Publications
Selected Publications (1999 - 2009)
Trepel M, Stoneham CA, Eleftherohorinou H, Mazarakis ND, Pasqualini R, Arap W, Hajitou A. A herotypic bystander effect for tumor cell killing after adeno-associated virus/phage-mediated, vascular-targeted suicide gene transfer. Mol Cancer Ther. 2009; 8:2383-91. Abstract, PDF
Souza GR, Staquicini FI, Christianson DR, Ozawa MG, Miller JH, Pasqualini R, Arap W. Combinatorial targeting and nanotechnology applications. Biomed Microdevices. 2009. Abstract, PDF
Stefanidakis M, Karjalainen K, Jaalouk DE, Gahmberg CG, O'Brien S, Pasqualini R, Arap W, Koivunen E. Role of leukemia cell invadosome in extramedullary infiltration. Blood. 2009. Abstract, PDF
Jonasch E, Wood CG, Matin SF, Tu SM, Pagliaro LC, Corn PG, Aparicio A, Tamboli P, Millikan RE, Wang X, Araujo JC, Arap W, Tannir N. Phase II presurgical feasibility study of bevacizumab in untreated patients with metastatic renal cell carcinoma. J Clin Oncol. 2009. Abstract, PDF
Zhang Y, Daquinag A, Traktuev DO, Amaya-Manzanares F, Simmons PJ, March KL, Pasqualini R, Arap W, Kolonin MG. White adipose tissue cells are recruited by experimental tumors and promote cancer progression in mouse models. Cancer Res. 2009; 69:5259-66. Abstract, PDF
Moeller BJ, Pasqualini R, Arap W. Targeting cancer-specific synthetic lethality in double-strand DNA break repair. Cell Cycle. 2009; 8:1872-6. Abstract, PDF
Paoloni MC, Tandle A, Mazcko C, Hanna E, Kachala S, Leblanc A, Newman S, Vail D, Henry C, Thamm D, Sorenmo K, Hajitou A, Pasqualini R, Arap W, Khanna C, Libutti SK. Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature. PLoS ONE. 2009; 4:e4972. Abstract, PDF
Lewis VO, Ozawa MG, Deavers MT, Wang G, Shintani T, Arap W, Pasqualini R. The interleukin-11 receptor alpha as a candidate ligand-directed target in osteosarcoma: consistent data from cell lines, orthotopic models, and human tumor samples. Cancer Res. 2009; 69:1995-9. Abstract, PDF
Marchiò S, Arap W, Pasqualini R. Targeting the extracellular signature of metastatic colorectal cancers. Expert Opin Ther Targets. 2009; 13:363-79. Abstract, PDF
Mandelin J, Lin EC, Hu DD, Knowles SK, Do KA, Wang X, Sage EH, Smith JW, Arap W, Pasqualini R. Extracellular and intracellular mechanisms that mediate the metastatic activity of exogenous osteopontin. Cancer. 2009; 115:1753-64. Abstract, PDF
Staquicini FI, Dias-Neto E, Li J, Snyder EY, Sidman RL, Pasqualini R, Arap W. Discovery of a functional protein complex of netrin-4, laminin gamma1 chain, and integrin alpha6beta1 in mouse neural stem cells. Proc Natl Acad Sci U S A. 2009; 106:2903-8. Abstract, PDF
Mintz PJ, Cardó-Vila M, Ozawa MG, Hajitou A, Rangel R, Guzman-Rojas L, Christianson DR, Arap MA, Giordano RJ, Souza GR, Easley J, Salameh A, Oliviero S, Brentani RR, Koivunen E, Arap W, Pasqualini R. An unrecognized extracellular function for an intracellular adapter protein released from the cytoplasm into the tumor microenvironment. Proc Natl Acad Sci U S A. 2009; 106:2182-7. Abstract, PDF
Moeller BJ, Pasqualini R, Arap W. Ceramide-mediated apoptosis following ionizing radiation in human prostate cancer cells: PKCalpha joins the fray. Cancer Biol Ther. 2009; 8:64-5. Abstract, PDF
Tandle A, Hanna E, Lorang D, Hajitou A, Moya CA, Pasqualini R, Arap W, Adem A, Starker E, Hewitt S, Libutti SK. Tumor vasculature-targeted delivery of tumor necrosis factor-alpha. Cancer. 2009; 115:128-39. Abstract, PDF
Tagore DM, Nolte WM, Neveu JM, Rangel R, Guzman-Rojas L, Pasqualini R, Arap W, Lane WS, Saghatelian A. Peptidase substrates via global peptide profiling. Nat Chem Biol. 2009; 5:23-5. Comment
Decuzzi P, Pasqualini R, Arap W, Ferrari M. Intravascular delivery of particulate systems: does geometry really matter? Pharm Res. 2009; 26:235-43. Abstract, PDF
