Skip to Content

Clinical Trials

The division of Radiation Oncology offers clinical trials to test new radiation treatments for a variety of cancers. This list is a sample of the many ongoing clinical trials. 

Updated 3/21/12

Breast Cancer

2010-0559:  Randomized Trial of Hypofractionated Whole Breast Irradiation Versus Conventionally Fractionated Whole Breast Irradiation for Ductal Carcinoma in Situ and Early Invasive Breast Cancer

The goal of this clinical research study is to compare how 4 weeks of radiation treatment affects the breast to how 6 weeks of radiation treatment affects the breast. Researchers also want to know about other side effects of radiation.

RTOG 0413 A Randomized Phase III Study of Conventional Breast Irradiation (WBI) versus Partial Breast Irradiation (PBI) for Women with Stage 0, I, or II Breast Cancer

The goal of this clinical research study is to see if a 1-week course of partial breast irradiation is more effective than a 6-week course of whole breast radiation treatment for keeping cancer from coming back in the breast while keeping a good cosmetic outcome.

RTOG 1014:  A Phase II study of repeat breast preserving surgery and 3-D Conformal Partial Breast Re-Irradiation (PBRI) for Local Recurrence of Breast Carcinoma

The goal of this study is to learn more about the side effects of partial breast re-irradiation given after a lumpectomy.

Central Nervous System/Pediatric Cancers

ECOGE3F05: Phase III Study of Radiation Therapy with or without Temozolomide for Symptomatic or Progressive Low-Grade Gliomas

This study is for patients with symptomatic or progressive low-grade gliomas. The study is designed to determine if these patients have improved outcomes if they are treated with radiation therapy together with temozolomide followed by temozolomide, as compared to patients treated with radiation therapy who do not receive any temozolomide.  

2009-0381: Efficacy of Post-Surgical Stereotactic Radiosurgery for Metastatic Brain Disease: A Randomized Trial

The goal of this clinical research study is to learn if stereotactic radiosurgery can help to reduce the risk of a brain tumor returning after surgery. The safety of this treatment will also be studied.

2011-0804 Phase I/II study of reirradiation of recurrent or progressive brainstem glioma

The goal of this clinical research study is to find a safe dose of radiation that can be given to patients with brainstem glioma who have already received radiation therapy. You will receive photon radiation therapy. This type of radiation is similar to the radiation you have already had. Conformal radiotherapy or intensity modulated radiotherapy (IMRT) will be used to try to treat the tumor while affecting as little of the surrounding normal tissue as possible.

PCR05-0208: Data Collection of Normal Tissue Toxicity for Proton Therapy for Pediatrics

The goal of this research study is to collect information on the side effects of proton therapy and the details of proton treatment plans so that researchers can develop a method to predict the risk of side effects and to improve the planning and delivery of proton treatment for patients in the future.

RTOG 0631:  Phase II/III Study of Image-Guided Radiosurgery/SBRT For Localized Spine Metastasis

This randomized phase II/III trial is studying how well image-guided radiosurgery or stereotactic body radiation therapy works and compares it to external-beam radiation therapy in treating patients with localized spine metastasis. (phase II completed as of 8-30-11)

Gastrointestinal

SWOG0809:  A PhaseII Trial Of Adjuvant Capecitabine/Gemcitabine Chemotherapy Followed By Concurrent Capecitabine and Radiotherapy In Extrahepatic Cholangiocarcinoma (EHCC)

This phase II trial is studying how well giving capecitabine together with gemcitabine followed by capecitabine and radiation therapy works in treating patients with cholangiocarcinoma of the gallbladder or bile duct.

RTOG0848:  A Phase III Trial Evaluating Both Erlotinib and Chemoradiation as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma

This randomized phase III trial is studying gemcitabine hydrochloride and erlotinib hydrochloride to see how well they work compared with gemcitabine hydrochloride alone followed by the same chemotherapy regimen with or without radiation therapy and capecitabine or fluorouracil in treating patients with pancreatic cancer that was removed by surgery.

2009-0556:  Phase II Study of Proton Beam Irradiation for the Treatment of Unresectable Hepatocellular Cancer and Cholangiocarcinoma

The goal of this clinical research study is to learn if proton beam radiation therapy can shrink or slow the growth of the disease in patients with liver cancer. The safety of this treatment will also be studied.

