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Lianchun Xiao, M.S.

Senior Statistical Analyst

Degree

  • M.S. in Statistics, University of Georgia, Athens, GA

 Areas of Interest

  • Bioinformatics
  • Data analysis
  • Statistical programming

Publications

2012

Kaseb AO, Garrett-Mayer E, Morris JS, Xiao L, Lin E, Onicescu G, Hassan MM, Hassabo HM, Iwasaki M, Deaton FL, Abbruzzese JL, Thomas MB. Efficacy of bevacizumab plus erlotinib for advanced hepatocellular carcinoma and predictors of outcome: final results of a phase II trial. Oncology 2012; 82(2): 67-74.

Cabanillas ME, Kantarjian H, Thomas DA, Mattiuzzi GN, Rytting ME, Bruera E, Xiao L, Bekele BN, Foudray MC, Cortes JE. Epoetin alpha decreases the number of erythrocyte transfusions in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, and Burkitt leukemia/lymphoma: results of a randomized clinical trial. Cancer 2012; 118(3): 848-855. 

2011

Sonpavde G, Aparicio AM, Zhan F, North B, Delaune R, Garbo LE, Rousey SR, Weinstein RE, Xiao L, Boehm KA, Asmar L, Fleming MT, Galsky MD, Berry WR, Von Hoff DD. Azacitidine favorably modulates PSA kinetics correlating with plasma DNA LINE-1 hypomethylation in men with chemonaïve castration-resistant prostate cancer. Urologic Oncology 2011; 29(6): 682-689.

Cabanillas ME, Kantarjian H, Thomas DA, Mattiuzzi GN, Rytting ME, Bruera E, Xiao L, Bekele BN, Foudray MC, Cortes JE. Epoetin alpha decreases the number of erythrocyte transfusions in patients with acute lymphoblastic leukemia, lymphoblastic lymphoma, and Burkitt leukemia/lymphoma: results of a randomized clinical trial. Cancer 2011; 118(3): 848-855.

Kim HN, Alousi AM, Lee JH, Qiao W, Xiao L, Ross WA. Role of ERCP in patients after hematopoietic stem cell transplantation. Gastrointestinal Endoscopy 2011; 74(4): 817-824.

Kaseb AO, Morris JS, Hassan MM, Siddiqui AM, Lin E, Xiao L, Abdalla EK, Vauthey JN, Aloia TA, Krishnan S, Abbruzzese JL. Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. Journal of Clinical Oncology 2011; 10(29):3892-3899. 

Wu AS, Witgert ME, Lang FF, Xiao L, Bekele BN, Meyers CA, Ferson D, Wefel JS. Neurocognitive function before and after surgery for insular gliomas. Journal of Neurosurgery 2011; 115(6): 1115-1125. 

Kaseb AO, Abbruzzese JL, Vauthey JN, Aloia TA, Abdalla EK, Hassan MM, Lin E, Xiao L, El-Deeb AS, Rashid A, Morris JS. I-CLIP: Improved stratification of advanced hepatocellular carcinoma patients by integrating plasma IGF-1 into CLIP Score. Oncology 2011; 80(5-6): 373-381.

Letourneau PA, Xiao L, Harting MT, Lally KP, Cox CS Jr, Andrassy RJ, Hayes-Jordan AA. Location of pulmonary metastasis in pediatric osteosarcoma is predictive of outcome. Journal of Pediatric Surgery 2011; 46(7): 1333-1337.

Suzuki A, Xiao L, Hayashi Y, Macapinlac HA, Welsh J, Lin SH, Lee JH, Bhutani MS, Maru DM, Hofstetter WL, Swisher SG, Ajani JA. Prognostic significance of baseline positron emission tomography and importance of clinical complete response in patients with esophageal or gastroesophageal junction cancer treated with definitive chemoradiotherapy. Cancer 2011; 117(21): 4823-4833.

Alatrash G, de Lima M, Hamerschlak N, Pelosini M, Wang X, Xiao L, Kerbauy F, Chiattone Md A, Rondon Md G, Qazilbash Md MH, Giralt SA, de Padua Silva L, Hosing C, Kebriaei P, Zhang W, Nieto Y, Saliba RM, Champlin RE, Andersson BS. Myeloablative reduced-toxicity i.v.busulfan-fludarabine and allogeneic hematopoietic stem cell transplant for patients with acute myeloid leukemia or myelodysplastic syndrome in the sixth through eighth decades of life. Biology of Blood and Marrow Transplantation 2011; 17(10): 1490–1496.

