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Conference Program

Wednesday, Feb. 10, 2010

7:30 a.m.   Registration and Continental Breakfast

8:25 a.m.   Welcome

Raymond DuBois
The University of Texas MD Anderson Cancer Center, Houston, TX

8:30 - 10:15 a.m.   Session I

Moderator: Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX

8:30 - 9:00Overview

Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX

9:00 - 9:25  How SUMO targets proteins for ubiquitin-mediated proteolysis

Ronald T. Hay
University of Dundee, Dundee, Scotland, UK

9:25 - 9:50  RNF4 structure-function studies and the characterization of Arkadia/RNF111 as a novel SUMO-targeted ubiquitin ligase (STUbL)

Tony Hunter
Salk Institute for Biological Studies, La Jolla, CA

9:50 - 10:15  Role of SUMO-targeted ubiquitin ligases (STUbLs) in genomic stability, specifically through regulation of replication fork stability

Michael N. Boddy
The Scripps Research Institute, La Jolla, CA

10:15 - 10:45 a.m.   Break

10:45 - 11:40 a.m.   Session II

Moderator: Ronald T. Hay
University of Dundee, Dundee Scotland, UK

10:45 - 11:10  SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase (STUbL)

Mark Hochstrasser
Yale University, New Haven, CT

11:10 - 11:25  Degringolade, a SUMO targeted ubiquitin ligase is regulator of the notch pathway and early embryonic patterning

Amir Orian
Technion-Israel Institute of Technology, Haifa, Israel

11:25 - 11:40  Proteolytic control of SUMO conjugates and SUMO recycling

Maria Miteva
University of Cologne, Cologne, Germany

11:40 a.m. - 1:00 p.m.   Lunch

1:00 - 2:25 p.m.   Session III

Moderator: Tony Hunter
Salk Institute for Biological Studies, La Jolla, CA

1:00 - 1:30  Regulation of APC/C ubiquitin ligase in the cell cycle

Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel

1:30 - 1:55  SCF ubiquitin ligases and their involvement in cell cycle control and cancer

Michele Pagano
New York University School of Medicine, New York, NY

1:55 - 2:10  Regulated degradation of spindle assembly factors by the Anaphase-Promoting Complex

Ling Song
University of California at Berkeley, Berkeley, CA

2:10-2:25 E3 Ligases Arf-bp1 and Pam Mediate Lithium-Stimulated Degradation of the Circadian Heme Receptor Rev-erbα

Lei Yin
University of Michigan, Ann Arbor, MI

2:25 - 3:00 p.m.   Break

3:00 - 5:25 p.m.   Session IV

Moderator: Michele Pagano
New York University School of Medicine, New York, NY

3:00 - 3:25  Histone ubquitination/ deubiquitination machineries in the regulation of gene expression and development

Ali Shilatifard
Stowers Institute for Medical Research, Kansas City, MO

3:25 - 3:50  Regulation of chromatin structure and gene expression by SUMO

Grace Gill
Tufts University School of Medicine, Boston, MA

3:50 - 4:15  Role of de-SUMOylation in suppressing Polycomb Group protein-mediated gene silencing during embryonic development

Jinke Cheng/Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX

4:15 - 4:40  SUMO in cardiac function

Robert J. Schwartz
University of Houston, Houston, TX

4:40 - 4:55  Cross-talk between SUMOylation and proteasome function in the regulation of androgen receptor signaling

Jorma Palvimo
Institute of Biomedicine, University of Kuopio, Kuopio, Finland

4:55 - 5:10  Structural and functional aspects of Daxx SUMO-interacting motif regulated by phosphorylation

Hsiu-Ming Shih
Academia Sinica, Taipei, Taiwan

5:10 - 5:25  SUMOylation of KAP1, a transcriptional Co-repressor, is regulated by Ser/Thr phosphatase PP1

