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Zhenlin Ju, Ph.D.

Senior Statistical Analyst

Degrees

  • Ph.D. in Molecular Genetics, Auburn University, Auburn, AL
  • M.S. in Statistics, Auburn University, Auburn, AL
  • B.S. in Pathology, Shenyang Agricultural University, Shenyang, China

Areas of Interest

  • Bioinformatical data mining
  • Statistical analysis of genomic, proteomic and clinical data

Publications

Liang H, Cheung LW, Li J, Ju Z, Yu S, Stemke-Hale K, Dogruluk T, Lu Y, Liu X, Gu C, Guo W, Scherer SE, Carter H, Westin SN, Dyer MD, Verhaak RG, Zhang F, Karchin R, Liu CG, Lu KH, Broaddus RR, Scott KL, Hennessy BT, Mills GB. Whole-exome sequencing combined with functional genomics reveals novel candidate driver cancer genes in endometrial cancer. Genome Res 2012; 22(11): 2120-2129.

Fu S, Hennessy BT, Ng CS, Ju Z, Coombes KR, Wolf JK, Sood AK, Levenback CF, Coleman RL, Kavanagh JJ, Gershenson DM, Markman M, Dice K, Howard A, Li J, Li Y, Stemke-Hale K, Dyer M, Atkinson E, Jackson E, Kundra V, Kurzrock R, Bast RC Jr, Mills GB. Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer. Gynecol Oncol 2012; 126(1): 47-53.

Gonzalez-Angulo AM, Hennessy BT, Meric-Bernstam F, Sahin A, Liu W, Ju Z, Carey MS, Myhre S, Speers C, Deng L, Broaddus R, Lluch A, Aparicio S, Brown P, Pusztai L, Symmans WF, Alsner J, Overgaard J, Borresen-Dale AL, Hortobagyi GN, Coombes KR, Mills GB. Functional proteomics can define prognosis and predict pathologic complete response in patients with breast cancer. Clin Proteomics 2011; 8(1): 11.

Cheung WT, Hennessy BT, Li J, Yu S, Myers AP, Djordjevic B, Lu Y, Stemke-Hale K, Zhang F, Ju Z, Canttley LC, Scherer SE, Liang H, Lu KH, Broaddus RR, Mills GB. High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability. Cancer Discov 2011; 1(2): 170-85.

Hennessy BT, Lu Y, Gonzalez-Angulo AM, Carey MS, Myhre S, Ju Z, Davies MA, Liu W, Coombes K, Meric-Bernstam F, Bedrosian I, McGahren M, Agarwal R, Zhang F, Overgaard J, Alsner J, Neve RM, Kuo WL, Gray JW, Borresen Dale AL, Mills GB. A technical assessment of the utility of reverse phase protein arrays for the study of the functional proteome in non-microdissected human breast cancers. Clin Proteomics 2010; 6(4): 129-151.

Chen Y, Alvarez EA, Azzam D, Wander SA, Guggisberg N, Jorda M, Ju Z, Hennessy BT, Slingerland JM. Combined Src and ER blockade impairs human breast cancer proliferation in vitro and in vivo. Breast Cancer Res Treat 2010; 122: 381-393.

Tsao T, Kornblau S, Safe S, Watt JC, Ruvolo V, Chen W, Qiu Y, Coombes KR, Ju Z, Abdelrahim M, Schober W, Ling X, Kardassis D, Meyer C, Schimmer A, Kantarjian H, Andreeff M, Konopleva M. Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia. Cancer Res 2010; 70(12): 4949-4960.

Carey MS, Agarwal R,  Gilks B, Swenerton K, Kalloger S, Santos J,  Ju Z, Lu Y, Zhang F, Coombes K, Miller D, Gabra H, Brown R, Kaye S, Huntsman D, Mills G, Hennessy BT. Functional proteomic analysis of advanced serous ovarian cancer using reverse phase protein array: TGFβ pathway signaling indicates response to primary chemotherapy. Clin Cancer Res 2010; 16(10): 2852-2860.

Park ES,  Rabinovsky R, Carey M, Hennessy BT, Agarwal R,  Liu W, Ju Z, Deng W, Lu Y, Woo HG, Kim SB, Cheong JH, Garraway LA, Weinstein JN, Mills GB, Lee JS, Davies MA. Integrative analysis of proteomic signatures, mutations, and drug responsiveness in the NCI60 cancer cell line set. Mol Cancer Ther 2010; 9(2): 257-267.