Cardó-Vila M, Zurita AJ, Giordano RJ, Sun J, Rangel R, Guzman-Rojas L, Anobom CD, Valente AP, Almeida FCL, Lahdenranta J, Kolonin MG, Arap W, Pasqualini R. A ligand peptide motif selected from a cancer patient is a receptor-interacting site within human interleukin-11. PLoS ONE. 2008; 3:e3452. Abstract, PDF
Giordano RJ, Lahdenranta J, Zhen LJ, Chukwueke U, Petrache I, Langley RR, Fidler IJ, Pasqualini R, Tuder RM, Arap W. Targeted induction of lung endothelial cell apoptosis causes emphysema-like changes in the mouse. J Biol Chem. 2008; 283:29447-29460. Abstract, PDF
Staquicini FI, Tandle A, Libutti SK, Sun J, Zigler M, Bar-Eli M, Aliperti F, Perez, EC, Gershenwald JE, Mariano M, Pasqualini R, Arap W, Lopes JD. A subset of host b-lymphocytes control melanoma metastasis through a MCAM/MUC18-dependent interaction: evidence from mice and humans. Cancer Res. 2008; 68:8419-8428. Abstract, PDF
Nie J, Chang B, Traktuev D, Sun J, March KL, Chan L, Sage EH, Pasqualini R, Arap W, Kolonin MG. Combinatorial Peptides Identify {alpha}5{beta}1 Integrin as a Receptor for the Matricellular Protein SPARC on Adipose Stromal Cells. Stem Cells. 2008. Abstract, PDF
Corti A, Curnis F, Arap W, Pasqualini R. The neovasculature-homing motif NGR: more than meets the eye. Blood. 2008. Abstract, PDF
Lin SH, Cheng CJ, Lee YC, Ye X, Tsai WW, Kim J, Pasqualini R, Arap W, Navone NM, Tu SM, Hu M, Yu-Lee LY Logothetis CJ. A 45-kDa ErbB3 secreted by prostate cancer cells promotes bone formation. Oncogene. 2008. Abstract, PDF
Ozawa MG, Zurita AJ, Dias-Neto E, Nunes DN, Sidman RL, Gelovani JG, Arap W, Pasqualini R. Beyond Receptor Expression Levels: The Relevance of Target Accessibility in Ligand-directed Pharmacodelivery Systems. Trends Cardiovasc Med. 2008; 18:126-132. Abstract, PDF
Souza GR, Yonel-Gumruk E, Fan D, Easley J, Rangel R, Guzman-Rojas L, Miller JH, Arap W, Pasqualini R. Bottom-up assembly of hydrogels from bacteriophage and Au nanoparticles: the effect of cis- and trans-acting factors. PLoS ONE. 2008; 21:2242. Abstract, PDF
Nishimura S, Takahashi S, Kamikatahira H, Kuroki Y, Jaalouk DE, O'Brien S, Koivunen E, Arap W, Pasqualini R, Nakayama H, Kuniyasu A. Combinatorial targeting of the macropinocytotic pathway in leukemia and lymphoma cells. J Biol Chem. 2008; 283:11752-11762. Abstract, PDF
Hajitou A, Lev DC, Hannay JA, Korchin B, Staquicini FI, Soghomonyan S, Alauddin MM, Benjamin RS, Pollock RE, Gelovani JG, Pasqualini R, Arap W. A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging. Proc Natl Acad Sci USA. 2008. Abstract, PDF
Wood KC, Azarin SM, Arap W, Pasqualini R, Langer R, Hammond PT. Tumor-Targeted Gene Delivery Using Molecularly Engineered Hybrid Polymers Functionalized with a Tumor-Homing Peptide. Bioconjug Chem. 2008. Abstract, PDF
Sato M, Arap W, Pasqualini R. Molecular targets on blood vessels for cancer therapies in clinical trials. Oncology. 2007. Abstract, PDF
Jaalouk DE, Ozawa MG, Sun J, Lahdenranta J, Schlingemann RO, Pasqualini R, Arap W. The Original Pathologische Anatomie Leiden-Endothelium Monoclonal Antibody Recognizes a Vascular Endothelial Growth Factor-Binding Site within Neuropilin-1. Cancer Res. 2007. Abstract, PDF, Supplementary Data
Lahdenranta J, Sidman RL, Pasqualini R, Arap W. Treatment of hypoxia-induced retinopathy with targeted proapoptotic peptidomimetic in a mouse model of disease. FASEB J. 2007. Abstract, PDF
Bover LC, Cardó-Vila M, Kuniyasu A, Sun J, Rangel R, Takeya M, Aggarwal BB, Arap W, Pasqualini R. A previously unrecognized protein-protein interaction between TWEAK and CD163: potential biological implications. J Immunol. 2007; 178:8183-8194. Abstract, PDF
Hajitou A, Rangel R, Trepel M, Soghomonyan S, Gelovani JG, Alauddin MM, Pasqualini R, Arap W. Design and construction of targeted AAVP vectors for mammalian cell transduction. Nat Protoc. 2007; 3: 523-531. Abstract, PDF