Letourneau PA, Shackett B, Xiao L, Trent J, Tsao KJ, Lally K, Hayes-Jordan A. Resection of pulmonary metastases in pediatric patients with Ewing sarcoma improves survival. Journal of Pediatric Surgery 2011; 46(2): 332-335.

Sivina M, Hartmann E, Kipps TJ, Rassenti L, Krupnik D, Lerner S, Lapushin R, Xiao L, Huang X, Werner L, Neuberg D, Kantarjian H, O'Brien S, Wierda WG, Keating MJ, Rosenwald A, Burger JA. CCL3 (MIP-1{alpha}) plasma levels and the risk for disease progression in chronic lymphocytic leukemia (CLL). Blood 2011; 117(5): 1662-1669.

Mattiuzzi GN, Cortes J, Alvarado G, Verstovsek S, Koller C, Pierce S, Blamble D, Faderl S, Xiao L, Hernandez M, Kantarjian H. Efficacy and safety of intravenous voriconazole and intravenous itraconazole for antifungal prophylaxis in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome. Support Care Cancer 2011;19(1): 19-26.

2010

Kaseb AO, Hassan MM, Lin E, Xiao L, Kumar V, Pathak P, Lozano R, Rashid A, Abbruzzese JL, Morris JS. V-CLIP: integrating plasma vascular endothelial growth factor into a new scoring system to stratify patients with advanced hepatocellular carcinoma for clinical trials. Cancer 2011; 117(11): 2478-2488.

Anaya DA, Lahat G, Wang X, Xiao L, Pisters PW, Cormier JN, Hunt KK, Feig BW, Lev DC, Pollock RE. Postoperative nomogram for survival of patients with retroperitoneal sarcoma treated with curative intent. Annals of Oncology 2010; 21(2): 397-402.

Hayes-Jordan A, Green H, Fitzgerald N, Xiao L, Anderson PJ. Novel treatment for desmoplastic small round cell tumor: hyperthermic intraperitoneal perfusion. Pediatric Surgery 2010; 45(5): 1000-1006.

Lahat G, Dhuka AR, Hallevi H, Xiao L, Zou C, Smith KD, Phung TL, Pollock RE, Benjamin R, Hunt KK, Lazar AJ, Lev D. Angiosarcoma: clinical and molecular insights. Annals of Surgery 2010; 251(6): 1098-1106.

Mattiuzzi GN, Cortes JE, Blamble DA, Bekele BN, Xiao L, Cabanillas M, Borthakur G, O'Brien S, Kantarjian H. Daily palonosetron is superior to ondansetron in the prevention of delayed chemotherapy-induced nausea and vomiting in patients with acute myelogenous leukemia. Cancer 2010; 116(24): 5659-5666.

Moroney J, Wheler J, Hong D, Naing A, Falchook G, Bodurka D, Coleman R, Lu K, Xiao L, Kurzrock R. Phase I clinical trials in 85 patients with gynecologic cancer: the M. D. Anderson Cancer Center experience. Gynecologic Oncology 2010; 117(3): 467-472.

Murthy SB, Patnana SV, Xiao L, Rohren E, Hofstetter WL, Swisher SG, Liao Z, Lee JH, Bhutani MS, Macapinlac HA, Wang X, Ajani JA. The standardized uptake value of 18-fluorodeoxyglucose positron emission tomography after chemoradiation and clinical outcome in patients with localized gastroesophageal carcinoma. Oncology 2010; 78(5-6): 316-322.

Nicoloso MS, Sun H, Spizzo R, Kim H, Wickramasinghe P, Shimizu M, Wojcik SE, Ferdin J, Kunej T, Xiao L, Manoukian S, Secreto G, Ravagnani F, Wang X, Radice P, Croce CM, Davuluri RV, Calin GA. Single-nucleotide polymorphisms inside microRNA target sites influence tumor susceptibility. Cancer Research 2010; 70(7): 2789-2798.

Patnana SV, Murthy SB, Xiao L, Rohren E, Hofstetter WL, Swisher SG, Liao Z, Lee JH, Bhutani MS, Macapinlac HA, Wang X, Ajani JA. Critical role of surgery in patients with gastroesophageal carcinoma with a poor prognosis after chemoradiation as defined by positron emission tomography. Cancer 2010; 116(19): 4487-4494.

