SUMO 2008 Past Programs
Conference Program 2008
Thursday, February 7, 2008
7:00 a.m. Registration and Continental Breakfast
7:55 a.m. Welcome
Raymond DuBois
The University of Texas MD Anderson Cancer Center, Houston, TX
8:00-9:30 a.m. Session I
Moderator: Edward T. H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX
Overview
Edward T. H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX
Crosstalk between SUMOylation and ubiquitination
Tony Hunter
Salk Institute for Biological Studies, La Jolla, CA
Poly-SUMO chains as a signal for protein degradation
Ronald T. Hay
University of Dundee, Dundee, Scotland
9:30-10:05 a.m. Break
10:05 a.m.-12:10 p.m. Session II
Moderator: Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel
Regulation of ubiquitin-dependent and ubiquitin-independent turnover of transcriptional coregulators
Bert O'Malley
Baylor College of Medicine, Houston, TX
Transcriptional control and the ubiquitin-proteasome system
William P. Tansey
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY
Regulation of transcription factor activity by SUMO
Grace Gill
Tufts University School of Medicine, Boston, MA
Translating histone crosstalk between H2B monoubiquitination and H3 methylation by compass
Ali Shilatifard
Stowers Institute for Medical Research, Kansas City, MO
The SUMO signaling in the regulation of epigenome and cell functions: Involvement of SUMO-SIM interaction in MBD1 and MCAF1 mediated heterochromatin formation
Hisato Saitoh
Kumamoto University, Kumamoto, Japan
12:10-1:30 p.m. Lunch
Informal round table discussion
1:30-3:35 p.m. Session III
Moderator: Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel
The ubiquitin ligase Siah in tumorigenesis and metastasis
Ze'ev Ronai
The Burnham Institute, La Jolla, CA
Regulation of endosome fusion by VHL tumour suppressor protein
Michael Ohh
University of Toronto, Toronto, Canada
SUMOylation in TNF signaling
Wang Min
Yale University, New Haven, CT
New insights into the role of the PHD domain as an E3 ligase for SUMOylation and gene silencing
Frank J. Rauscher, III
The Wistar Institute, Philadelphia, PA
Autophagy in cell growth control and tumor suppression
Beth Levine
The University of Texas Southwestern Medical Center, Dallas, TX
Yop and Vop play ping-pong
Kim Orth
The University of Texas Southwestern Medical Center, Dallas, TX
3:35-4:15 p.m. Break
4:15-6:15 Session IV
Friday, February 8, 2008
7:00 a.m. Registration and Continental Breakfast
8:00-9:40 Session V
Moderator: Ronald T. Hay
University of Dundee, Dundee, Scotland
Mechanism and consequences for paralog specific SUMOylation of ubiquitin-specific protease 25
Frauke Melchior
Georg-August-Universität Göttingen, Göttingen, Germany
SUMO-2/3 modification of kinetochore-associated proteins is essential for chromosome segregation
Michael Matunis
Johns Hopkins University, Baltimore, MD
Vertebrate SUMO protease SENP3 and SENP5 play an important role in ribosome biogenesis
Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, MD
Model approaches for the study of SUMO E2 and E3 function
Jacob Seeler and Anne Dejean
Institut Pasteur, Paris, France
9:40-10:00 a.m. Break
10:00-11:40 a.m. Session VI
Moderator: George DeMartino
The University of Texas Southwestern Medical Center, Dallas, TX
Control of cell survival and proliferation by SCF ubiquitin ligase complexes
Michele Pagano
NYU Cancer Institute, New York University School of Medicine, New York, NY
DNA damage checkpoint control by Cullin-RING ubiquitin ligases
Jianping Jin
The University of Texas Medical School at Houston, Houston, TX
The Cullin-ROC family of E3 ubiquitin ligases
Yue Xiong
University of North Carolina at Chapel Hill, Chapel Hill, NC
Regulation of PCNA modifications in DNA replication and repair
Helle Ulrich
London Research Institute, London, England
Set up for Institutional Grand Rounds
12:00-1:00 p.m. Lunch Session VII
Advances in Oncology Institutional Grand Rounds
Introduction
John Mendelsohn
The University of Texas MD Anderson Cancer Center, Houston, TX