Soghomonyan S, Hajitou A, Rangel R, Trepel M, Pasqualini R, Arap W, Gelovani JG, Alauddin MM. Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU. Nat Protoc. 2007; 2: 416-423. Abstract, PDF
Rangel R, Sun Y, Guzman-Rojas L, Ozawa MG, Sun J, Giordano RJ, Van Pelt CS, Tinkey PT, Behringer RR, Sidman RL, Arap W, Pasqualini R. Impaired angiogenesis in aminopeptidase N-null mice. Proc Natl Acad Sci U S A. 2007; 14: 4588-4593. Abstract, PDF
Trepel M, Arap W, Pasqualini R. Selection, isolation, and identification of targeting peptides for ligand-directed gene delivery. In: Gene Transfer: A Laboratory Manual, New York: Cold Spring Harbor Laboratory Press. 2007; Ch. 30: 359-369. PDF
Ji Y, Yin GS, Tsui KW, Kolonin MG, Sun J, Arap W, Pasqualini R, Do KA. Bayesian mixture models for complex high dimensional count data in phage display experiments. Appl Statist. 2007; 56: 1-14. PDF
Kzhyshkowska J, Workman G, Cardó-Vila M, Arap W, Pasqualini R, Gratchev A, Krusell L, Goerdt S, Sage EH. Novel function of alternatively activated macrophages: stabilin-1 mediated clearance of SPARC. J Immunol. 2006; 176: 5825-5832. Abstract, PDF
Christianson DR, Ozawa MG, Arap W, Pasqualini R. Techniques to decipher molecular diversity by phage display. Methods Mol Biol. 2006; 357: 385-406. Abstract, PDF
Tuder RM, Yoshida T, Arap W, Pasqualini R, Petrache I. State of the Art. Cellular and Molecular Mechanisms of Alveolar Destruction in Emphysema: An Evolutionary Perspective. Proc Am Thorac Soc. 2006; 3: 503-510. Abstract, PDF
Souza GR, Levin CS, Hajitou A, Pasqualini R, Arap W, Miller JH. In vivo detection of gold-imidazole self-assembly complexes: NIR-SERS signal reporters. Anal Chem. 2006; 78: 6232-6237. Abstract, PDF
Kolonin MG, Sun J, Do KA, Vidal CI, Ji Y, Baggerly KA, Pasqualini R, Arap W. Synchronous selection of homing peptides for multiple tissues by in vivo phage display. FASEB J. 2006; 20: 979-981. Abstract, PDF,
Hajitou A, Trepel M, Lilley CE, Soghomonyan S, Alauddin MM, Marini FC 3rd, Restel BH, Ozawa MG, Moya CA, Rangel R, Sun Y, Zaoui K, Schmidt M, von Kalle C, Weitzman MD, Gelovani JG, Pasqualini R, Arap W. A hybrid vector for ligand-directed tumor targeting and molecular imaging. Cell. 2006; 125: 385-398. Abstract, PDF, Nature Reviews, PDF
Yao VJ, Ozawa MG, Varner AS, Kasman IM, Chanthery Y, Pasqualini R, Arap W, McDonald DM. Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels. Cancer Res. 2006; 66: 2639-2649. Abstract, PDF
Souza GR, Christianson DR, Staquicini FI, Ozawa MG, Snyder EY, Sidman RL, Miller JH, Arap W, Pasqualini R. Networks of gold nanoparticles and bacteriophage as biological sensors and cell-targeting agents. Proc Natl Acad Sci USA. 2006; 103: 1215-1220. Abstract, PDF
Kolonin MG, Bover L, Sun J, Zurita AJ, Do KA, Lahdenranta J, Cardó-Vila M, Giordano RJ, Jaalouk DE, Ozawa MG, Moya CA, Souza GR, Staquicini FI, Kunyiasu A, Scudiero DA, Holbeck SL, Sausville EA, Arap W, Pasqualini R. Ligand-directed surface profiling of human cancer cells with combinatorial peptide libraries. Cancer Res. 2006; 66: 34-40. Abstract, PDF
Giordano RJ, Anobom CD, Cardó-Vila M, Kalil J, Valente AP, Pasqualini R, Almeida FL, Arap W. Structural basis for the interaction of a vascular endothelial growth factor mimic peptide motif and its corresponding receptors. Chem Biol. 2005; 12: 1075-1083. Abstract, PDF
Pentz RD, Cohen CB, Wicclair M, DeVita MA, Flamm AL, Youngner SJ, Hamric AB, McCabe MS, Glover J, Kittiko WJ, Kinlaw K, Keller J, Asch A, Kavanagh JJ, Arap W. Ethics guidelines for research with the recently dead. Nat Med. 2005; 11: 1145-1149. Abstract, PDF