RTOG1102 A Phase I Study of Induction Ganitumab (IND #113278) and Gemcitabine, followed by Ganitumab, Capecitabine, and 3D-Conformal Radiation Therapy (3D-CRT) with Subsequent Maintenance Therapy for Locally Advanced Pancreatic Cancer

The goal of this clinical research study is to learn the highest tolerable dose of ganitumab that can be combined with standard chemotherapy (gemcitabine and capecitabine) and radiation for patients with locally-advanced pancreatic cancer. The safety of this combination will also be studied. Ganitumab is a protein that can attach to a very specific part of a cell, which may cause cancer cells to die.
Gemcitabine is designed to block the growth of cancer cells, which may cause cancer cells to die. Capecitabine is designed to interfere with the growth of cancer cells.    

Genitourinary Cancers

RTOG 0232 A Phase III Study Comparing Combined External Beam Radiation Transperineal Interstitial Permanent Brachytherapy with Brachytherapy Alone for Selected Patients with Intermediate Risk Prostatic Carcinoma

The goal of this clinical research study is to compare the effects of external radiation treatments given before an internal radiation treatment, compared to an internal radiation treatment alone. The internal radiation treatment is brachytherapy (also known as implant therapy). The external radiation treatment is external beam radiation. This will be tested in patients with prostate cancer. The safety and level of effectiveness of these treatments will be compared, as well as participants' quality of life after treatment.

2005-0956 Prospective evaluation of quality of life after proton therapy for prostate cancer

The goal of this research study is to collect information on the side effects of proton radiation therapy given for the treatment of prostate cancer as well as the effect of proton therapy on quality of life. Information on your treatment and how you react to the treatment will be collected. Researchers will use this information to try to understand how people tolerate proton radiation therapy for prostate cancer.

2007-0302:  A Comprehensive, Multimodality Quality of Life Study for Prostate Cancer

The goal of this behavioral research study is to look at patients' quality of life after treatment or management for prostate cancer.

Gynecologic Cancers

RTOG 0724:  Phase III Randomized study of concurrent chemotherapy and pelvic radiation therapy with or without adjuvant chemotherapy in high-risk patients with early-stage cervical carcinoma following radical hysterectomy

The goal of this clinical research study is to learn if the addition of carboplatin and paclitaxel to cisplatin and radiation can help to control cervical cancer better than cisplatin and radiation alone.

Lymphoma

2010-0035:  Radiation Therapy Followed by Chemotherapy for Newly Diagnosed Patients with Stage I/II Nasal NK Cell Lymphoma

The goal of this clinical research study is to learn if radiation therapy and chemotherapy can help control stage 1 and/or 2 NK cell lymphoma. The safety of radiation and chemotherapy will also be studied.

Thoracic

2008-0133A Bayesian randomized trial of Image-Guided Adaptive Conformal Photon vs Proton Therapy, with Concurrent Chemotherapy, for Locally Advanced Non-Small Cell Lung Carcinoma: Treatment Related Pneumonitis and Locoregional Recurrence

The goal of this clinical research study is to learn if, compared with regular x-ray radiation, proton radiation reduces the risk of developing, treatment-related pneumonitis (TRP) or tumor recurrence (the tumor coming back in the irradiated area after treatment) in patients with lung cancer.

CALGB30610/RTOG 0538:  Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide
The goal of this clinical research study is to compare the effectiveness and safety of 3 different ways to give radiation therapy (2 experimental, 1 standard) in combination with chemotherapy to patients with small-cell lung cancer. The safety of these therapies and their effects on your quality of life will also be studied.

2005-0574:  Phase II stereotactic body radiotherapy for stage I (T1-T2, N0, M0), selective stage II (chest wall T3, N0M0) or isolated peripheral lung recurrent Non-Small Cell Lung Cancer (NSCLC)
The goal of this clinical research study is to learn if stereotactic body radiotherapy (SBRT) can help to control NSCLC. The safety of SBRT will also be studied.

2009-0847 Phase I Study of Evaluating the Safety of Using a Simultaneous Integrated Boost for Dose Escalation in Patients with Esophageal Cancer
The goal of this clinical research study is to find the highest tolerable dose of radiation that can be given in combination with docetaxel and 5-fluorouracil in patients with esophageal cancer that cannot be removed by surgery.

2007-0489Radiation Therapy and Cardiac Biomarkers
The goal of this clinical research study is to learn if the radiation that you are receiving will result in an increase in certain proteins produced by the heart called cardiac biomarkers.

2010-0164Phase I Study of Hypofractionated Proton Radiation Therapy in Thoracic Malignancies
The goal of this clinical research study is to study the safety of giving larger daily doses of proton radiation therapy than the standard dose levels given to treat lung cancer. Researchers want to find the highest daily dose of proton radiation that can be given without having to stop therapy due to side effects.


© 2014 The University of Texas MD Anderson Cancer Center