Rossi S, Shimizu M, Barbarotto E, Nicoloso MS, Dimitri F, Sampath D, Fabbri M, Lerner S, Barron LL, Rassenti LZ, Jiang L, Xiao L, Hu J, Secchiero P, Zauli G, Volinia S, Negrini M, Wierda W, Kipps TJ, Plunkett W, Coombes KR, Abruzzo LV, Keating MJ, Calin GA. microRNA fingerprinting of CLL patients with chromosome 17p deletion identify a miR-21 score that stratifies early survival. Blood 2010; 116(6): 945-952.

Shureiqi I, Chen D, Day RS, Zuo X, Hochman FL, Ross WA, Cole RA, Moy O, Morris JS, Xiao L, Newman RA, Yang P, Lippman SM. Profiling lipoxygenase metabolism in specific steps of colorectal tumorigenesis. Cancer Prevention Research (Philadelphia) 2010; 3(7): 829-838.

2009

Sonpavde G, Aparicio AM, Zhan F, North B, Delaune R, Garbo LE, Rousey SR, Weinstein RE, Xiao L, Boehm KA, Asmar L, Fleming MT, Galsky MD, Berry WR, Von Hoff DD. Azacitidine favorably modulates PSA kinetics correlating with plasma DNA LINE-1 hypomethylation in men with chemonaïve castration-resistant prostate cancer. Urologic Oncology 2009;  29(6): 682-689.

Javeri H, Xiao L, Rohren E, Lee JH, Liao Z, Hofstetter W, Maru D, Bhutani MS, Swisher SG, Macapinlac H, Wang X, Ajani JA. The higher the decrease in the standardized uptake value of positron emission tomography after chemoradiation, the better the survival of patients with gastroesophageal adenocarcinoma. Cancer 2009; 115(22): 5184-5192.

Lee JH, Stewart J, Ross WA, Anandasabapathy S, Xiao L, Staerkel G. Blinded prospective comparison of the performance of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of the pancreas and peri-pancreatic lesions. Digestive Diseases and Sciences 2009; 54(10): 2274-2281.

Salahudeen AK, Kumar V, Madan N, Xiao L, Lahoti A, Samuels J, Nates J, Price K. Sustained low efficiency dialysis in the continuous mode (C-SLED): dialysis efficacy, clinical outcomes, and survival predictors in critically ill cancer patients. Clinical Journal of the American Society of Nephrology 2009; 4(8): 1338-1346.

Ye D, Garcia-Manero G, Kantarjian HM, Xiao L, Vadhan-Raj S, Fernandez MH, Nguyen MH, Medeiros LJ, Bueso-Ramos CE. Analysis of Aurora kinase A expression in CD34(+) blast cells isolated from patients with myelodysplastic syndromes and acute myeloid leukemia. Journal of Hematopathology 2009; 2(1): 2-8.

Chang B, Liu G, Xue F, Rosen DG, Xiao L, Wang X, Liu J. ALDH1 expression correlates with favorable prognosis in ovarian cancers. Modern Pathology 2009; 22(6): 817-823.

Cheon DJ, Wang Y, Deng JM, Lu Z, Xiao L, Chen CM, Bast RC, Behringer RR. CA125/MUC16 is dispensable for mouse development and reproduction. PLoS One. 2009; 4(3): e4675. 

Javeri H, Xiao L, Rohren E, Komaki R, Hofstetter W, Lee JH, Maru D, Bhutani MS, Swisher SG, Wang X, Ajani JA. Influence of the baseline 18F-fluoro-2-deoxy-D-glucose positron emission tomography results on survival and pathologic response in patients with gastroesophageal cancer undergoing chemoradiation. Cancer 2009; 115(3): 624-630.

Yang H, Kadia T, Xiao L, Bueso-Ramos CE, Hoshino K, Thomas DA, O'Brien S, Jabbour E, Pierce S, Rosner GL, Kantarjian HM, Garcia-Manero G. Residual DNA methylation at remission is prognostic in adult Philadelphia chromosome-negative acute lymphocytic leukemia. Blood 2009; 113(9): 1892-1898.  

Anaya DA, Lahat G, Wang X, Xiao L, Tuvin D, Pisters PW, Lev DC, Pollock RE. Establishing prognosis in retroperitoneal sarcoma: a new histology-based paradigm. Annals of Surgical Oncology 2009; 16(3): 667-675.