Lionakis MS, Lahdenranta J, Sun J, Liu W, Lewis RE, Albert ND, Pasqualini R, Arap W, Kontoyiannis DP. Development of a ligand-directed approach to study the pathogenesis of invasive aspergillosis. Infect Immun. 2005; 73: 7747-7758. Abstract, PDF
Ozawa MG, Yao VJ, Chanthery YH, Troncoso P, Uemura A, Varner AS, Kasman IM, Pasqualini R, Arap W, McDonald DM. Angiogenesis with pericyte abnormalities in a transgenic model of prostate cancer. Cancer. 2005; 104: 2104-2115. Abstract, PDF
Oh Y, Mohiuddin I, Sun C, Putman JB, Hong WK, Arap W, Pasqualini R. Phenotypic diversity of the lung vasculature in an experimental model of malignant melanoma metastases. Chest. 2005; 128: 596S-600S. Abstract, PDF
Barker TH, Baneyx G, Cardó-Vila M, Workman GA, Weaver M, Menon PM, Dedhar S, Rempel SA, Arap W, Pasqualini R, Vogel V, Sage EH. SPARC regulates extracellular matrix organization through its modulation of integrin-linked kinase activity. J Biol Chem. 2005; 280: 36483-36493. Abstract, PDF
Yao VJ, Ozawa MG, Trepel M, Arap W, McDonald DM, Pasqualini R. Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection. Am J Pathol. 2005; 166: 625-636. Abstract, PDF
Marchiò S, Alfano M, Primo L, Gramaglia D, Butini L, Gennero L, De Vivo E, Arap W, Giacca M, Pasqualini R, Bussolino F. Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein. Blood. 2005; 105: 2802-2811. Abstract, PDF
Zurita AJ, Troncoso P, Cardó-Vila M, Logothetis CJ, Pasqualini R, Arap W. Combinatorial screenings in patients: the interleukin-11 receptor alpha as a candidate target in the progression of human prostate cancer. Cancer Res. 2004; 64: 435-439. Cover, Abstract, PDF
Vidal CI, Mintz PJ, Lu K, Ellis LM, Manenti L, Giavazzi R, Gershenson DM, Broaddus R, Liu J, Arap W, Pasqualini R. An HSP90-mimic peptide revealed by fingerprinting the pool of antibodies from ovarian cancer patients. Oncogene. 2004; 23: 8859-8867. Abstract, PDF
Pasqualini R, Arap W. Hybridoma-free generation of monoclonal antibodies. Proc Natl Acad Sci U S A. 2004; 101: 257-259. Abstract, PDF
Marchiò S, Lahdenranta J, Schlingemann RO, Valdembri D, Wesseling P, Arap MA, Hajitou A, Ozawa MG, Trepel M, Giordano RJ, Nanus DM, Dijkman HB, Oosterwijk E, Sidman RL, Cooper MD, Bussolino F, Pasqualini R, Arap W. Aminopeptidase A is a functional target in angiogenic blood vessels. Cancer Cell. 2004; 5: 151-162. Abstract, PDF
Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004; 10: 625-632. Abstract, PDF, Chem & Eng News, Nature News & Views
Chen L, Zurita AJ, Ardelt PU, Giordano RJ, Arap W, Pasqualini R. Design and validation of a bifunctional ligand display system for receptor targeting. Chem Biol. 2004; 11: 1081-1091. Abstract, PDF
Arap MA, Lahdenranta J, Hajitou A, Marini FC 3rd, Wood CG, Wright KC, Fueyo J, Arap W, Pasqualini R. Model of unidirectional transluminal gene transfer. Mol Ther. 2004; 9: 305-310. Abstract, PDF
Arap W, Pasqualini R. Engineered embryonic endothelial progenitor cells as therapeutic Trojan horses. Cancer Cell. 2004; 5: 406-408. Abstract, PDF
Arap MA, Lahdenranta J, Mintz PJ, Hajitou A, Sarkis AS, Arap W, Pasqualini R. Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands. Cancer Cell. 2004; 6: 275-284. Abstract, PDF
Zurita AJ, Arap W, Pasqualini R. Mapping tumor vascular diversity by screening phage display libraries. J Control Release. 2003; 91: 183-186. Abstract, PDF
Tamm I, Trepel M, Cardó-Vila M, Sun Y, Welsh K, Cabezas E, Swatterthwait A, Arap W, Reed JC, Pasqualini R. Peptides targeting caspase inhibitors. J Biol Chem. 2003; 278: 14401-14405. Abstract, PDF
Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, Korgel B, Descour M, Pasqualini R, Arap W, Lam W, Richards-Kortum R. Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat. 2003; 2: 491-504. Abstract, PDF
Pentz RD, Flamm AL, Pasqualini R, Logothetis CJ, Arap W. Revisiting ethical guidelines for research with terminal wean and brain-dead participants. Hastings Cent Rep. 2003; 33: 20-26. Abstract, PDF
