Epigenetics and Molecular Carcinogenesis Faculty
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Faculty Spotlight: Kevin McBride, Ph.D.
The McBride lab studies the role of activation induced deaminase (AID) in antibody diversification and cancer development. Normally, DNA damage is considered detrimental to genomic stability. However, activation induced deaminase (AID) induces DNA double-stranded breaks (DSBs) and mutations (hypermutation) that are critical for leading to antibody diversity to help fight infectious disease. Yet, AID can also induce unintended DNA damage, including point mutations in oncogenes and chromosome translocations leading to B-cell leukemias and lymphomas. Understanding how AID chooses its targets is fundamental to understanding how it causes deleterious DSBs. Learn more about Dr. McBride's research.