2008 and earlier

Harris LD, De La Cerda J, Tuziak T, Rosen D, Xiao L, Shen Y, Sabichi AL, Czerniak B, Grossman HB. Analysis of the expression of biomarkers in urinary bladder cancer using a tissue microarray. Molecular Carcinogenesis 2008; 47(9): 678-685.

Chamilos G, Lewis RE, Hu J, Xiao L, Zal T, Gilliet M, Halder G, Kontoyiannis DP. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proceedings of the National Academy of Sciences of the USA 2008; 105(27): 9367-9372.

Miyazaki K, Yamaguchi M, Suguro M, Choi W, Ji Y, Xiao L, Zhang W, Ogawa S, Katayama N, Shiku H, Kobayashi T. Gene expression profiling of diffuse large B-cell lymphoma supervised by CD21 expression. British Journal of Haematology 2008; 142(4): 562-70.

Zhang L, Lee JJ, Tang H, Fan YH, Xiao L, Ren H, Kurie J, Morice RC, Hong WK, Mao L. Impact of smoking cessation on global gene expression in the bronchial epithelium of chronic smokers. Cancer Prevention Research (Philadelphia) 2008; 1(2): 112-118.

Weston BR, Ross WA, Wolff RA, Evans D, Lee JE, Wang X, Xiao LC, Lee JH. Rate of bilirubin regression after stenting in malignant biliary obstruction for the initiation of chemotherapy: how soon should we repeat endoscopic retrograde cholangiopancreatography? Cancer 2008; 112(11): 2417-2423.

Zhu R, Ji Y, Xiao L, Matin A. Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain. Mammalian Genome 2007; 18(8): 584-595.

Lee JH, Stewart J, Ananda S, Thirumurthi S, Ross WA, Xiao L, Staerkel GA. Comparison of performance of 22 gauge and 25 gauge needles in endoscopic ultrasound (EUS) guided fine needle aspiration (FNA). Gastrointestinal Endoscopy  2007; 65(5): AB309.

Konoplev S, Rassidakis GZ, Estey E, Kantarjian H, Liakou CI, Huang X, Xiao L, Andreeff M, Konopleva M, Medeiros LJ. Overexpression of CXCR4 predicts adverse overall and event-free survival in patients with unmutated FLT3 acute myeloid leukemia with normal karyotype. Cancer 2007; 109(6): 1152-1156.

Burjonroppa SC, Tong AT, Xiao L, Johnson MM, Yusuf SW, Lenihan DJ. Cancer patients with markedly elevated B-type natriuretic peptide may not have volume overload. American Journal of Clinical Oncology 2007; 30(3): 287-293.

Han X, Garcia-Manero G, McDonnell TJ, Lozano G, Medeiros LJ, Xiao L, Rosner G, Nguyen M, Fernandez M, Valentin-Vega YA, Barboza J, Jones DM, Rassidakis GZ, Kantarjian HM, Bueso-Ramos CE. HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target. Modern Pathology 2007; 20(1): 54-62.

Garcia-Manero G, Kantarjian H, Sanchez-Gonzalez B, Yang H, Rosner G, Verstoysek S, Rytting M, Wierda WG, Rayandi F, Koller C, Xiao L, Faderl S, Estrov Z, Cortes J, O’Brien S, Estey E, Bueso-Ramos C, Fiorentino J, Jabbour E, Issa J-P. Phase 1/2 study of the combination of 5-aza-2’–deoxycytidine with valproic acid in patients with leukemia. Blood 2006; 108(10): 3271-3279.

Xu H, Cheepala S, McCauley E, Coombes K, Xiao L, Fischer SM, Clifford JL. Chemoprevention of skin carcinogenesis by phenylretinamides: retinoid receptor-independent tumor suppression. Clinical Cancer Research 2006; 12(3 Part 1): 969-979.
 
Tsao AS, Tang XM, Sabloff B, Xiao L, Shigematsu H, Roth J, Spitz M, Hong WK, Gazdar A, Wistuba I. Clinicopathologic characteristics of the EGFR gene mutation in non-small cell lung cancer. Journal of Thoracic Oncology 2006; 1(3): 231-239.

Xiao L, Zhao L, Li T, Hartle DK, Aruoma OI, Taylor EW. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. BioFactors 2006; 27(1-4):157-165.

