negrini M, Croce CM. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia.
N Engl J Med. 2005 Oct 27;353(17):1793-801. Erratum in: N Engl J Med. 2006 Aug 3;355(5):533. PubMed PMID: 16251535.
The first description of germline mutations located in the cluster miR-15a/16 in human cancers, including familial cases with CLL and breast cancers.

Calin GA, Trapasso F, Shimizu M, Dumitru CD, Yendamuri S, Godwin AK, Ferracin M, Bernardi G, Chatterjee D, Baldassarre G, Rattan S, Alder H, Mabuchi H, Shiraishi T, Hansen LL, Overgaard J, Herlea V, Mauro FR, Dighiero G, Movsas B, Rassenti L, Kipps T, Baffa R, Fusco A, Mori M, Russo G, Liu CG, Neuberg D, Bullrich F, Negrini M, Croce CM. Familial cancer associated with a polymorphism in ARLTS1.
N Engl J Med. 2005 Apr 21;352(16):1667-76. PubMed PMID: 15843669.
The identification of a truncation mutation in a Ras family gene that is involved in familial cancers.

Calin GA, Dumitru CD, Shimizu M, Bichi R, Zupo S, Noch E, Aldler H, Rattan S, Keating M, Rai K, Rassenti L, Kipps T, Negrini M, Bullrich F, Croce CM. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia.
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9. Epub 2002 Nov 14. PubMed PMID: 12434020; PubMed Central PMCID: PMC137750.
Founding publication in the field of microRNAs and their involvement in cancer. We identified that deletions of two microRNAs, miR-15a and 16 that are located on a cluster of chromosome 13, are very frequent in CLL.

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