Conference Program
Wednesday, Feb. 10, 2010
7:30 a.m. Registration and Continental Breakfast
8:25 a.m. Welcome
Raymond DuBois
The University of Texas MD Anderson Cancer Center, Houston, TX
8:30 - 10:15 a.m. Session I
Moderator: Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX
8:30 - 9:00 — Overview
Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX
9:00 - 9:25 — How SUMO targets proteins for ubiquitin-mediated proteolysis
Ronald T. Hay
University of Dundee, Dundee, Scotland, UK
9:25 - 9:50 — RNF4 structure-function studies and the characterization of Arkadia/RNF111 as a novel SUMO-targeted ubiquitin ligase (STUbL)
Tony Hunter
Salk Institute for Biological Studies, La Jolla, CA
9:50 - 10:15 — Role of SUMO-targeted ubiquitin ligases (STUbLs) in genomic stability, specifically through regulation of replication fork stability
Michael N. Boddy
The Scripps Research Institute, La Jolla, CA
10:15 - 10:45 a.m. Break
10:45 - 11:40 a.m. Session II
Moderator: Ronald T. Hay
University of Dundee, Dundee Scotland, UK
10:45 - 11:10 — SUMO-independent in vivo activity of a SUMO-targeted ubiquitin ligase (STUbL)
Mark Hochstrasser
Yale University, New Haven, CT
11:10 - 11:25 — Degringolade, a SUMO targeted ubiquitin ligase is regulator of the notch pathway and early embryonic patterning
Amir Orian
Technion-Israel Institute of Technology, Haifa, Israel
11:25 - 11:40 — Proteolytic control of SUMO conjugates and SUMO recycling
Maria Miteva
University of Cologne, Cologne, Germany
11:40 a.m. - 1:00 p.m. Lunch
1:00 - 2:25 p.m. Session III
Moderator: Tony Hunter
Salk Institute for Biological Studies, La Jolla, CA
1:00 - 1:30 — Regulation of APC/C ubiquitin ligase in the cell cycle
Avram Hershko
Technion-Israel Institute of Technology, Haifa, Israel
1:30 - 1:55 — SCF ubiquitin ligases and their involvement in cell cycle control and cancer
Michele Pagano
New York University School of Medicine, New York, NY
1:55 - 2:10 — Regulated degradation of spindle assembly factors by the Anaphase-Promoting Complex
Ling Song
University of California at Berkeley, Berkeley, CA
2:10-2:25 E3 Ligases Arf-bp1 and Pam Mediate Lithium-Stimulated Degradation of the Circadian Heme Receptor Rev-erbα
Lei Yin
University of Michigan, Ann Arbor, MI
2:25 - 3:00 p.m. Break
3:00 - 5:25 p.m. Session IV
Moderator: Michele Pagano
New York University School of Medicine, New York, NY
3:00 - 3:25 — Histone ubquitination/ deubiquitination machineries in the regulation of gene expression and development
Ali Shilatifard
Stowers Institute for Medical Research, Kansas City, MO
3:25 - 3:50 — Regulation of chromatin structure and gene expression by SUMO
Grace Gill
Tufts University School of Medicine, Boston, MA
3:50 - 4:15 — Role of de-SUMOylation in suppressing Polycomb Group protein-mediated gene silencing during embryonic development
Jinke Cheng/Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX
4:15 - 4:40 — SUMO in cardiac function
Robert J. Schwartz
University of Houston, Houston, TX
4:40 - 4:55 — Cross-talk between SUMOylation and proteasome function in the regulation of androgen receptor signaling
Jorma Palvimo
Institute of Biomedicine, University of Kuopio, Kuopio, Finland
4:55 - 5:10 — Structural and functional aspects of Daxx SUMO-interacting motif regulated by phosphorylation
Hsiu-Ming Shih
Academia Sinica, Taipei, Taiwan
5:10 - 5:25 — SUMOylation of KAP1, a transcriptional Co-repressor, is regulated by Ser/Thr phosphatase PP1
David Ann
City of Hope, Duarte, CA
5:30 - 9:30 p.m. Session V
5:30 - 7:00 p.m. Poster Session, Even Side and Reception
7:00 - 8:00 p.m. Dinner Buffet
8:00 - 9:30 p.m. Poster Session, Odd Side
Thursday, Feb. 11, 2010
7:30 a.m. Registration and Continental Breakfast
8:30 - 10:25 a.m. Session VI
Moderator: Christopher D. Lima