Müller OJ, Kaul F, Weitzman MD, Pasqualini R, Arap W, Kleinschmidt JA, Trepel M. Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors. Nat Biotechnol. 2003; 21: 1040-1046. Abstract, PDF
Mintz PJ, Kim J, Do KA, Wang X, Zinner RG, Cristofanilli M, Arap MA, Hong WK, Troncoso P, Logothetis CJ, Pasqualini R, Arap W. Fingerprinting the circulating repertoire of antibodies from cancer patients. Nat Biotechnol. 2003; 21: 57-63. Abstract, PDF
Kontoyiannis DP, Pasqualini R, Arap W. Aminopeptidase N inhibitors and SARS.Lancet. 2003; 361: 1558. Abstract, PDF
Ellerby HM, Lee S, Ellerby LM, Chen S, Kiyota T, del Rio G, Sugihara G, Sun Y, Bredesen DE, Arap W, Pasqualini R. An artificially designed pore-forming protein with anti-tumor effects. J Biol Chem. 2003; 278: 35311-35316. Cover, Abstract, PDF
Cardó-Vila M, Arap W, Pasqualini R. Alpha v beta 5 integrin-dependent programmed cell death triggered by a peptide mimic of annexin V. Mol Cell. 2003; 11: 1151-1162. Abstract, PDF
Ardelt PU, Wood CG, Chen L, Mintz PJ, Moya C, Arap MA, Wright KC, Pasqualini R, Arap W. Targeting urothelium: ex vivo assay standardization and selection of internalizing ligands. J Urol. 2003; 169: 1535-1540. Abstract, PDF
Trepel M, Arap W, Pasqualini R. In vivo phage display and vascular heterogeneity: implications for targeted medicine. Curr Opin Chem Biol. 2002; 6: 399-404. Abstract, PDF
Pasqualini R, Barbas CF 3rd, Arap W. Vessel maneuvers: zinc fingers promote angiogenesis. Nat Med. 2002; 8: 1353-1354. Abstract, PDF
Pasqualini R, Arap W, McDonald DM. Probing the structural and molecular diversity of tumor vasculature. Trends Mol Med. 2002; 8: 563-571. Abstract, PDF
Pasqualini R, Arap W. Translation of vascular diversity into targeted therapeutics. Ann Hematol. 2002; 81 Suppl 2: S66-67. Abstract
Pasqualini R, Arap W. Profiling the molecular diversity of blood vessels. Cold Spring Harb Symp Quant Biol. 2002; 67: 223-225. Abstract
Kolonin MG, Pasqualini R, Arap W. Teratogenicity induced by targeting a placental immunoglobulin transporter. Proc Natl Acad Sci U S A. 2002; 99: 13055-13060. Abstract, PDF
Curnis F, Arrigoni G, Sacchi A, Fischetti L, Arap W, Pasqualini R, Corti A. Differential binding of drugs containing the NGR motif to CD13 isoforms in tumor vessels, epithelia, and myeloid cells. Cancer Res. 2002; 62: 867-874. Abstract, PDF
Arap W, Kolonin MG, Trepel M, =Lahdenranta J, Cardó-Vila M, Giordano RJ, Mintz PJ, Ardelt PU, Yao VJ, Vidal CI, Chen L, Flamm A, Valtanen H, Weavind LM, Hicks ME, Pollock RE, Botz GH, Bucana CD, Koivunen E, Cahill D, Troncoso P, Baggerly KA, Pentz RD, Do KA, Logothetis CJ, Pasqualini R. Steps toward mapping the human vasculature by phage display. Nat Med. 2002; 8: 121-127. Abstract, PDF
Arap W, Haedicke W, Bernasconi M, Kain R, Rajotte D, Krajewski S, Ellerby HM, Bredesen DE, Pasqualini R, Ruoslahti E. Targeting the prostate for destruction through a vascular address. Proc Natl Acad Sci U S A. 2002; 99: 1527-1531. Abstract, PDF
Greco G, Pal S, Pasqualini R, Schnapp LM. Matrix fibronectin increases HIV stability and infectivity. J Immunol. 2002; 168: 5722-5729. Abstract, PDF
Trepel M, Arap W, Pasqualini R. Modulation of the immune response by systemic targeting of antigens to lymph nodes. Cancer Res. 2001; 61: 8110-8112. Abstract, PDF
Pasqualini R, McDonald DM, Arap W. Vascular targeting and antigen presentation.Nat Immunol. 2001; 2: 567-568. Abstract, PDF
Lahdenranta J, Pasqualini R, Schlingemann RO, Hagedorn M, Stallcup WB, Bucana CD, Sidman RL, Arap W. An anti-angiogenic state in mice and humans with retinal photoreceptor cell degeneration. Proc Natl Acad Sci U S A. 2001; 98: 10368-10373. Abstract, PDF
Hoffman M, Olson K, Cavender A, Pasqualini R, Gaikwad J, D'Souza R. Gene expression in a pure population of odonoblasts isolated by laser-capture microdissection. J Dent Res. 2001; 80: 1963-1967. Abstract
Grifman M, Trepel M, Speece P, Gilbert LB, Arap W, Pasqualini R, Weitzman MD. Incorporation of tumor-targeting peptides into recombinant adeno-associated virus capsids. Mol Ther. 2001; 3: 964-975. Abstract, PDF
Kolonin M, Pasqualini R, Arap W. Molecular addresses in blood vessels as targets for therapy. Curr Opin Chem Biol. 2001; 5: 308-313. Abstract, PDF
Giordano RJ, Cardó-Vila M, Lahdenranta J, Pasqualini R, Arap W. Biopanning and rapid analysis of selective interactive ligands. Nat Med. 2001; 7: 1249-1253. Abstract, PDF
Cardó-Vila M, Arden KC, Cavenee WK, Pasqualini R, Arap W. Is annexin 7 a tumor suppressor gene in prostate cancer? Pharmacogenomics J. 2001; 1: 92-94. Abstract
Bhagwat SV, Lahdenranta J, Giordano RJ, Arap W, Pasqualini R, Shapiro LH. CD13/APN is activated by angiogenic signals and is essential for capillary tube formation. Blood. 2001; 97: 652-659. Abstract, PDF
Arap W, Pasqualini R. The human vascular mapping project. Selection and utilization of molecules for tumor endothelial targeting. Haemostasis. 2001; 31 Suppl 1: 30-31. Abstract
Trepel M, Arap W, Pasqualini R. Exploring vascular heterogeneity for gene therapy targeting. Gene Ther. 2000; 7: 2059-2060. Abstract, PDF
Tellier MC, Greco G, Klotman M, Mosoian A, Cara A, Arap W, Ruoslahti E, Pasqualini R, Schnapp LM. Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes. J Immunol. 2000; 164: 3236-3245. Abstract, PDF
Pasqualini R, Koivunen E, Kain R, Lahdenranta J, Sakamoto M, Stryhn A, Ashmun RA, Shapiro LH, Arap W, Ruoslahti E. Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis. Cancer Res. 2000; 60: 722-727. Abstract, PDF
Ogawa K, Pasqualini R, Lindberg RA, Kain R, Freeman AL, Pasquale EB. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene. 2000; 19: 6043-6052. Abstract, PDF
Fukuda MN, Ohyama C, Lowitz K, Matsuo O, Pasqualini R, Ruoslahti E, Fukuda M. A peptide mimic of E-selectin ligand inhibits sialyl Lewis X-dependent lung colonization of tumor cells. Cancer Res. 2000; 60: 450-456. Abstract, PDF
Schneller M, Arap W, Pasqualini R. Immunoblotting of integrins. Methods Mol Biol. 1999; 129: 63-78. Abstract
Koivunen E, Arap W, Rajotte D, Lahdenranta J, Pasqualini R. Identification of receptor ligands with phage display peptide libraries. J Nucl Med. 1999; 40: 883-888. Abstract
Koivunen E, Arap W, Valtanen H, Rainisalo A, Medina OP, Heikkila P, Kantor C, Gahmberg CG, Salo T, Konttinen YT, Sorsa T, Ruoslahti E, Pasqualini R. Tumor targeting with a selective gelatinase inhibitor. Nat Biotechnol. 1999; 17: 768-774. Abstract, PDF
Koivunen E, Restel BH, Rajotte D, Lahdenranta J, Hagedorn M, Arap W, Pasqualini R. Integrin-binding peptides derived from phage display libraries. Methods Mol Biol. 1999; 129: 3-17. Abstract
Ellerby HM, Arap W, Ellerby LM, Kain R, Andrusiak R, Rio GD, Krajewski S, Lombardo CR, Rao R, Ruoslahti E, Bredesen DE, Pasqualini R. Anti-cancer activity of targeted pro-apoptotic peptides. Nat Med. 1999; 5: 1032-1038. Cover, Abstract, PDF
Burg MA, Pasqualini R, Arap W, Ruoslahti E, Stallcup WB. NG2 proteoglycan-binding peptides target tumor neovasculature. Cancer Res. 1999; 59: 2869-2874. Abstract, PDF
Arap W, Huang HJ. Expression of integrin transcripts in human cancer cells. Methods Mol Biol. 1999; 129: 91-101. Abstract
Invited Articles
Sergeeva A, Kolonin MG, Molldrem JJ, Pasqualini R, Arap W. Display technologies: application for the discovery of drug and gene delivery agents. Adv Drug Deliv Rev. 2006; 58: 1622-1654. Abstract, PDF
Hajitou A, Pasqualini R, Arap W. Vascular targeting: recent advances and therapeutic perspectives. Trends Cardiovasc Med. 2006; 16: 80-88.
Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, Korgel B, Descour M, Pasqualini R, Arap W, Lam W, Richards-Kortum R. Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res. Treat 2003; 2: 491-504. Abstract, PDF
Zurita AJ, Arap W, Pasqualini R. Mapping tumor vascular diversity by screening phage display libraries. J Control Release. 2003; 91: 183-186. Abstract, PDF
Pasqualini R, Arap W, McDonald DM. Probing the structural and molecular diversity of tumor vasculature. Trends Mol Med. 2002; 8: 563-571. Abstract, PDF
Pasqualini R, Barbas CF 3rd, Arap W. Putting a Finger on Angiogenesis. Nat Med. 2002.
Pasqualini R, Arap W. Translation of vascular diversity into targeted therapeutics. Ann Hematol. 2002; 81 Suppl 2: S66-67. Abstract
Trepel M, Pasqualini R, Arap W. In vivo phage display and vascular heterogeneity: implications for targeted medicine. Curr Opin Chem Biol. 2002; 6: 399-404. Abstract, PDF
Kolonin M, Pasqualini R, Arap W. Molecular addresses in blood vessels as targets for therapy. Curr Opin Chem Biol. 2001; 5: 308-313. Abstract, PDF
Arap W, Pasqualini R. The human vascular mapping project. Selection and utilization of molecules for tumor endothelial targeting. Haemostasis. 2001; 31 Suppl 1: 30-31. Abstract
Koivunen E, Restel BH, Rajotte D, Lahdenranta J, Hagedorn M, Arap W, Pasqualini R. Integrin-binding peptides derived from phage display libraries. Methods Mol Biol. 1999; 129: 3-17. Abstract
Koivunen E, Arap W, Rajotte D, Lahdenranta J, Pasqualini R. Identification of receptor ligands with phage display peptide libraries. J Nucl Med. 1999; 40: 883-888. Abstract
Schneller M, Arap W, Pasqualini R. Immunoblotting of integrins. Methods Mol Biol. 1999; 129: 63-78. Abstract
Arap W, Huang HJ. Expression of integrin transcripts in human cancer cells. Methods Mol Biol. 1999; 129: 91-101. Abstract
Pasqualini R. Vascular targeting with phage peptide libraries. Q J Nucl Med. 1999; 43: 159-162. Abstract
Arap W, Pasqualini R, Ruoslahti E. Chemotherapy targeted to tumor vasculature. Curr Opin Oncol. 1998; 10: 560-565. Abstract
Pasqualini R, Ruoslahti E. Tissue targeting with phage peptide libraries. Mol Psychiatry. 1996; 1: 423. Abstract
Pasqualini R, Ruoslahti E. Searching for a molecular address in the brain. Mol Psychiatry. 1996; 1: 421-422. Abstract
Arap W, Huang HJ, Cavenee WK. Cancer genetics and tumor suppression. J Br Assoc Adv Sci. 1994; 46: 18-33.
Editorials
Arap W, Pasqualini R. Engineered embryonic endothelial progenitor cells as therapeutic Trojan horses. Cancer Cell. 2004; 5: 406-408. Abstract, PDF
Kontoyiannis DP, Pasqualini R, Arap W. Aminopeptidase N inhibitors and SARS. Lancet. 2003; 361: 1558. Abstract, PDF
Pasqualini R, Barbas CF 3rd, Arap W. Vessel maneuvers: zinc fingers promote angiogenesis. Nat Med. 2002; 8: 1353-1354. Abstract, PDF
Pasqualini R, McDonald DM, Arap W. Vascular targeting and antigen presentation. Nat Immunol. 2001; 2: 567-568. Abstract, PDF
Cardó-Vila M, Arden KC, Cavenee WK, Pasqualini R, Arap W. Is annexin 7 a tumor suppressor gene in prostate cancer? Pharmacogenomics J. 2001; 1: 92-94. Abstract
Trepel M, Arap W, Pasqualini R. Exploring vascular heterogeneity for gene therapy targeting. Gene Ther. 2000; 7: 2059-2060. Abstract, PDF
Book Chapters
Trepel M, Arap W, Pasqualini R. Selection, isolation, and identification of targeting peptides for ligand-directed gene delivery. Phage Display: A Laboratory Manual, New York: Cold Spring Harbor Laboratory Press. (In Press)
Christianson DR, Ozawa MG, Pasqualini R, Arap W. Techniques to decipher molecular diversity by phage display. In: Cardiovascular Proteomics Book in Methods in Molecular Biology. Humana Press. (In Press)
Zurita AJ, Arap W, Pasqualini R. Molecular Characterization of the Endothelium: A Phage Display Perspective. In: Aird WC, eds. Endothelial Biomedicine: A Comprehensive Reference. Cambridge University Press. Description
Lahdenranta J, Arap W, Pasqualini R. The use of proteomics to map phenotypic heterogeneity of the endothelium. In: Aird WC, eds. Endothelial Cell In Health And Disease. Taylor & Francis, 2005: 105-119.
