Publications
2013
Kurinna S, Stratton SA, Coban Z, Schumacher JM, Grompe M, Duncan AW, Barton MC. p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology 2013 Jan 8. doi: 10.1002/hep.26233. [Epub ahead of print] PMID: 23300120.
2012
Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, et al. (2012) Genome-Wide Location Analysis Reveals Distinct Transcriptional Circuitry by Paralogous Regulators Foxa1 and Foxa2. PLoS Genet 8(6): e1002770. PMID: 22737085.
Stratton SA, Barton MC. p53-Mediated regulation of hepatic lipid metabolism: forging links between metabolism, atherogenesis, and cancer. J Hepatol. 2012 Mar; 56(3):518-9. Epub 2011 Oct 31. PMID: 22051552.
Coban Z, Barton MC. Integrative genomics: Liver regeneration and hepatocellular carcinoma. J Cell Biochem. 2012 Feb 17. doi:10.1002/jcb.24104. PMID: 22345090.
Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, Zwaka TP, Kyba M, Barton MC. p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol. 2012 Feb;10(2):e1001268. Epub 2012 Feb 28. PMID: 22389628.
2011
Singh MM, Manton CA, Bhat KP, Tsai WW, Aldape K, Barton MC, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol 2011 Aug;13(8):894-903. Epub 2011 Jun 8. PMID: 21653597.
Wilson MA, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton MC, Dent SY. Ubp8 and SAGA Regulate Snf1 AMP Kinase Activity. Cell Biol 2011 Aug;31(15):3126-35. Epub 2011 May 31. PMID: 21628526.
Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol 2011 Jan 1;349(1):90-9. Epub 2010 Oct 20. PMID: 20969844.
2010
Tsai W-W, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai C-Y, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung M-C, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature 2010 Dec 16; 468:927-932. PMID: 21164480.
Kurinna S, Barton MC. Hierarchies of transcriptional regulation during liver regeneration. Prog Mol Biol Transl Sci 2010;97:201-27. Review. PMID: 21074734.
Jain AK, Barton MC. Making sense of ubiquitin ligases that regulate p53. Cancer Biol Ther 2010 Oct;10(7):665-72. Epub 2010 Oct 1. Review. PMID: 20930521.
Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC. Direct activation of forkhead box O3 by tumor suppressor p53 and p73 is disrupted during liver regeneration in mice. Hepatology 2010 Sep; 52(3):1023-32. PMID: 20564353.
Dejosez M, Levine SS, Frampton GM, Whyte WA, Stratton SA, Barton MC, Gunaratne PH, Young RA, Zwaka TP. Ronin/Hcf-1 binds to a hyper-conserved enhancer element and regulates genes involved in the growth of embryonic stem cells. Genes Dev 2010 Jul 15;24(14):1479-84. Epub 2010 Jun 25. PMID: 20581084.
Taube JH, Allton K, Duncan SA, Shen L, Barton MC. Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells. J Biol Chem. 2010 May 21;285(21):16135-44. Epub 2010 Mar 26. PMID: 20348100.
Kurinna S, Barton MC. Cascades of transcription regulation during liver regeneration. Int J Biochem Cell Biol. 2010 Mar 20. [Epub ahead of print.] PMID: 20307684.
2009
Jain AK, Barton MC. Regulation of p53: TRIM24 enters the RING. Cell Cycle. 2009 Nov 15;8(22):3668-74. Epub 2009 Nov 2. Review. PMID: 19844164.
Minard ME, Jain AK, Barton MC. Analysis of epigenetic alterations to chromatin during development. Genesis. 2009 Aug;47(8):559-72. Review. PMID: 19603511.
Allton K, Jain A, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton M. Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A 106(28):11612-6, 7/14/2009. e-Pub 6/25/2009. PMCID: PMC2710642.
2008
Wilkinson DS, Tsai WW, Schumacher MA, Barton MC. Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer TGF-mediated transcription repression. Mol Cell Biol 28:1988-1998, 2008. PMID: 18212064.
Johnson AB, Denko N, Barton MC. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutation Res 640:174-179, 2008. PMID: 18294659.
Tsai WW, Nguyen TT, Shi Y, Barton MC. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol 28(17):5139-5146, 2008. e-Pub 6/23/2008. PMCID: PMC2519740.
Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ.. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A 105(31):10859-10864, 2008. e-Pub 7/31/2008. PMCID: PMC2504784.
Cirillo LA, Barton MC. Many Forkheads in the road to regulation. EMBO Rep 9:721-724, 2008. PMID: 18617889.
2007
Qian J, Steigerwald K, Combs KA, Barton MC, Groden J. Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of of APC in apoptosis. Oncogene 26:4872-4876, 2007. PMID: 17297457.
Chen L, Firozi P, Barton M, Templeton NS. Widespread, exceptionally high levels of histone H3 lysine-4 tri-methylation largely mediate "privileged" gene expression. Gene Expression 13:271-282, 2007. PMID: 17605300.
Johnson AB and Barton MC. Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res 618(1-2):149-162, 2007. e-Pub 1/21/2007. PMCID: PMC1924842.
2006
Barton MC, Akli S, Keyomarsi K. Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer. J Cell Physiol 209(3):686-694, 12/2006. PMID: 17001684.
Barton MC. Influences along the path to maturity: regulation of cellular levels of RNA. Biochim Biophys Acta 1759(8-9):385-387, Aug-Sep, 8/2006. e-Pub 9/5/2006. PMID: 17007943.
2005
Cui R, Nguyen TT, Taube JH, Stratton SA, Feuerman MH, Barton MC. Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem 280(47):39152-60, 11/2005. e-Pub 10/2/2005. PMID: 16203738.
Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD. Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell 8(6):843-54, 6/2005. PMID: 15935774.
Nguyen TT, Cho K, Stratton SA, Barton MC. Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene. Mol Cell Biol 25(6):2147-57, 3/2005. PMCID: PMC1061614.
Wilkinson DS, Ogden SK, Stratton SA, Piechan JL, Nguyen TT, Smulian GA, Barton MC. A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol 25(3):1200-12, 2/2005. PMCID: PMC544019.
Steigerwald K, Behbehani GK, Combs KA, Barton MC, Groden J. The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Mol Cancer Res 3(2):78-89, 2/2005. PMID: 15755874.
2000-2004
Denko N, Wernke-Dollries K, Johnson AB, Hammond E, Chiang CM, Barton MC. Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem 278:5744-9, 2/2003. PMID: 12477712.
Ogden SK, Lee KC, Wernke-Dollries K, Stratton SA, Aronow B, Barton MC. p53 targets chromatin structure alteration to repress alpha-fetoprotein gene expression. J Biol Chem 276:42057-62, 11/2001. PMID: 11572852.
Ogden SK, Lee KC, Barton MC. Hepatitis B viral transactivator HBx alleviates p53-mediated repression of alpha-fetoprotein gene expression. J Biol Chem 275:27806-14, 9/2000. PMID: 10842185.
Rockx DA, Mason R, van Hoffen A, Barton MC, Citterio E, Bregman DB, van Zeeland AA, Vrieling H, Mullenders LH. UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II. Proc Natl Acad Sci U S A 97:10503-8, 9/2000. PMID: 10973477.
Crowe AJ, Piechan JL, Sang L, Barton MC. S-Phase progression mediates activation of a silenced gene in synthetic nuclei. Mol Cell Biol 20:4169-80, 6/2000. PMID: 10805758.