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SUMO 2002 Past Program

1st International Conference Program

The First International Conference
Ubiquitin, Ubiquitin-Like Proteins, and Cancer
Organized by Edward T. H. Yeh, M.D.
Hickey Auditorium, 11th Floor, R. Lee Clark Clinic
University of Texas MD Anderson Cancer Center, Houston, Texas

Friday, January 25, 2002

Introductory Lectures (open to the entire Texas Medical Center)

3:00 Welcome and Introduction

Margaret Kripke
University of Texas MD Anderson Cancer Center, Houston, Texas

The ubiquitin system for protein degradation and some of its roles in cell cycle control
Avram Hershko
Technion-Israel, Institute of Technology, Haifa, Israel

Ubiquitin-like proteins and cancer
Edward T. H. Yeh
University of Texas MD Anderson Cancer Center, Houston, Texas

4:30 - 5:00 Reception

Saturday, January 26, 2002

7:00 Registration and Continental Breakfast

8:25 Welcome

Edward T. H. Yeh
University of Texas MD Anderson Cancer Center, Houston, Texas

8:30 Introduction

John Mendelsohn
University of Texas MD Anderson Cancer Center, Houston, Texas

8:40 Opening Lecture

The N-end rule pathway and its functions in chromosome segregation, peptide import, meiosis, and angiogenesis
Alexander Varshavsky
California Institute of Technology, Pasadena, California

Session I - 9:10 - 11:30
Moderator: Edward T. H. Yeh
University of Texas MD Anderson Cancer Center, Houston, Texas

Control of cell cycle transitions by the SCF ubiquitin ligase
Wade Harper
Baylor College of Medicine, Houston, Texas

Control of cell proliferation by SCF ligases
Michele Pagano
New York University School of Medicine, New York, New York.

Crystal structure of the Cul1-Rbx1-Skp1-F Box-Skp2 SCF ubiquitin ligase complex
Ning Zheng
Memorial Sloan-Kettering Cancer Center, New York, New York

10:15 Break

RING finger ubiquitin protein ligases and the regulation of cellular processes
Allan Weissman
National Cancer Institute, Bethesda, Maryland

Regulation of programmed cell death or apoptosis in a class of proteins, termed inhibitors of apoptosis proteins (Iaps)
Andreas Bergmann
University of Texas MD Anderson Cancer Center, Houston, Texas

Checkpoint control in mitosis and the Dys-Regulation of checkpoint pathways in cancer cells
Guowei Fang
Stanford University, Stanford, California

11:30 Luncheon

Session II - 1:00 - 2:40
Moderator: Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel

Regulation of TRAF2 stability
Zeve Ronai
Mount Sinai School of Medicine, New York, New York

Regulation of DNA repair by ubiquitination
Alan D'Andrea
Dana-Farber Cancer Institute, Boston, Massachusetts

Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1
Tetsu Kamitani
University of Texas MD Anderson Cancer Center, Houston, Texas

Cop9 signalosome regulates Scf mediated degradation of P27kip1 through a mechanism involving Nedd8 de-conjugation of cul1
Ning Wei
Yale University, New Haven, Connecticut

Oxygen-dependent ubiquitination-degradation of hypoxia-inducible factor requires nuclear/cytoplasmic trafficking of the Von Hippel-Lindau tumor suppressor protein
Isabelle Groulx
Ottawa University, Ottawa, Ontario, Canada

2:40 Break

Session III - 3:00 - 4:45
Moderator: Gordon Mills
University of Texas MD Anderson Cancer Center, Houston, Texas

Dynamic localization of components of the proteasome system at nuclear PML bodies
George DeMartino
University of Texas Southwestern Medical Center, Dallas, Texas

The ubiquitin-proteasome system cooperates with molecular chaperones to degrade misfolded proteins
Keiji Tanaka
Presented by Tomoki Chiba
Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

The chaperone dependent degradation of misfolded Von-Hippel lindau (Vhl) tumor suppressor protein by the 26s proteasome system
Melissa Miller
Stanford University, Stanford, California

UBP43 specifically removes ISG15 from conjugated proteins
Michael Malakhova
The Scripps Research Institute, La Jolla, California

Two ubiquitin-like systems essential for autophagy
Yoshinori Ohsumi
National Institute of Basic Biology, Okazaki, Japan

5:00 - 9:00 Session IV

Poster Presentations

6:00 - 7:30 Buffet Dinner

Sunday, January 27, 2002

8:00 Continental Breakfast

Session V- 8:30 - 10:25
Moderator: Edward T. H. Yeh
University of Texas MD Anderson Cancer Center, Houston, Texas

Sentrin-modification in acute promyelocytic leukemia
Edward T. H. Yeh
University of Texas MD Anderson Cancer Center, Houston, Texas

A family of cysteine proteases responsible for cleaving the SUMO-1 and Smt3 ubiquitin-like proteins from substrates
Mark Hochstrasser
Yale University, New Haven, Connecticut

Family of sentrin-specific proteases
Limin Gong
University of Texas MD Anderson Cancer Center, Houston, Texas

Ubiquitin/SUMO-conjugation to topoisomerase cleavable complexes as novel drug resistance mechanisms
Leroy Liu
UMDNJ-Robert Wood Johnson Medical School, Piscataway, New Jersey

Covalent modification of HDAC4 By SUMO-1
Olivier Kirsh
Institut Pasteur, Paris, France

Characterization of SUMO-modified MDM2, E3 for tumor suppressor p53
Hideyo Yasuda
Tokyo University, Hachioji, Tokyo, Japan

10:25 Break

Session VI - 10:40 - 12:00
Moderator: Waun-Ki Hong
University of Texas MD Anderson Cancer Center, Houston, Texas

Mechanisms for activation of ubiquitin-dependent proteolysis in muscle in cancer and other cachectic states
Alfred Goldberg
Harvard Medical School, Boston, Massachusetts

HSP 90 chaperone as a potential target for anti-cancer therapeutics
Neil Rosen
Memorial Sloan-Kettering, New York, New York

Proteasome inhibition as a therapy in advanced prostate cancer
Christos N. Papandreou
University of Texas MD Anderson Cancer Center, Houston, Texas

11:50 Closing Comments
Edward T. H. Yeh
University of Texas MD Anderson Cancer Center, Houston, Texas

12: 00 Adjourn and Lunch


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