Arap W, Pasqualini R. Mapping human vasculature. In: Pasqualini R, Arap W, eds. Protein Discovery Technologies, Principles, Methods and Applications. Marcel Dekker/CRC Press, New York. (In Press)
Cardó-Vila M, Vidal CI, Lahdenranta J, Arap W, Pasqualini R. Blood vessels as a target for cancer therapy. In: Syrigos, Harrington, eds. Targeted Therapy for Cancer. (In Press)
Vidal CI, Cardó-Vila M, Lahdenranta J, Arap W, Pasqualini R. Targeting blood vessels in vivo by using phage display libraries. In: Syringos KN, Harrington KJ, eds. Targeted Therapy for Cancer. New York: Oxford University Press Inc, 2003: 250-255.
Kolonin M, Pasqualini R, Arap W. Mapping human vascular heterogeneity by in vivo phage display. In: Hoying JB, eds. Genetics of Angiogenesis. BIOS Scientific Publishers Ltd, Oxford, 2003: 181-187.
Pasqualini R, Arap W. Profiling the molecular diversity of blood vessels. In: Spring Harbor Symposia on Quantitative Biology, 2002; 67: 223-225.
Pasqualini R, Arap W. Vascular Targeting. In: Encyclopedia of Cancer. 2nd ed. Academic Press Inc, New Brunswick, NJ, 2002; 4: 501-507.
Pasqualini R, Arap W. Translation of vascular proteomics into individualized therapeutics. In: Licinio J, Wong ML, eds. Pharmacogenomics: The Search for Individualized Therapies. Wiley-VCH Press, 2002: 525-530.
Pasqualini R, Arap W. Phage displayed peptides as tools to explore vascular heterogeneity. In: Martinez J, Fehrentz JA, eds. Peptides. EPS/Edicion EDK, 2001: 26-30.
Schneller M, Arap W, Pasqualini R. Immunoblotting of integrins. In: Howlett AR, eds. Meth Mol Biol. Humana Press Inc, 1999; 129: 63-78.
Koivunen E, Restel BH, Rajotte D, Lahdenranta J, Hagedorn M, Arap W, Pasqualini R. Integrin-binding peptides derived from phage display libraries. In: Howlett AR, eds. Meth Mol Biol. Humana Press Inc, 1999; 129: 3-17.
Hemler M, Weitzman J, Pasqualini R, Kawaguchi S, Kassner P, Berdichevsky F. Structure, biochemical properties, and biological functions of integrin cytoplasmic domains. In: The integrin: the biological problems. CRC Press Inc, Boca Raton FL, 1994: 1-35.
Hemler M, Bodorova J, Pasqualini R. Adhesion structures: CD29. In: Leukocyte typing V, A.S. 4/72. Oxford University Press, Oxford, 1994.
Brentani RR, Pasqualini R. Receptor purification using the hydropathy complementary approach. In: Receptor Purification. The Humana Press Inc, 1990; 1: 451-457.
Books
Pasqualini R, Arap W. Protein Discovery Technologies, Principles, Methods and Applications. Marcel Dekker/CRC Press, New York. (In Press)
Manuals and Other Publications
Pasqualini R, Arap W, Rajotte D, Ruoslahti E. In vivo selection of phage-display libraries. In: Barbas CF 3rd, Burton DR, Scott JK, Silverman, GJ, eds. Phage Display: A Laboratory Manual. New York: Cold Spring Harbor Laboratory Press, 2000: 1-24.
Manuscripts Featured in Journal Covers and Captions
Reversal of Obesity
Cover Caption (pdf), PDF, News and Media Releases
Combinatorial Screening in Patients: IL-11 Receptor as a Tumor Target
Featured Cover (pdf), PDF, News and Media Releases
An Artificially Designed Anti-tumor Protein
Featured Cover (pdf), PDF, News and Media Releases
Molecular Map of the Human Vasculature System
Cover Caption (pdf), PDF, News and Media Releases