Sloan-Kettering Institute, New York, NY
8:30 - 9:00 — Degradation of the ubiquitin system components by the ubiquitin system
Aaron Ciechanover
Technion-Israel Institute of Technology, Haifa, Israel
9:00 - 9:25 — Proteasome-associated deubiquitylation
George N. DeMartino
The University of Texas Southwestern Medical Center, Dallas, TX
9:25 - 9:40 — Conditional regional genetic ablation of a 26S proteasomal ATPase gene in the mouse brain recapitulates features of Parkinson’s disease and dementia with Lewy bodies
R. John Mayer
University of Nottingham, Nottingham, United Kingdom
9:40 - 9:55 — Inflammation and protein aggregation: A missing link in neurodegeneration
Maria Figueiredo-Pereira
Hunter College, City University of New York, New York, NY
9:55 - 10:10 — Lipid metabolites-regulated proteasomal degradation of Insig-1
Jin Ye
The University of Texas Southwestern Medical Center, Dallas, TX
10:10 - 10:25 — Control of cullin-ring ubiquitin ligases by the Cop9 signalosome and CAND1
Dieter Wolf
Burnham Institute for Medical Research, La Jolla, CA
10:25 - 11:00 a.m. Break
11:00 a.m. - 12:20 p.m. Session VII
Moderator: Brenda A. Schulman
St. Jude Children's Research Hospital, Memphis, TN
11:00 - 11:25 — Ubiquitin signaling in antiviral innate immunity
Zhijian 'James' Chen
The University of Texas Southwestern Medical Center, Dallas, TX
11:25 - 11:40 — Regulation of Akt signaling activation by ubiquitination
Hui-Kuan Lin
The University of Texas MD Anderson Cancer Center, Houston, TX
11:40 - 12:05 — SUMO and NF-kB connections
Shigeki Miyamoto
University of Wisconsin-Madison, Madison, WI
12:05 - 12:20 — Novel effects of SUMOylation in androgen receptor based diseases
Jorge Iniguez-Liuhi
University of Michigan Medical School, Ann Arbor, MI
12:20 - 1:30 p.m. Lunch
1:30 - 3:00 p.m. Session VIII
Moderator: Allan M. Weissman
National Cancer Institute, Frederick, MD
1:30 - 1:55 — Mechanisms that underlie SUMO/Ub activation and thioester transfer within the E1 enzyme
Christopher D. Lima
Sloan-Kettering Institute, New York, NY
1:55 - 2:20 — Molecular mechanism of action of the NAE inhibitor, MLN4924
James Brownell
Millennium: The Takeda Oncology Company, Cambridge, MA
2:20 - 2:45 — Structural insights into a HECT ubiquitin ligase
Brenda A. Schulman
St. Jude Children's Research Hospital, Memphis, TN
2:45 - 3:00 — Multiple mechanisms to prevent crosstalk between Uba1- and Uba6-activated ubiquitin conjugation cascades
Jianping Jin
The University of Texas Medical School at Houston, Houston, TX
3:00 - 3:35 p.m. Break
3:35 - 5:40 p.m. Session IX
Moderator: Zhijian 'James' Chen
The University of Texas Southwestern Medical Center, Dallas, TX
3:35 - 4:00 — Ubiquitin/ISG15 crosstalk in tumorigenesis
Shyamal D. Desai
LSU-Health Sciences Center-School of Medicine, New Orleans, LA
4:00 - 4:15 — The ISG15 ligase, Herc5, is ribosome-associated and broadly targets newly synthesized proteins
Jon Huibregtse
The University of Texas at Austin, Austin, TX
4:15 - 4:30 — The mechanism by which ISG15 conjugation inhibits the replication of influenza A viruses
Robert Krug
The University of Texas at Austin, Austin, TX
4:30 - 4:55 — Catching UBC on the flip side: Insights into E3 function
Allan M. Weissman
National Cancer Institute, Frederick, MD
4:55 - 5:10 — A bona fide degradation signal targets a mutant kinetochore protein for destruction via endoplasmic reticulum associated degradation (ERAD)
Tommer Ravid
The Hebrew University of Jerusalem, Jerusalem, Israel
5:10 - 5:25 — Coordinated regulation of protein synthesis and degradation as regulated by Int6/eIF3e
Eric Chang
Baylor College of Medicine, Houston, TX
5:25 - 5:40 — REGg regulates p53 by facilitating its monoubiquitination
Xiaotao Li
Baylor College of Medicine, Houston, TX
Friday, Feb. 12, 2010
7:30 a.m. