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SUMO 2004 Past Program

Conference Program 2004

Thursday, February 5

7:00 a.m. Registration, Poster Assignment and Continental Breakfast

8:00 Welcome
Edward T.H. Yeh, M.D.
The University of Texas MD Anderson Cancer Center

8:10 - 10:10 Session I

Moderator: Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel

Roles of the ubiquitin system in the control of cell division
Avram Hershko
Technion-Israel Institute of Technology, Haifa Israel

Control of the SCFSkp2-Cks1 ubiquitin ligase by the APC/CCdh1 ubiquitin ligase
Michele Pagano
New York University School of Medicine and NYU Cancer Institute, New York, NY

Role of the RING finger E3 ligase Siah2 in stress and hypoxia
Ze’ev Ronai
Mount Sinai School of Medicine, New York, NY

The role of the BRCA1/BARD1 ubiquitin ligase in the DNA damage response
Kevin Hiom
Medical Research Council, Cambridge, UK

14-3-3 s negatively regulates MDM2-mediated p53 ubiquitination and is a positive regulator of p53
Mong-Hong Lee
MD Anderson Cancer Center, Houston, TX

10:15 - 10:45 Break

10:45-12:00 p.m. Session II

Moderator: Michele Pagano
New York University School of Medicine and NYU Cancer Institute, New York, NY

Mechanisms and regulation of proteasome function
George N. DeMartino
The University of Texas Southwestern Medical Center, Dallas, TX

The ubiquitin/26S proteasome pathway for the repair of topoisomerase-mediated DNA damage
Leroy F. Liu
UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ

Gankyrin: liver oncoprotein, 26S proteasomal subunit and regulator of tumour suppressor ubiquitylation and degradation
R. John Mayer
University of Nottingham Medical School, Nottingham, UK

12:00 p.m. Lunch

1:15 - 3:15 Session III

Moderator: Huda Y. Zoghbi
Baylor College of Medicine, Houston, TX

Nuclear receptor turnover mediated by coactivators and the proteasome
Bert O’Malley
Baylor College of Medicine, Houston, TX

Transcriptional control and the ubiquitin–proteasome system
William P. Tansey
Cold Spring Harbor Laboratory, NY

Role of SUMO modification in transcriptional regulation
Ronald T. Hay
University of St. Andrews, St. Andrews, Scotland

Kaposi's sarcoma herpesvirus-encoded K-bZIP functions as a global gene silencer and a potential SUMO ligase
Hsing-Jien Kung
University of California Davis Cancer Center, Davis, CA

3:20 - 3:50 Break

3:30 - 6:30 Session IV: Poster Presentations

Presenters are asked to be at their posters during the following times:

  • 3:30-5:00 Even-numbered presenters
  • 5:00-6:30 Odd-numbered presenters


Friday, February 6, 2004

7:00 a.m. Poster Assignment and Continental Breakfast

8:00 - 10:00 Session V

Moderator Michael J. Matunis
Johns Hopkins University, Baltimore, MD

Role of desumoylation in transcriptional regulation
Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center

Functional domains of Siz/PIAS E3s for SUMO
Erica S. Johnson
Thomas Jefferson University, Philadelphia, PA

Structural Insights into SUMO protein modification
Christopher D. Lima
Sloan-Kettering Institute, New York, NY

Sumoylation of p53, p51 and Mdm2, and its effect on their functions
Hideyo Yasuda
Tokyo University, Tokyo, Japan

10:05 - 10:30 Break

10:30 - 11:30 Session VI

Moderator: Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center

SUMO modification and regulation of mRNA biogenesis
Michael J. Matunis
Johns Hopkins University, Baltimore, MD

The RanBP2 E3 ligase - not a HECT E3, but more than an adaptor
Andrea Pichler
Max Planck Institute for Biochemistry, Munich, Germany

12:00 - 1:00 p.m. Session VII/Lunch

Advances in Oncology Institutional Grand Rounds
Chairman: Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center

Molecular sequelae and clinical implications of use of the small molecule proteasome inhibitor bortezomib (PS-341) for the treatment of multiple myeloma
Constantine S. Mitsiades
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

