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Clinical Trials

The division of Radiation Oncology offers clinical trials to test new radiation treatments for a variety of cancers. This list is a sample of the many ongoing clinical trials. 

Updated 6/16/14

Breast Cancer

NSABP B-51/RTOG1304: A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy

The main purpose of this clinical trial is to study women like you who have cancer cells in the lymph nodes at the time that the breast cancer is diagnosed and have chemotherapy before surgery that clears the cancer cells from the lymph nodes.  This study asks 1) if, after lumpectomy, radiation to the breast and lymph nodes will be better than radiation only to the breast at keeping breast cancer from returning, and 2) if, after mastectomy, radiation to the area where the breast used to be and to the lymph nodes is better than no radiation at keeping breast cancer from returning.

2008-0319: Aggressive Local Therapy for Limited Bone-only Metastasis to Improve Progression-Free Survival in Breast Cancer Patients

The goal of this clinical research study is to find out if adding local therapy (surgery and/or radiation) to standard therapy (chemotherapy or endocrine therapy) in the treatment of patients with metastatic breast cancer can help to control the disease for a longer period of time than standard therapy alone.

2009-0818: Assessing the efficacy and toxicity of partial breast irradiation using proton beam irradiation

The goal of this clinical research study is to find out if receiving a 1-week course of partial breast irradiation (PBI) using proton therapy will cause fewer and/or less severe side effects (such as changes to the appearance of the breast) than a longer course of radiation treatment.

2012-0399: A Phase I Study of Veliparib Administered Concurrently with Chest Wall and Nodal Radiation Therapy in Patients with Inflammatory or Loco-regionally Recurrent Breast Cancer

The goal of this clinical research study is to find the highest tolerable dose of veliparib that can be given with radiation to patients with breast cancer. The safety of this combination will also be studied.

Central Nervous System/Pediatric Cancers

2012-0190: A prospective study using implanted fiducial markers to assess treatment accuracy and esophageal toxicity in spinal stereotactic body radiation therapy

The goal of the first part of this clinical research study is to learn how to deliver more accurate radiation treatment of tumors in the spine.  Researchers also want to learn how internal organs might move during radiation treatment.  

The goal of the second part of this study is to learn if it is safe to allow slightly more radiation to the normal esophagus when spinal tumors close by are being treated.  This may result in better tumor control.

2013-0097:A prospective Phase II randomized trial to compare intensity modulated proton radiotherapy (IMPT) vs. intensity modulated radiotherapy (IMRT) for newly diagnosed Glioblastoma (WHO Grade IV)

The goal of this clinical research study is to compare IMRT with IMPT in patients with glioblastoma.  Researchers want to learn about cognitive side effects (mental status changes) that may occur, such as memory loss and impaired thinking.

2011-0172: Phase II Study of High Dose Intensity Modulated Proton Radiation Treatment + Surgical  Resection of Sarcomas of the Spine, Sacrum, and Base of Skull

The goal of this clinical research study is to learn if beam scanning proton radiation with or without intensity modulated radiation therapy (IMRT) can help to control chordomas of the spine, sacrum, or base of the skull or chondrosarcomas of the spine or sacrum.  The safety of this treatment will also be studied.

2004-0915: Phase II Evaluation of Proton Beam Therapy for Skull Base Chondrosarcoma

The goal of this clinical research study is to learn if proton beam therapy, with or without photon beam radiation therapy, is effective in the treatment of skull base chondrosarcoma.  The safety of this treatment will also be studied.

2010-0653: Feasibility of Single Session Spine Stereotactic Radiosurgery (SSRS) in the primary management of previously irradiated patients with inoperable metastatic epidural spinal cord compression (MESCC)

The goal of this clinical study is to learn the feasibility of using a single session of radiation, known as spine stereotactic radiosurgery (SSRS), to treat metastatic epidural spinal cord compression.

2010-0655: Phase I study of Feasibility of Single Session Spine Stereotactic Radiosurgery (SSRS) in the primary management in patients with inoperable, previously unirradiated metastatic epidural spinal cord compression (MESCC)

The goal of this clinical study is to learn the feasibility of using a single session of radiation, known as spine stereotactic radiosurgery (SSRS), to treat metastatic epidural spinal cord compression.

