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Jiexin Zhang, M.S.

Principal Statistical Analyst

Degrees

  • M.S. in Computer Science, Rice University, Houston TX
  • M.S. in Biochemistry, Case Western Reserve University, Cleveland OH

Areas of Interest

  • Gene network analysis
  • Microarray/proteomics data analysis
  • DNA/protein sequence analysis
  • Bioinformatics database management and mining
  • Programming: S-Plus, R, Matlab, Perl, C/C++

Publications

Tzelepi V, Zhang J, Lu JF, Kleb B, Wu G, Wan X, Hoang A, Efstathiou E, Sircar K, Navone NM, Troncoso P, Liang S, Logothetis CJ, Maity SN, Aparicio AM. Modeling a lethal prostate cancer variant with small-cell carcinoma features. Clinical Cancer Research 2012; 18(3):666-677.

Iwamoto T, Booser D, Valero V, Murray JL, Koenig K, Esteva FJ, Ueno NT, Zhang J, Shi W, Qi Y, Matsuoka J, Yang EJ, Hortobagyi GN, Hatzis C, Symmans WF, Pusztai L. Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry. Journal of Clinical Oncology 2012; 30(7):729-734.

Agrawal N, Frederick MJ, Pickering CR, Bettegowda C, Chang K, Li RJ, Fakhry C, Xie TX, Zhang J, Wang J, Zhang N, El-Naggar AK, Jasser SA, Weinstein JN, Treviño L, Drummond JA, Muzny DM, Wu Y, Wood LD, Hruban RH, Westra WH, Koch WM, Califano JA, Gibbs RA, Sidransky D, Vogelstein B, Velculescu VE, Papadopoulos N, Wheeler DA, Kinzler KW, Myers JN. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011; 333(6046):1154-1157.

Duggan JM, You D, Cleaver JO, Larson DT, Garza RJ, Guzmán Pruneda FA, Tuvim MJ, Zhang J, Dickey BF, Evans SE. Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. Journal of Immunology 2011; 186(10):5916-5926.

Waterland RA, Kellermayer R, Laritsky E, Rayco-Solon P, Harris RA, Travisano M, Zhang W, Torskaya MS, Zhang J, Shen L, Manary MJ, Prentice AM. Season of conception in rural gambia affects DNA methylation at putative human metastable epialleles. PLoS Genetics 2010; 6(12):e1001252.

Evans SE, Tuvim MJ, Zhang J, Larson DT, García CD, Martinez-Pro S, Coombes KR, Dickey BF. Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia. Respiratory Research 2010; 11:101.

Oh CD, Maity SN, Lu JF, Zhang J, Liang S, Coustry F, de Crombrugghe B, Yasuda H. Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One 2010; 5(4):e10113.

Maegawa S, Hinkal G, Kim HS, Shen L, Zhang L, Zhang J, Zhang N, Liang S, Donehower LA, Issa JP. Widespread and tissue specific age-related DNA methylation changes in mice. Genome Research 2010; 20(3):332-340.

Waterland RA, Kellermayer R, Rached MT, Tatevian N, Gomes MV, Zhang J, Zhang L, Chakravarty A, Zhu W, Laritsky E, Zhang W, Wang X, Shen L. Epigenomic profiling indicates a role for DNA methylation in early postnatal liver development. Human Molecular Genetics 2009;18(16):3026-3038.

Dong J, Akcakanat A, Stivers DN, Zhang J, Kim D, Meric-Bernstam F. RNA-binding specificity of Y-box protein 1. RNA Biology 2009; 6(1):59-64.

Kiyama T, Zhang J, Liang S, Liang S, Klein WH. Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus. Marine Genomics 2009; 2(2):85-98.

Gao W, Kondo Y, Shen L, Shimizu Y, Sano T, Yamao K, Natsume A, Goto Y, Ito M, Murakami H, Osada H, Zhang J, Issa JP, Sekido Y. Variable DNA methylation patterns associated with progression of disease in hepatocellular carcinomas. Carcinogenesis 2008; 29(10):1901-1910.

Zhang J, Ji Y, Zhang L. Extracting three-way gene interactions from microarray data. Bioinformatics 2007; 23(21): 2903-2909.

Shen L, Kondo Y, Guo Y, Zhang J, Zhang L, Ahmed S, Shu J, Chen X, Waterland RA, Issa JP. Genome-wide profiling of DNA methylation reveals a class of normally methylated CpG island promoters. PLoS Genetics 2007; 3(10):e181.

Mori–Akiyama Y, van den Born M, van Es JH, Hamilton SR, Adams HP, Zhang J, Clevers H, de Crombrugghe B. SOX9 is required for the differentiation of paneth cells in the intestinal epithelium. Gastroenterology 2007; 133(2):539-546.

Zhang J, Zhang L, Coombes K. Gene sequence signatures revealed by mining the UniGene affiliation network. Bioinformatics 2006; 22(4):385-391.

Ji Y, Coombes K, Zhang J, Wen S, Mitchell J, Pusztai L, Symmans WF, Wang J. RefSeq refinements of UniGene-based gene matching improve the correlation of expression measurements between two microarray platforms. Applied Bioinformatics 2006; 5(2):89-98.

Chirieac LR, Trent JC, Steinert DM, Choi H, Yang Y, Zhang J, Patel SR, Benjamin RS, Raymond AK. Correlation of immunophenotype with progression-free survival in patients with gastrointestinal stromal tumors treated with imatinib mesylate. Cancer 2006; 107(9): 2237-2244.

Gerken TA, Zhang J, Levine J, Elhammer A. Mucin core O-glycosylation is modulated by neighboring residue glycosylation status. Kinetic modeling of the site-specific glycosylation of the apo-porcine submacillary mucin tandem repeat by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases T1 and T2. Journal of Biological Chemistry 2002; 277(51): 49850-49862.

Gerken TA, Gilmore M, Zhang J. Determination of the site-specific oligosaccharide distribution of the O-glycans attached to the porcine submaxillary mucin tandem repeat. Further evidence for the modulation of O-glycans side chain structures by peptide sequence. Journal of Biological Chemistry 2002; 277(10):7736-7751.

Zhang X, Zhang J, Lu G, Chen R, Jia H. Cloning of chicken transcription enhancer factor-1 related gene and its expression during development. Journal of Peking University (Health Science) 2001; 33(1):58-61

Awards

  • Performance Reward: In Recognition of Exceptional Performance Through Productivity. The University of Texas MD Anderson Cancer Center. August, 2007.
  • Performance Reward: In Recognition of Exceptional Performance Through Outstanding Contributions. The University of Texas MD Anderson Cancer Center. March, 2005.
  • Best Presentation Award: Rocky Mountain Regional Bioinformatics Conference. December, 2005.

 

Updated March 8, 2013


© 2014 The University of Texas MD Anderson Cancer Center