David Ann
City of Hope, Duarte, CA

5:30 - 9:30 p.m.   Session V

5:30 - 7:00 p.m.   Poster Session, Even Side and Reception

7:00 - 8:00 p.m.   Dinner Buffet

8:00 - 9:30 p.m.   Poster Session, Odd Side

Thursday, Feb. 11, 2010

7:30 a.m.   Registration and Continental Breakfast

8:30 - 10:25 a.m.   Session VI

Moderator: Christopher D. Lima
Sloan-Kettering Institute, New York, NY

8:30 - 9:00  Degradation of the ubiquitin system components by the ubiquitin system

Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel

9:00 - 9:25  Proteasome-associated deubiquitylation

George N. DeMartino
The University of Texas Southwestern Medical Center, Dallas, TX

9:25 - 9:40  Conditional regional genetic ablation of a 26S proteasomal ATPase gene in the mouse brain recapitulates features of Parkinson’s disease and dementia with Lewy bodies

R. John Mayer
University of Nottingham, Nottingham, United Kingdom

9:40 - 9:55  Inflammation and protein aggregation: A missing link in neurodegeneration

Maria Figueiredo-Pereira
Hunter College, City University of New York, New York, NY

9:55 - 10:10  Lipid metabolites-regulated proteasomal degradation of Insig-1

Jin Ye
The University of Texas Southwestern Medical Center, Dallas, TX

10:10 - 10:25  Control of cullin-ring ubiquitin ligases by the Cop9 signalosome and CAND1   

Dieter Wolf
Burnham Institute for Medical Research, La Jolla, CA

10:25 - 11:00 a.m.   Break

11:00 a.m. - 12:20 p.m.   Session VII

Moderator: Brenda A. Schulman
St. Jude Children's Research Hospital, Memphis, TN

11:00 - 11:25  Ubiquitin signaling in antiviral innate immunity

Zhijian 'James' Chen
The University of Texas Southwestern Medical Center, Dallas, TX

11:25 - 11:40  Regulation of Akt signaling activation by ubiquitination

Hui-Kuan Lin
The University of Texas MD Anderson Cancer Center, Houston, TX

11:40 - 12:05  SUMO and NF-kB connections

Shigeki Miyamoto
University of Wisconsin-Madison, Madison, WI

12:05 - 12:20  Novel effects of SUMOylation in androgen receptor based diseases

Jorge Iniguez-Liuhi
University of Michigan Medical School, Ann Arbor, MI

12:20 - 1:30 p.m.   Lunch

1:30 - 3:00 p.m.   Session VIII

Moderator: Allan M. Weissman
National Cancer Institute, Frederick, MD

1:30 - 1:55  Mechanisms that underlie SUMO/Ub activation and thioester transfer within the E1 enzyme

Christopher D. Lima
Sloan-Kettering Institute, New York, NY

1:55 - 2:20  Molecular mechanism of action of the NAE inhibitor, MLN4924

James Brownell
Millennium: The Takeda Oncology Company, Cambridge, MA

2:20 - 2:45  Structural insights into a HECT ubiquitin ligase

Brenda A. Schulman
St. Jude Children's Research Hospital, Memphis, TN

2:45 - 3:00  Multiple mechanisms to prevent crosstalk between Uba1- and Uba6-activated ubiquitin conjugation cascades

Jianping Jin
The University of Texas Medical School at Houston, Houston, TX

3:00 - 3:35 p.m.   Break

3:35 - 5:40 p.m.   Session IX

Moderator: Zhijian 'James' Chen
The University of Texas Southwestern Medical Center, Dallas, TX

3:35 - 4:00  Ubiquitin/ISG15 crosstalk in tumorigenesis

Shyamal D. Desai
LSU-Health Sciences Center-School of Medicine, New Orleans, LA

4:00 - 4:15  The ISG15 ligase, Herc5, is ribosome-associated and broadly targets newly synthesized proteins

Jon Huibregtse
The University of Texas at Austin, Austin, TX

4:15 - 4:30  The mechanism by which ISG15 conjugation inhibits the replication of influenza A viruses