2011-0884: A prospective Phase III randomized trial to compare stereotactic radiosurgery vs. whole brain radiation therapy for >3 newly diagnosed non-melanoma brain metastases

The goal of this clinical research study is to compare stereotactic radiosurgery to whole brain radiation therapy in patients with 4-10 non-melanoma brain tumors.

2009-0381: Efficacy of Post-Surgical Stereotactic Radiosurgery for Metastatic Brain Disease: A Randomized Trial

The goal of this clinical research study is to learn if stereotactic radiosurgery can help to reduce the risk of a brain tumor returning after surgery. The safety of this treatment will also be studied.

2010-0489: A Phase II Study of Proton beam radiotherapy for medulloblastoma and pineoblastoma: an assessment of acute toxicity and long term neurocognitive, neuroendocrine and ototoxicity outcomes

The goal of this clinical research study is to learn about the safety of giving proton beam radiation therapy to the brain and spinal cord in patients with medulloblastoma or pineoblastoma who are between the ages of 3 and 25.  Researchers want to learn if proton therapy has fewer short and long-term side effects than a more standard type of radiation therapy (photon beam radiation therapy)

2011-0804: Phase I/II study of reirradiation of recurrent or progressive brainstem glioma

The goal of this clinical research study is to find a safe dose of radiation that can be given to patients with brainstem glioma who have already received radiation therapy.

2011-0875: A Prospective Randomized Phase III Trial to Compare Local Control and Neurocognitive Preservation after Initial Treatment with Stereotactic Radiosurgery (SRS) Versus Whole Brain Radiation Therapy (WBRT) for Patients with >3 Brain Metastases from Melanoma

The goal of this clinical research study is to compare stereotactic radiosurgery (SRS) to whole brain radiation therapy (WBRT) in patients with more than 3 melanoma brain tumors.

Gastrointestinal

2009-0556: Phase II Study of Proton Beam Irradiation for the Treatment of Unresectable Hepatocellular Cancer and Cholangiocarcinoma

The goal of this clinical research study is to learn if proton beam radiation therapy can shrink or slow the growth of the disease in patients with liver cancer.  The safety of this treatment will also be studied.

RTOG1112: Randomized Phase III Study of Sorafenib versus Stereotactic Body Radiation Therapy followed by Sorafenbi in Hepatocellular Carcinoma

The goal of this clinical research study is to compare the effects of sorafenib alone (the present standard of care treatment) with Stereotactic Body Radiation Therapy (SBRT) followed by sorafenib on you and your liver cancer to find out which is better. In this study, you will get either SBRT followed by sorafenib or the sorafenib alone.

Genitourinary Cancers

2007-0933: Prophylactic cranial irradiation (PCI) for patients with small cell carcioma of the urothelium

The goal of this clinical research study is to learn if whole brain radiation can lower the chances of developing brain tumors in patients with small cell carcinoma of the urinary tract, including the bladder. The safety of whole brain radiation will also be studied.

2008-0254: Radiation Therapy for Rising PSA Post-prostatectomy

The goal of this clinical research study is to create a registry (research database) of clinical data about patients who receive radiation therapy, with or without hormone therapy, to treat prostate cancer that has come back after surgical removal of the prostate.

2012-0104: Phase II study assessing the potential for reduced toxixity using focal brachytherapy in low-risk prostate cancer

The goal of this clinical research study is to learn about the side effects of focal brachytherapy when it is used to treat prostate cancer.  Researchers also want to learn how effective focal brachytherapy may be in controlling the disease and on your quality of life.

2012-1013: A Pilot Study for the Identification of MRI Markers in Prostate Brachytherapy

The goal of this clinical research study is to learn if magnetic resonance imaging (MRI) scans that are done at standard timepoints after brachytherapy can also be used to find the radiation seeds used to treat prostate cancer.

2012-1003: Phase II Trial of hypofractionated proton beam therapy in men with localized prostate adenocarcinoma

The goal of this clinical research study is to learn if delivering proton therapy in higher doses per treatment may help control prostate cancer just as well as the standard of care treatment.  The safety of this treatment will also be studied.

RTOG1115: Phase III trial of dose escalated radiation therapy and standard androgen deprivation therapy (ADT) with a GNRH agonist vs. dose escalated radiation therapy and enhanced ADT with a GNRH agonist and TAK-700 for men wihth high risk prostate cancer

The goal of this clinical research is to learn if adding TAK-700 to standard therapy (hormone therapy and radiation therapy) can better help to control prostate cancer than standard therapy alone.

Gynecologic Cancers

2012-0546: 3D Image-guided Intracavitary Brachytherapy Treatment Planning for Cervical Cancer using a Novel Shielded Applicator

The goal of this clinical research study is to learn if computed tomography (CT) and magnetic resonance imaging (MRI) images can better help to plan internal radiation treatment.

RTOG1203: A Randomized Phase III Study of Standard vs. IMRT Pelvic Radiation for Post-Operative Treatment of Endometrial and Cervical Cancer (TIME-C)

The goal of this clinical research study is to find out if using a radiation delivery method called intensity-modulated radiation therapy (IMRT) leads to fewer and/or less severe gastrointestinal side effects (such as diarrhea) than standard radiation delivery.

Head and Neck

2012-0825: Phase III Randomized Trial of Intensity-Modulated Proton Beam Therapy (IMPT) versus Intensity-Modulated Photon Therapy (IMRT) for the treatment of Oropharyngeal Cancer of the Head and Neck Cancer

The goal of this clinical research study is to compare the side effects of 2 radiation treatments for head and neck cancer.  The 2 treatments are intensity modulated photon therapy (IMRT) and intensity modulated proton therapy (IMPT).  Participants may also receive chemotherapy along with radiation therapy.

2012-1127: Pilot Feasibility Study of Iron Oxide Nanoparticle Magnetic Resonance Dynamic Contrast Enhanced MRI for Primary and Nodal Tumor Imaging in Locally Advanced Head and Neck Squamous Cell Carcinomas

The goal of this clinical research study is to learn if ferumoxytol, when given at the time of a magnetic resonance imaging (MRI), can help researchers learn more about the spread of certain kinds of cancers.

2010-0557: Armodafinil for persistent patient-reported fatigue following radiation therapy for head and neck cancer: a randomized phase II study

The goal of this clinical research study is to learn if armodafinil can reduce fatigue and  other common symptoms in patients that have received treatment for head and neck cancer.

RTOG0912: A Randomized Phase II Study of Concurrent Intensity Modulated Radiation Therapy (IMRT), Paclitaxel and Pazopanib (NSC 737754)/Placebo, for the Treatment of Anaplastic Thyroid Cancer

The goal of this clinical research study is to learn if adding pazopanib to paclitaxel and radiation (chemoradiotherapy) is safe and tolerable.

RTOG3501: Tryhard: A Phase II, Randomized, Double Blind, Placebo-Controlled Study of Lapatinib (TYKERB) for Non-HPV Locally Advanced Head and Neck Cancer with Consurrent Chemoradiation

The goal of this clinical study is to compare the effects, good and/or bad, of chemoradiotherapy and lapatinib versus chemoradiotherapy and a non-active tablet (a placebo) on you and your head and neck cancer.

RTOG1016: Phase III Trial of Radiotherapy Plus Cetuximab Versus Chemoradiotherapy in HPV-Associated Oropharynx Cancer

The goal of this clinical research study is to compare the effects of 2 standard treatments for head and neck cancer.  The two standard treatments are (1) radiation therapy with cisplatin or (2) radiation therapy with cetuximab.  Researchers will compare any side effects and how well the treatments control the disease.

Lymphoma

2011-0283: Concurrent Radiation Therapy and Rituximab as front line treatment for patients with Stage I II Follicular Lymphoma grade I/II

The goal of this clinical research study is to learn if adding rituximab to radiation therapy will help control the disease better than radiation alone.  The safety of this combination will also be studied.

Thoracic

2011-0691: Randomized Phase II Study Comparing Stereotactic Body Radiotherapy (SBRT) with Stereotacic Body Proton Therapy (SBPT) for Centrally Located Stage I, Selected Stage II and Recurrent Non-Small Cell Lung Cancer

The goal of this clinical research study is to compare 2 types of radiotherapy, stereotactic body photon radiotherapy (SBRT) and stereotactic body proton radiotherapy (SBPT).  Researchers would like to compare the side effects, quality of life, and cancer control.