Mode of regulation of APC/C ubiquitin-protein ligase by the mitotic checkpoint system
Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel
Novel modes of ubiquitination and their possible biological functions
Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel
1: 00-1:15 p.m. Group Photo
1:15-2:55 p.m. Session VIII
Moderator: Leroy Liu
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ
Mechanisms of IKK activation by TRAF-mediated polyubiquitination
James Chen
The University of Texas Southwestern Medical Center, Dallas, TX
Regulation of immune tolerance and function by protein ubiquitination
Chen Dong
The University of Texas MD Anderson Cancer Center, Houston, TX
Roles of the SUMO pathway in NF-қB signaling
Shigeki Miyamoto
University of Wisconsin-Madison, Madison, WI
A role for RSUME in the SUMOylation pathway
Eduardo Arzt
Universidad de Buenos Aires, Buenos Aires, Argentina
2:55-3:15 p.m. Break
3:15-4:30 p.m. Session IX
Moderator: Yue Xiong
University of North Carolina at Chapel Hill, Chapel Hill, NC
Structural insights into NEDD8 activation
Brenda Schulman
St. Jude Children's Research Hospital, Memphis, TN
Activity of MLN4924, a small molecule inhibitor of NEDD8-activating enzyme NAE in preclinical models of cancer
Teresa Soucy
Millennium Pharmaceuticals Inc., Cambridge, MA
ISG15 in tumorigenesis and drug sensitivity
Leroy Liu
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ
4:30-4:45 p.m. Break
4:45-6:45 p.m. Session X
Short Walk to Poster Session and Dinner
7:00-8:00 p.m. Dinner
7:30-10:00 p.m. Session XI
Poster Session
Even side: 7:30-8:45 p.m.
Odd side: 8:45-10:00 p.m.
Saturday, February 9, 2008
7:00 a.m. Continental Breakfast
8:00-10:05 Session XII
Moderator: Hsing-Jien Kung
University of California Davis Cancer Center, Sacramento, CA
SUMO-specific protease 1 is essential for the stability of HIF1α
Jinke Cheng
The University of Texas MD Anderson Cancer Center, Houston, TX
Role of PML/RARA SUMOylation in transformation and the molecular basis of arsenic trioxide action in APL
Hugues de Thé
University of Paris, Paris, France
Daxx: a SUMO wrestler in transcription and cancer
Hsiu-Ming Shih
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
Ubiquitin ligases in the heart
Jonathan Schisler and Cam Patterson
University of North Carolina at Chapel Hill, Chapel Hill, NC
GSK3β and Erk-mediated protein degradation and their role in tumorigenesis
Mien-Chie Hung
The University of Texas MD Anderson Cancer Center, Houston, TX
10:05-10:25 a.m. Break
10:25 a.m.-12:30 p.m. Session XIII
Moderator: Michael Matunis
Johns Hopkins University, Baltimore, MD
E2 and E3 specificity in the SUMO pathway
Christopher D. Lima
Sloan-Kettering Institute, New York, NY
DeSUMOylating enzymes and clan CE
Guy Salvesen
The Burnham Institute, La Jolla, CA
Distribution and paralog specificity of mammalian deSUMOylating enzymes
Keith Wilkinson
Emory University, Atlanta, GA
Targeting ubiquitin networks
Ivan Dikic
Goethe University School of Medicine, Frankfurt, Germany
Gankyrin, liver oncoprotein and regulator of pRb, p53 and NFқB
R John Mayer
University of Nottingham Medical School, Nottingham, United Kingdom
12:30-12:55 p.m. Break/Lunch
Pick up box lunch
12:55-2:35 p.m. Session XIV
Moderator: R John Mayer
University of Nottingham Medical School, Nottingham, United Kingdom
Function and regulation of the proteasome
George N. DeMartino
The University of Texas Southwestern Medical Center, Dallas, TX
CYLD: a deubiquitinating enzyme regulating diverse biological functions
Shao-Cong Sun
The University of Texas MD Anderson Cancer Center, Houston, TX
Protection of AGC kinases Akt and PKC by the SIN1-Rictor-mTOR complex from ubiquitin-mediated proteasomal degradation
Bing Su
Yale University School of Medicine, New Haven, CT
Towards ubiquitination – a new twist in Mdm2-p53 dogma
Yanping Zhang
University of North Carolina at Chapel Hill, Chapel Hill, NC
Closing Comments and Adjourn
Edward T. H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX