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Transgenic Animal Core

The Transgenic Animal Core provides Science Park investigators with a cost-effective means of developing genetically engineered animal models. Our services include:

  • Generation of transgenic mouse founders by pronuclear microinjection of DNA constructs into fertilized FVB embryos (or other strains as needed)
  • Generation of chimeric mice by blastocyst injection of gene-targeted ES cell lines
  • Rederivation of transgenic and other specialized mouse strains by embryo transfer
  • Archival storage of frozen embryos and sperm from transgenic and other specialized mouse strains
  • Gene knockout and knock-in mouse models using zinc-finger nuclease technology
  • Consultation, technical support and training to investigators wishing to establish their own genetically modified animals

Staff

David Johnson, Ph.D.
Professor
Director, Transgenic Animal Core
Phone: (512) 237-9511
Email: djohnson@mdanderson.org

Debra Hollowell
Lab Manager
Phone: (512) 237-9499
Email: dghollow@mdanderson.org


© 2014 The University of Texas MD Anderson Cancer Center