Davies MA, Stemke-Hale K, Lin E, Tellez C, Deng W, Yennu VN, Woodman S, Calderone T, Ju Z, Lazar AJ, Prieto V, Aldape K, Mills GB, Gershenwald J. Integrated molecular and clinical analysis of AKT activation in metastatic melanoma. Clin Cancer Res 2009; 15(24): 7538-7546.

Zhang Z, Ju Z, Wells MC, Walter RB. Genomic approaches in the identification of hypoxia biomarkers in model fish species. J Exp Mar Biol Ecol 2009; 381(Supplement 1): S180-S187.

Boswell MG, Wells MC, Kirk LM, Ju Z, Zhang Z, Booth RE, Walter RB. Comparison of gene expression responses to hypoxia in viviparous (Xiphophorus) and oviparous (Oryzias) fishes using a medaka microarray. Comp Biochem Physiol C Toxicol Pharmacol 2009; 149: 258-265.

Sun H, Chung WC, Ryu SH, Ju Z, Tran HT, Kim E, Kurie JM, Koo JS. Cyclic AMP-responsive element binding protein- and nuclear factor-kappaB-regulated CXC chemokine gene expression in lung carcinogenesis. Cancer Prev Res (Phila) 2008; 1: 316-328.

Ju Z, Wells MC, Heater SJ, Walter RB. Multiple tissue gene expression analyses in Japanese medaka (Oryzias latipes) exposed to hypoxia. Comp Biochem Physiol C Toxicol Pharmacol 2007; 145: 134-144.

Ju Z, Wells MC, Walter RB. DNA microarray technology in toxicogenomics of aquatic models: methods and applications. Comp Biochem Physiol C Toxicol Pharmacol 2007; 145: 5-14.

Barboza JA, Liu G, Ju Z, El-Naggar AK, Lozano G. p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci USA 2006; 103(52): 19842-19847   

Ju Z, Wells MC, Martinez A, Hazlewood L, Walter RB. An in silico mining for simple sequence repeats from expressed sequence tags of zebrafish, medaka, Fundulus, and Xiphophorus. In Silico Biol 2005; 5(5-6): 439-463.

Ju Z, Kapoor M, Newton K, Cheon K, Ramaswamy A, Lotan R, Strong LC, Koo JS. Global detection of molecular changes reveals concurrent alteration of several biological pathways in nonsmall cell lung cancer cells. Mol Genet Genomics 2005; 274(2): 141-154.

Ramaswamy A, Lin E, Chen I, Mitra R, Morrisett J, Coombes K, Ju Z, Kapoor M. Application of protein lysate microarrays to molecular marker verification and quantification. Proteome Sci 2005; 3: 9.

Gold D, Coombes K, Medhane D, Ramaswamy A, Ju Z, Strong L, Koo JS, Kapoor M. A comparative analysis of data generated using two different target preparation methods for hybridization to high-density oligonucleotide microarrays. BMC Genomics 2004; 5(1): 2.

Ju Z, Dunham RA, Liu Z. Differential gene expression in the brain of channel catfish (Ictalurus punctatus) in response to cold acclimation. Mol Genet Genomics 2002; 268(1): 87-95.

Karsi A, Cao D, Li P, Patterson A, Kocabas A, Feng J, Ju Z, Mickett KD, Liu Z. Transcriptome analysis of channel catfish (Ictalurus punctatus): initial analysis of gene expression and microsatellite-containing cDNAs in the skin. Gene 2002; 285: 157-168.

Kocabas AM, Li P, Cao D, Karsi A, He C, Patterson A, Ju Z, Dunham RA, Liu Z. Expression profile of the channel catfish spleen: analysis of genes involved in immune functions. Mar Biotechnol (NY) 2002; 4: 526-536.

Cao D, Kocabas A, Ju Z, Karsi A, Li P, Patterson A, Liu Z. Transcriptome of channel catfish (Ictalurus punctatus): initial analysis of genes and expression profiles of the head kidney. Anim Genet 2001; 32: 169-188.

Liu Z, Li P, Kocabas A, Karsi A, Ju Z. Microsatellite-containing genes from the channel catfish brain: evidence of trinucleotide repeat expansion in the coding region of nucleotide excision repair gene RAD23B. Biochem Biophys Res Commun 2001; 289: 317-324.

Ju Z, Karsi A, Kocabas A, Patterson A, Li P, Cao D, Dunham R, Liu Z. Transcriptome analysis of channel catfish (Ictalurus punctatus): genes and expression profile from the brain. Gene 2000; 261: 373-382.

 

Updated March 8, 2013


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