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Current Research

Oct4 expression in mES cells by immunofluorescence

Oct4 expression in mES cells by immunofluorescence

Our laboratory is focused on basic mechanisms of regulated and aberrant gene expression during differentiation, tissue regeneration and cancer, especially as dictated by members of the p53- family, their interacting protein partners, and chromatin structure. We are using deep sequencing, proteomic analyses and bioinformatics to determine chromatin interactions, post-translational modifications and protein partners of p53. Our model systems of interest are embryonic stem cells, liver regeneration and breast cancer. A major focus is TRIM24, a previously unknown E3-ubiquitin ligase of p53 that we identified. TRIM24 co-activates estrogen receptor and is a histone reader of a unique signature present at estrogen-regulated genes in breast cancer cells. Additionally, we are currently defining the impact of TRIM24, and other p53 regulatory proteins, on p53-functions in embryonic stem cells, and how p53-mediated regulation is temporally controlled during liver regeneration.

Cascades of transcription regulation during liver regeneration

Cascades of transcription regulation during liver regeneration


© 2014 The University of Texas MD Anderson Cancer Center