Robert Krug
The University of Texas at Austin, Austin, TX

4:30 - 4:55  Catching UBC on the flip side: Insights into E3 function

Allan M. Weissman
National Cancer Institute, Frederick, MD

4:55 - 5:10  A bona fide degradation signal targets a mutant kinetochore protein for destruction via endoplasmic reticulum associated degradation (ERAD)

Tommer Ravid
The Hebrew University of Jerusalem, Jerusalem, Israel

5:10 - 5:25  Coordinated regulation of protein synthesis and degradation as regulated by Int6/eIF3e

Eric Chang
Baylor College of Medicine, Houston, TX

5:25 - 5:40  REGg regulates p53 by facilitating its monoubiquitination

Xiaotao Li
Baylor College of Medicine, Houston, TX

Friday, Feb. 12, 2010

7:30 a.m.   Registration and Continental Breakfast

8:30 - 10:35 a.m.   Session X

Moderator: Michael J. Matunis
Johns Hopkins University, Baltimore, MD

8:30 - 8:55  Regulation of the Fanconi anemia pathway by deubiquitination

Alan D'Andrea
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

8:55 - 9:20  Assembly and function of K63-linked polyubiquitin chains in DNA damage bypass

Helle D. Ulrich
London Research Institute, South Mimms, UK

9:20 - 9:45  The role of one SENP in yeast, Ulp2, on promoting replication and genome integrity

Dana Branzei
F.I.R.C. Institute of Molecular Oncology, Milan, Italy

9:45 - 10:10  Regulation of DNA replication and repair through a SUMOylation and de-SUMOylation switch

Hong Dou and Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX

10:10 - 10:35  DNA damage signaling and DNA repair

Junjie Chen
The University of Texas MD Anderson Cancer Center, Houston, TX

10:35 - 11:00 a.m.   Break 

11:00 - 11:30 a.m.   Session XI

Moderator: Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, MD

11:00 - 11:15  The COP9 signalosome mediates the degradation of β-catenin

Wolfgang Dubiel
Universitätsmedizin Berlin, Berlin, Germany

11:15 - 11:30  Tankyrase inhibition stabilizes axin and antagonizes Wnt/β-catenin signalling–a novel mechanism revealed in chemical genetic and proteomic screen

Shih-Min 'Alex' Huang
Novartis Institutes for Biomedical Research, Cambridge, MA

11:30 - 1:15 p.m.   Lunch

Noon - 1:00 p.m.   Institutional Grand Rounds

SUMO, NEDD8, Ubiquitin: Targets for cancer therapy

Session Chair: Edward TH Yeh, MD, Professor and Chair, Cardiology

12:00 - 12:15 — SUMO, NEDD8, Ubiquitin: Targets for cancer therapy  Overview

Edward TH Yeh, MD, Professor and Chair, Cardiology

12:15 - 12:35 — NEDD8-Activating enzyme as a target for cancer therapy  Pre-clinical studies

Teresa Soucy, PhD, Senior Scientist, Oncology Biochemistry
Millennium: The Takeda Oncology Company

12:35 - 12:55 — NEDD8-Activating enzyme as a target for cancer therapy  Phase I clinical study

Jatin Shah, MD, Assistant Professor, Department of Lymphoma/Myeloma

12:55 - 1:00 - Question and Answer Session

1:15 - 2:50 p.m.   Session XII

Moderator: Alan D'Andrea
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA

1:15 - 1:40  The role of SUMO modification in regulating chromosome segregation

Michael J. Matunis
Johns Hopkins University, Baltimore, MD

1:40 - 2:05  SUMOylation and mitotic chromosome segregation

Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, MD

2:05 - 2:20  The regulation of PIASy-dependent SUMOylation on mitotic chromosomal proteins

Yoshiaki Azuma
University of Kansas, Lawrence, KS

2:20 - 2:35  SUMOylation regulates telomere metabolisms via multiple mechanisms

Xiaolan Zhao
Memorial Sloan Kettering Cancer Center, New York, NY

2:35 - 2:50  Mitochondria to peroxisome transport of the SUMO E3 ligase MAPL requires the VPS35 retromer complex