2012-0067: Phase III Randomized Study of Standard versus Accelerated Hypofractionated Image-Guided Radiation Therapy (IGRT) in Patients with Stage II-III Non-Small Cell Lung Cancer and Poor Performance Status

The goal of this clinical research study is to compare how 2 different dose schedules of radiation therapy may help to control NSCLC.  The safety of these treatments will also be studied.

2012-0618: A Randomized Phase II Study Assessing the Efficacy of Local Consolidative Therapy for Non-Small Cell Lung Cancer Patients with Oligometastatic Disease

The goal of this clinical research study is to learn if surgery or radiation after chemotherapy can help to control NSCLC.  The safety of this treatment will also be studied.

2012-0045: Phase II Toxicity Study Using Chemotherapy +/- Pleurectomy/Decortication Followed by Intensity Modulated Radiation Therapy to the Pleura in Patients with Locally Advanced Malignant Pleural Mesothelioma

The goal of this clinical research study is to test the safety and learn about the side effects of standard chemotherapy, with or without surgery to remove the surface lining of the lung,  followed by intensity modulated radiation therapy (IMRT) to the lining of the lung (pleura) in patients with malignant pleural mesothelioma. How well the addition of IMRT to standard therapy will also be measured.

2011-0631: An imaging study to compare methods to reduce 4DCT image acquisition artifacts

The goal of this clinical research study is to learn about ways to possibly reduce scanning errors when using 4-dimensional computed tomography (4D CT) scans to check lung function in patients with esophageal or lung cancer.

CALGB30610-RTOG0538: Phase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide

The goal of this clinical research study is to compare the effectiveness and safety of 2 different ways to give radiation therapy (1 experimental, 1 standard) in combination with chemotherapy to patients with small-cell lung cancer.  The safety of these therapies and their effects on your quality of life will also be studied.

2011-1058: Phase I/II trial of image-guided, intensity-modulated scanning beam proton therapy (IMPT) with simultaneous integrated boost (SIB) dose escalation to the gross tumor volume (GTV) with concurrent chemotherapy for stage II/III non-small cell lung cancer (NSCLC)

The goal of this clinical research study is to learn if the dose of radiation to the tumor but not the surrounding healthy tissue could be increased by using intensity-modulated photon therapy (IMRT) or intensity-modulated proton beam therapy (IMPT).

2011-1036: Phase III Randomized Trial of Proton Beam Therapy versus Intensity-Modulated Radiation Therapy for the treatment of esophageal cancer

The goal of this clinical research study is to learn how safe and effective proton-beam therapy (PBT) may be in comparison to intensity modulated radiation therapy (IMRT) in combination with chemotherapy in patients with esophageal cancer.

2012-1053: Phase I Study Combining MEK-Inhibitor GSK 1120212 to Chemoradiation for Locally Advanced Non-Small Cell Lung Cancer

The goal of this clinical research study is to find the highest tolerable dose of the experimental chemotherapy drug trametinib (GSK1120212) that can be combined with standard chemotherapy and radiation therapy, in patients who have lung cancer.

2012-0117: A Randomized Phase II Study of Minocycline and Armodafinil for Reducing the Symptom Burden Produced by Chemoradiation Treatment for Esophageal Cancer

The goal of this clinical research study is to compare armodafinil and minocycline when given alone or in combination to learn which is better for controlling side effects of chemoradiation treatment for esophageal cancer (such as fatigue, pain, disturbed sleep, lack of appetite, and drowsiness).

RTOG1308: Phase III Randomized Trial Comparing Overall Survival after Photon versus Proton Radiochemotherapy for Inoperable Stage II-IIIB NSCLC

The purpose of this study is to compare the good and bad effects of these two different types of radiation therapy in combination with FDA-approved chemotherapy for your type of lung cancer. Compared with photons, proton therapy can stop shortly after penetrating through the tumor and therefore may cause less damage to the surrounding healthy organs. This feature of proton therapy may allow doctors to deliver higher doses of radiation to the tumor.

2009-0847: Phase I Study of Evaluating the Safety of Using a Simultaneous Integrated Boost for Dose Escalation in Patients with Esophageal Cancer

The goal of this clinical research study is to find the highest tolerable dose of radiation that can be given in combination with chemotherapy in patients with esophageal cancer that cannot be removed by surgery.


© 2014 The University of Texas MD Anderson Cancer Center