Transgenic Animal Core
The Transgenic Animal Core provides Science Park investigators with a cost-effective means of developing genetically engineered animal models. Our services include:
- Generation of transgenic mouse founders by pronuclear microinjection of DNA constructs into fertilized FVB embryos (or other strains as needed)
- Generation of chimeric mice by blastocyst injection of gene-targeted ES cell lines
- Rederivation of transgenic and other specialized mouse strains by embryo transfer
- Archival storage of frozen embryos and sperm from transgenic and other specialized mouse strains
- Gene knockout and knock-in mouse models using zinc-finger nuclease technology
- Consultation, technical support and training to investigators wishing to establish their own genetically modified animals
Staff
David Johnson, Ph.D.
Professor
Director, Transgenic Animal Core
Phone: (512) 237-9511
Email: djohnson@mdanderson.org
Debra Hollowell
Lab Manager
Phone: (512) 237-9499
Email: dghollow@mdanderson.org