Hui Yao, Ph.D.

Principal Statistical Analyst

Degrees

Ph.D. in Structural and Computational Biology, Baylor College of Medicine, Houston, TX
M.S. in Information System and Computer Science, National University of Singapore, Singapore
B.S. in Genetics, Fudan University, Shanghai, China

Areas of Interest

Integration of high-throughput technologies (Array CGH, SNP array, expression array, lysate array, etc.) to study mechanisms of cancers
Identification of biomarkers for cancer diagnosis and prognosis
Clinical bioinformatics
Survival analysis and clinical trial design
Programming in R/S+, SAS, C/C++, and Perl

Publications

Frederick MJ, VanMeter AJ, Gadhikar MA, Henderson YC, Yao H, Pickering CC, Williams MD, El-Naggar AK, Sandulache V, Tarco E, Myers JN, Clayman GL, Liotta LA, Petricoin EF 3rd, Calvert VS, Fodale V, Wang J, Weber RS. Phosphoproteomic analysis of signaling pathways in head and neck squamous cell carcinoma patient samples. Am. J. Pathol. 2011; 178(2):548-71.

Zuo Z, Jones D, Yao H, Thomas DA, O'Brien S, Ravandi F, Kantarjian HM, Abruzzo LV, Medeiros LJ, Chen SS, Luthra R. A pathway-based gene signature correlated with therapeutic response in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia. Mod. Pathol. 2010; 23(11):1524-34.

Chandra P, Luthra R, Zuo Z, Yao H, Ravandi F, Reddy N, Garcia-Manero G, Kantarjian H, Jones D. Acute myeloid leukemia with t(9;11)(p21-22;q23): common properties of dysregulated ras pathway signaling and genomic progression characterize de novo and therapy-related cases. Am. J. Clin. Pathol. 2010; 133(5):686-93.

Earle J, Luthra R, Romans A, Abraham R, Ensor J, Yao H, Hamilton SR. Association of microRNA expression with microsatellite instability status in colorectal adenocarcinoma. J. Mol. Diagn. 2010; 12(4):433-40.

Baameur F, Morgan DH, Yao H, Tran TM, Hammitt RA, Sabui S, McMurray JS, Lichtarge O, Clark RB. Role for the RH domain of GRK5 and 6 in β2-adrenergic receptor and rhodopsin phosphorylation. Mol. Pharmacol. 2010; 77(3):405-15.

Jones D, Yao H, Romans A, Dando C, Pierce S, Borthakur G, Hamilton A, Bueso-Ramos C, Ravandi F, Garcia-Manero G, Kantarjian H. Modeling interactions between leukemia-specific chromosomal changes, somatic mutations, and gene expression patterns during progression of core-binding factor leukemias. Genes Chromosomes Cancer. 2010; 49(2):182-91.

Zhang W, Cortes J, Yao H, Zhang L, Reedy N, Jabbour E, Kantarjian HM, Jones D. Predictors of primary imatinib resistance in chronic myeloid leukemia are distinct from those in secondary imatinib resistance. J. Clin. Oncol. 2009; 27(22):3642-9.

Maru DM, Singh RR, Hannah C, Albarracin CT, Li YX, Abraham R, Romans AM, Yao H, Luthra MG, Anandasabapathy S, Swisher SG, Hofstetter WL, Rashid A, Luthra R. MicroRNA-196a is a potential marker of progression during Barrett's metaplasia-dysplasia-invasive adenocarcinoma sequence in esophagus. Am. J. Pathol. 2009; 174(5):1940-8.

Tian Z, Palmer N, Schmid P, Yao H, Galdzichi M, Berger B, Wu E, Kohane IS. A practical platform for global gene expression profiling analysis based on bead array and peripheral whole blood samples. PLoS ONE 2009; 4(4):e5157.

Sargent R, Jones D, Lynne VA, Yao H, Bonderover J, Cisneros M, Wierda WG, Keating MJ, Luthra R. Customized oligonucleotide array based comparative genomic hybridization as a clinical assay for genomic profiling of chronic lymphocytic leukemia. J. Mol. Diagn. 2009; 11(1):25-34.

Morrow EM, Yoo SY, Flavell SW, Kim TK, Lin Y, Hill RS, Mukaddes NM, Balkhy S, Gascon G, Hashmi A, Al-Saad S, Ware J, Joseph RM, Greenblatt R, Gleason D, Ertelt JA, Apsek A, Bodell A, Partlow JN, Barry B, Yao H, Markianos K, Ferland RJ, Greenberg ME, Walsh CA. Identifying autism loci and genes by tracing recent shared ancestry. Science. 2008; 321(5886):218-23.

Yao H, Mihalek I, Lichtarge O. Rank information: a structure-independent measure of evolutionary trace analysis improves identification of protein functional sites. Proteins. 2006; 65(1):111-23.

Yao H, Kristensen DM, Mihalek I, Sowa ME, Shaw C, Kimmel M, Kavraki L, Lichtarge O. An accurate, sensitive, and scalable method to identify functional sites in protein structures. J. Mol. Biol. 2003; 326:255-261.

Lichtarge O, Yao H, Kristensen DM, Madabushi S, Mihalek I. Accurate and scalable identification of functional sites by evolutionary tracing. J. Struct. Func. Gen. 2003; 4(2-3):159-166.

Mihalek I, Res O, Yao H, Lichtarge O. Combining inference from evolution and geometric probability in protein structure evaluation. J. Mol. Biol. 2003; 331:263-279.

Madabushi S, Yao H, Marsh M, Kristensen DM, Philippi A, Sowa ME, Lichtarge O. Structural clusters of evolutionary trace residues are statistically significant and common in proteins. J. Mol. Biol. 2002; 316(1):139-54.

Du G, Pan M, Zhou Y, Chen J, Yao H, Yuan J, Qiang B. Cloning of human and mouse GRY-RBP cDNA. Chin. Sci. Bull. 2000; 45(4):343-50.

Pan M, Yuan J, Du G, Zhou Y, Yao H, Qiang B. Isolation and expression pattern analysis of novel ETSs from human fetal brain. Chin. Sci. Bull. 1998; 43(21):1815-9.

^{Updated June 29, 2011}