Shen L, Kondo Y, Rosner G, Xiao L, Hernandez NS, Vilathong J, Houlihan PS, Krouse R, Prasad AR, Einsphar JG, Buckmeier J, Alberts DS, Hamilton SR, Issa JP. MGMT promoter methylation and field defect in sporadic colorestal cancer. Journal of the National Cancer Institute 2005; 97(8):1330-1338.

Koomen J, Li D, Xiao L, Liu T, Coomes K, Abbruzzese J, Kobayashi R. Direct tandem mass spectrometry reveals limitations in protein profiling experiments for plasma biomarker discovery. Journal of Proteome Research 2005; 4(3): 972-981.

Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by up-regulation of mitochondrial cell death protein, BNIP3. Oncogene 24(6): 980-991.

Koomen JM, Shih LN, Coombes KR, Li D, Xiao L, Fidler IJ, Abbruzzese JL, Kobayashi R. Plasma protein profiling for diagnosis of pancreatic cancer reveals the presence of host response proteins. Clinical Cancer Research 2005; 11(3):1110-1118.

Kuerer HM, Coombes KR, Chen JN, Xiao L, Clarke C, Fritsche H, Krishnamurthy S, Marcy S, Hung MC, Hunt KK. Association between ductal fluid proteomic expression profiles and the presence of lymph node metastases. Surgery 2004; 136(5):1061-1069.

Pawlik TM, Fritsche H, Coombes KR, Xiao L, Krishnamurthy S, Hunt KK, Pusztai L, Chen JN, Clarke CH, Arun B, Hung MC, Kuerer HM. Significant differences in ductal fluid protein expression in healthy women versus those with breast cancer identified by time-of-flight mass spectrometry. Breast Cancer Research and Treatment 2005; 89: 149-157.

Coombes K, Fritshe HA, Clarke C, Chen JN, Baggerly KA, Morris JS, Xiao L, Hung MC, Kuerer HM. Quality control and peakfinding for proteomics data collected using surface enhanced laser desorption and ionization. Clinical Chemistry 2003; 49(10): 1615-1623.

Baggerly KA, Morris JS, Wang J, Gold D, Xiao L, Coombes KR. A comprehensive approach to the analysis of matrix-assisted laser desorption/ionization time of flight proteomics spectra from serum samples. Proteomics 2003; 3: 1667-1672.

Giles FJ, Kantarjian HM, Cortes JE, Garcia-Manero G, Verstovsek S, Fadel S, Thomas D, Ferrajoli A, O’Brien S, Wather J, Xiao L, Berry D, Estey EH. Adaptive randomization study of idarubicin and cytarabine versus troxacitabine and cytarabine versus troxacitabine and idarubine in untreated patients 50 years or older with adverse karyotype acute myeloid leukemia. Journal of Clinical Oncology 2003; 21(9): 1722-1727.

Blackmon BJ, Daily TA, Xiao L, Dailey H. Characterization of human and mouse Heme binding protein. Archives of Biochemistry and Biophysics 2002; 407: 196 -201.

Huang C, Zhang L, Zhang J, Xiao L, Wu QJ, Chen D, Li JK. Purification and characterization of white spot synfrome virus (WSSV) produced in an alternate host: crafish, Cambarus clarkii. Virus Research 2001; 76(2): 115-125.

Shi Z, Xiao L, et al. Immunological detection of two kinds of viruses from Penaeus chinesis. Virological Sinica 1996; 11(4): 365.

Hein A, Czub S, Xiao L, Schwender S, Dorries R, Czub M. Effects of adoptive immune transfer on murine leukemia virus-infection of rats. Virology 1995; 211: 408-417.

Xiao L, Shi Z, et al. Isolation and purification of spherical virus from Penaeus chinesis and analysis of its nucleic acid and protein. Virological  Sinica 1995; 10(4).

Zhang J, Xiao L, Zhang L. Infection and morphogensis of noninclusion body baculovirus from Penaeus orientalis K. in vivo. Virological Sinica 1994; 9(4):362-366.

Zhang J, Chen D, Xiao L, Zhang L. Infection and morphorgensis of non-inclusion body baculovirus from Penaeus orientialis Kishinoye in vivo. Virological Sinica 1994; 12(4).

Xiao L, Zou T, Zhang L. The SEM observation on Vasa mesoca substructure of Bombox mori. Acta Scientarium Naturalium Universitatis Normalis Hunanensis 1993; 16(suppl): 36-37.

 

Updated March 7, 2013


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