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Clinical Trials

Last Updated: September 10, 2012

This is a list of clinical trials and research protocols underway that will help us study thryoid malignancies and other endocrine neoplasias. If you would like to participate in one of the trials, please call the Information Line toll-free at 1-800-392-1611 or askMDAnderson at 1-877-632-6789. For information on other clinical trials, please visit MD Anderson's Clinical Trials Web site.

Thyroid Cancer

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of E7080 in 131I-Refractory Differentiated Thyroid Cancer
Protocol 2011-0035

The goal of this clinical research study is to compare the Progression-free Survival (PFS) of subjects with 131 I-refractory differentiated thyroid cancer (DTC) with radiographic evidence of disease progression within the prior 12 months treated with E7080 versus Placebo.

An Open-Label, Multicenter Phase II Study of the BRAF inhibitor Vemurafenib in Patients with Metastatic or Unresectable Papillary Thyroid Cancer (PTC) positive for the BRAF V600 Mutation and Resistant to Radioactive Iodine
Protocol 2011-0448

The goal of this clinical research study is to learn if vemurafenib can help to control papillary thyroid cancer.  The drug's effect on biomarkers will also be studied.

A Phase II trial using RAD001 for patients with radioiodine refractory thyroid cancer.  
Protocol 2010-0049

The goal of this clinical research study is to learn if RAD001 can help to control locally-advanced or metastatic thyroid cancer.

Vandetanib in Medullary Thyroid Cancer 
Protocol 2011-1097

The goal of this clinical research study is to compare how effective 2 different doses of vandetanib may be in helping to control medullary thyroid cancer .

Pituitary Tumors

ACROSTUDY - A Multicenter, Post Marketing Surveillance Study of Somavert Therapy in Patients with Acromegaly in the US and Europe
Protocol 2005-0222

The goal of this clinical research study is to look at the safety and effectiveness of long-term pegvisomant treatment for acromegaly

Other Endocrine Neoplasias, Including Solid Tumors

There are no clinical trials currently open for patients at the moment.

Other MD Anderson Clinical Trials Relevant to Endocrine Neoplasia Patients

A Single-arm, Multicenter, Proof-of-concept Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects with Elevated Serum Calcium Despite Recent Treatment with IV Bisphosphonates.
Protocol 2009-0595

The goal of this clinical research study is to learn if denosumab can help to control hypercalcemia in patients with cancer.

 

Download a PDF copy of the Department of Endocrine Neoplasia & HD's clinical trials flyer


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