Heidi McBride
University of Ottawa Heart Institute, Ottawa, ON, Canada

2:50 - 3:25 p.m.   Break

3:25 - 5:00 p.m.   Session XIII

Moderator   Guo-Qiang Chen
Shanghai Jiao Tong University School of Medicine, Shanghai, China

3:25 - 3:50  The role of the ubiquitin ligase Siah in control of neuroendocrine prostate tumor development

Ze'ev Ronai
The Burnham Institute, La Jolla, CA

3:50 - 4:15  Negative regulation of JAK2 via VHL-SOCS1 heteroE3 duplex

Michael Ohh
University of Toronto, Toronto, ON, Canada

4:15 - 4:30  MAGE cancer-testis antigens form E3 ubiquitin ligases that promote p53 degradation

Patrick Ryan Potts
The University of Texas Southwestern Medical Center, Dallas, TX

4:30 - 4:45  ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death

Lilliana Radoshevich
University of California, San Francisco, CA

4:45 - 5:00  Human SLX4, ubiquitin and genome stability

Pierre-Henri Gaillard
CNRS, Marseille, France

5:30 - 9:30 p.m.   Session XIV

5:30 - 7:00 p.m.   Poster Session, Even Side and Reception

7:00 - 8:00 p.m.   Dinner Buffet

8:00 - 9:30 p.m.   Poster Session, Odd Side

Saturday, Feb. 13, 2010

7:30 a.m.   Continental Breakfast

8:30 - 9:50 a.m.   Session XV

Moderator: Hsing-Jien Kung
University of California Davis Cancer Center, Sacramento, CA

8:30 - 8:55  Molecular mechanisms of muscle atropy and cachexia

Alfred Goldberg
Harvard Medical School, Boston MA

8:55 - 9:20  Signaling pathways that mediate skeletal muscle hypertrophy and atrophy

David J. Glass
Novartis Institutes for BioMedical Research Inc., Cambridge, MA

9:20 - 9:35  The ubiquitin ligase Atrogin-1, but not MuRF-1, is required for atrophic remodeling of the heart

Kedryn Baskin
The University of Texas Health Science Center, Houston, TX

9:35 - 9:50  Cancer causes cardiac atrophy in vivo, potentially through interferon-gamma stimulated specific degradation of cardiac myosin heavy chain

Pippa Cosper
University of Colorado, Boulder, CO

9:50 - 10:25 a.m.   Break

10:25 a.m. - 12:40 p.m.   Session XVI

Moderator: Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX

10:25 - 10:50  Regulation of the SUMO system, and SUMO chains

Brian Raught
Ontario Cancer Institute, Toronto, Ontario, Canada

10:50 - 11:15  SUMO attachment to a subunit of RNA polymerase II

Erica S. Johnson
Thomas Jefferson University, Philadelphia, PA

11:15 - 11:40  SUMO dynamics and KSHV replication

Hsing-Jien Kung
University of California Davis Cancer Center, Sacramento, CA

11:40 - 11:55  Evidence for a role of pmL in mediating the SUMOylation of the human cytomegalovirus regulatory protein IE1p72

Thomas Stamminger
Institute for Clinical and Molecular Virology, Erlangen, Germany

11:55 - 12:10  Listeria monocytogenes impairs SUMOylation for efficient infection

Pascale Cossart
Institut Pasteur, Paris, France

12:10 - 12:25  NEDDylation and DENEDDylation in Aspergillus nidulans development

Gerhard Braus
Institute of Microbiology and Genetics, Goettingen, Germany

12:25 - 12:40  A viral E3 ubiquitin ligase targets cellular E3 ubiquitin ligases to modulate histone ubiquitination: Implications for viral latency and reactivation

Mira Chaurushiya
The Salk Institute for Biological Studies, La Jolla, CA

Closing Comments and Adjourn

Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX

Box lunch pickup


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