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SUMO 2006 Past Program

Conference Program 2006

Thursday, February 9, 2006

7:00 a.m. Registration and Continental Breakfast

7:55  Welcome
Edward T. H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX

8:00-9:55 Session I 
Moderator William Tansey
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Control of the cell cycle by SCF ubiquitin ligase complexes
Michele Pagano
New York University School of Medicine and NYU Cancer Institute, New York, NY
  
The cullin-ROC family E3 ligases 
Yue Xiong
University of North Carolina at Chapel Hill, Chapel Hill, NC

Novel insights into the regulation of hypoxia response
Ze’ev Ronai 
The Burnham Institute, La Jolla, CA
  
Mechanism of regulation of 26S proteasome function by ATP
George N. DeMartino
The University of Texas Southwestern Medical Center, Dallas, TX

The COP9 signalosome targets the tumor suppressors p53 and p27 for degradation by the ubiquitin system
Wolfgang Dubiel
Charité, Universitätsmedizin Berlin, Berlin, Germany

9:55-10:30 Break

10:30-12:05 pm Session II 
Moderator Hsing-Jien Kung
University of California Davis Cancer Center, Davis, CA

Transcriptional control and the ubiquitin system
William Tansey
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Role of ubiquitin-like proteins in gene expression
Ronald T. Hay
University of St. Andrews, St. Andrews, Scotland
  
Regulation of the dual function transcription factor Sp3 by SUMO 
Grace Gill
Harvard Medical School, Boston, MA

The molecular mechanism of histone H2B monoubiquitination by Rad6/Bre1: Implications in the regulation of gene expression
Ali Shilatifard
St. Louis University School of Medicine, St. Louis, MO

An emerging role for SUMO modification in the regulation of polyadenylation
Vasupradha Vethantham
Columbia University, New York, NY

12:05-1:00 pm Lunch  
Informal round table discussion

1:00-2:20 Session III 
Moderator Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel

Ubiquitin signaling in the NF-kappaB pathway
James Chen
The University of Texas Southwestern Medical Center, Dallas, TX

Regulation of FOXO transcription factors via atypical ubiquitin linkages 
Cam Patterson
The University of North Carolina at Chapel Hill, Chapel Hill, NC

Site-specific auto-ubiquitination of TRAF6 through Lys63 linkages connects RANK signaling to osteoclast differentiation
Bryant G. Darnay
The University of Texas MD Anderson Cancer Center, Houston, TX

Structural mechanisms for intracellular sorting of ubiquitylated proteins
Gali Prag
National Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, MD

2:20-2:50  Break

2:50-4:00 Session IV 
Moderator Leroy Liu
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ

Lack of ISF15 deconjugating enzyme Ubp43, but not the increase of protein ISGylation, is involved in hypersensitive responses to Type I interferon
Dong-Er Zhang
The Scripps Research Institute, La Jolla, CA

Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways  
Robert Krug
The University of Texas at Austin, Austin, TX
 
Re-examination of the role of ubiquitin-like modifier ISG15 in the phenotype of UBP43(USP18) deficient mice
Klaus-Peter Knobeloch
FMP Research Institute of Molecular Pharmacology, Berlin, Germany

The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10
Marcus Groettrup
University of Konstanz, Konstanz, Germany

4:00-4:30 Break

4:30-6:15 Session V 
Breakout session

6:15-7:15 Wine, Beer and Hors d’Oeuvres 

Friday, February 10, 2006

7:00 a.m. Continental Breakfast

8:00-9:45 Session VI 
Moderator Mary Dasso
National Institute of Child Health and Human Development,Bethesda, MD

The small ubiquitin-related modifier (SUMO): A big regulator of cell cycle progression
Michael Matunis
Johns Hopkins University, Baltimore, MD

Insights into post-translational modification by SUMO  
Christopher D. Lima
Sloan-Kettering Institute, New York, NY
 
Function of Siz-dependent SUMO conjugation

Erica Johnson
Thomas Jefferson University, Philadelphia, PA

A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation
David Owerbach
Baylor College of Medicine, Houston, TX 
  
MCAF1/AM interaction with SUMO-2/3 links to heterochromatin formation in mammalian culture cells
Hisato Saitoh
Kumamoto University, Kumamoto, Japan

9:45-10:05  Break

10:05-11:35 Session VII 
Moderator Michael J. Matunis
Johns Hopkins University, Baltimore, MD

Characterization of vertebrate SUMO proteases
Mary Dasso
The National Institute of Child Health and Human Development, Bethesda, MD 

Control of chromatin recognition and gene silencing by sumoylation: E3 activity of a PHD domain mediates intramolecular sumoylation of a bromodomain
Frank J. Rauscher, III
The Wistar Institute, Philadelphia, PA

Diversity of ULP1s
Kim Orth
The University of Texas Southwestern Medical Center, Dallas, TX

The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice
Karim Nacerddine
Institut Pasteur, Paris, France

Set up for Institutional Grand Rounds

12:00-1:00 p.m. Lunch Session VIII 
Advances in Oncology Institutional Grand Rounds

Roles of the ubiquitin system in cell cycle control  
Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel
  
Role of sumoylation in cancer and development  
Edward T.H. Yeh 
The University of Texas MD Anderson Cancer Center, Houston, TX

1:15   Group Photo

1:30-3:30 Session IX 
Moderator  Christopher D. Lima
Sloan-Kettering Institute, New York, NY

Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes
Frauke Melchoir
Georg-August-Universität Göttingen, Göttingen, Germany

Cell signaling by ubiquitin and ubiquitin-like modifiers
Ivan Dikic
Goethe University School of Medicine, Frankfurt, Germany

SUMO and Kaposi's sarcoma herpesvirus replication
Hsing-Jien Kung  
University of California, Davis, Sacramento, CA
  
How Daxx wrestles with SUMO in transcriptional control and subnuclear compartmentalization
Hsiu-Ming Shih
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, R.O.C.

The polycomb-associated protein RYBP functions as both a ubiquitin and a SUMO receptor
Rachele Arrigoni
Albert Einstein College of Medicine, Bronx, NY

Distinct functional domains of Ubc9 dictate cell survival and resistance to genotoxic stress
Robert van Waardenburg 
St. Jude Children's Research Hospital, Memphis, TN

3:30-4:00 Break

4:00-6:00 Session X 

6:30-7:45 International Dinner in CPB

6:30 Hors d'Oeuvres, Wine and Beer

7:15 Dinner

7:45  Session XI
Conversation with Living Legends

Saturday, February 11, 2006

7:00 a.m. Continental Breakfast

8:00-10:15 Session XII
Moderator Ronald T. Hay
University of St. Andrews, St. Andrews, Scotland 

Insights into the specificity of ubiquitin-like protein transfer cascades
Brenda Schulman  
St. Jude Children's Research Hospital, Memphis, TN

NEDDYLATION of a breast cancer associated protein recruits a Class III histone deacetylase that represses NFkB-dependent transcription
Fei Gao
Shanghai Jiaotong University School of Medicine,Shanghai, China
  
Regulation of Cul4A by human E2-containing DET1 complex
Ning Wei
Yale University, New Haven, CT
  
F-Box-directed CULLIN-RING ubiquitin ligase assembly and regulation by the COP9/Signalosome
Dieter Wolf
Harvard University, Boston, MA

Inhibition of NAE leads to DNA re-replication, DNA damage, and cell death
Michael Milhollen
Millennium Pharmaceuticals, Inc., Cambridge, MA
  
Effects of proteasome inhibition on both tumor and host microenvironment in myeloma
Gregory R. Mundy
The University of Texas Health Science Center San Antonio, San Antonio, TX
 
Targeting the ubiquitin proteasome pathway in lymphoma: An update on emerging clinical data and mechanistic rationale
Owen A. O'Connor
Memorial Sloan Kettering Cancer Center, New York, NY

10:15-10:40 Break

10:40-12:40 Session XIII 

12:40-1:15 p.m. Lunch  

1:15-3:25 Session XIV 
Moderator  Yue Xiong
University of North Carolina at Chapel Hill, Chapel Hill, NC

The function of UPS in tumor genesis
Peter-M.  Kloetzel  
Charité, University Medicine Berlin, Berlin, Germany

Ubiquitin and ubiquitin-like proteins as determinants of tumor cell sensitivity to Topoisomerase-targeted anticancer drugs  
Leroy Liu
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ
  
Inhibiting the ubiquitin system to induce cell death in cancer
Allan Weissman
National Institutes of Health, Bethesda, MD

Control of the ARF-MDM2-p53 pathway by ubiquitin-mediated proteolysis
Yanping Zhang
University of North Carolina at Chapel Hill, Chapel Hill, NC

Thiopurine S-methyltransferase (TPMT) pharmacogenomics:  the role of protein degradation and aggregation
Liewei Wang
Mayo Clinic College of Medicine, Rochester, MN

Ubiquitination of b-arrestin links seven-transmembrane receptor endocytosis and ERK activation  
Sudha Shenoy
Duke University Medical Center, Durham, NC

3:25 p.m. Closing Comments and Adjourn
Edward T. H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX


© 2014 The University of Texas MD Anderson Cancer Center