Efficacy of proteasome inhibitor bortezomib (VELCADE) in relapsed or refractory indolent or aggressive B-cell Non-Hodgkin’s Lymphoma
Andre Goy
The University of Texas MD Anderson Cancer Center

Ubiquitin at the bedside—What the near-term future holds
Dennie V. Jones, Jr.
The University of Texas Medical Branch, Galveston, TX 

1:30 - 3:00 Session VIII

Moderator: Ze’ev Ronai
Mount Sinai School of Medicine, New York, NY

Control of ion channels by the ubiquitin-protein ligase NEDD4-2
Andrew B. Fotia
Hanson Institute, Adelaide, Australia

Ubiquitin-conjugating enzyme UBCH7 modulates steroid receptor function by forming a multiprotein complex with SRC-1 and E6AP
Zafar Nawaz
Creighton University, Omaha, NE

Two isoforms of otubain-1 are epistatic regulators of GRAIL with opposing functions
Luis Soares
Stanford University School of Medicine, Stanford, CA

Int6-A link between turorigensis and proteasome function
Eric Chang
Baylor College of Medicine, Houston, TX

UBA domains and a UBA-like domain in NUB1 and NUB1L
Tetsu Kamitani
The University of Texas MD Anderson Cancer Center

Multiple interactions mediated by the UBL domain of RAD23 suggest a mechanism for substrate delivery important in proteolysis
Hai Rao
The University of Texas Health Science Center, San Antonio, TX

3:05 - 3:30 Break

3:30 - 5:30 Session IX

Moderator Ronald T. Hay
University of St. Andrews, St. Andrews, Scotland

Black death, black spot: The diversity of YopJ-like proteins
Kim Orth
University of Texas Southwestern Medical Center, Dallas, TX

SUMO-2 regulates topoisomerase-II in mitosis
Yoshiaki Azuma
National Institutes of Health, Bethesda, MD

SUMOylation: wresting with TGF-ß signaling and transcription
Xin-Hua Feng
Baylor College of Medicine, Houston, TX

Molecular mechanism of histone monoubiquitination in the regulation of gene expression
Ali Shilatifard
Saint Louis University Medical Center, St. Louis, MO

b-arrestin ubiquitination and deubiquitination dictate its trafficking patterns during 7 membrane spanning receptor endocytosis
Sudha K. Shenoy
Duke University Medical Center, Durham, NC

A clinical proteomic approach to cancer: What the patients tell us about their ubiquitin system
Ira L. Goldknopf
ProteEx, The Woodlands, TX

5:45 - 8:45 Session X: Poster Presentations

Presenters are asked to be at their posters during the following times:

  • 5:45 – 7:15 Even-numbered presenters
  • 7:15 – 8:45 Odd-numbered presenters

6:30 - 8:00 Informal Texas-style dinner reception

Saturday, February 7, 2004

7:30 a.m. Continental Breakfast

8:00 - 10:00 Session XI

Moderator: Avram Hershko
Technion-Israel Institute of Technology, Haifa Israel

Mechanisms of processing of NF-kB p105 and p100 precursors: Role of distinct lysine residues
Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel

Ubiquitin signaling in the NF-kappaB pathway
James Chen
The University of Texas Southwestern Medical Center, Dallas, TX

The importance of protein modifications and degradation in neurodegenerative diseases
Huda Y. Zoghbi
Baylor College of Medicine, Houston, TX

Protein modification by ISG15 (UCRP)
Dong-Er Zhang
The Scripps Research Institute, La Jolla, CA

10:05 - 10:30 Break

10:30 - 12:00 p.m. Session XII

Moderator: William P. Tansey
Cold Spring Harbor Laboratory, NY

The Cullin-ROC family of ubiquitin ligases
Yue Xiong
University of North Carolina at Chapel Hill, NC

Disruption of COP9 signalosome Csn2 subunit in mouse causes deficient cell proliferation and early lethality
Ning Wei
Yale University, New Haven, CT

Tumor suppressor ARF degrades nucleolar B23 through the ubiquitin-proteosome pathway
Yanping Zhang
The University of Texas MD Anderson Cancer Center

Closing Comments
Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center

12:00 Adjourn


© 2014 The University of Texas MD Anderson Cancer Center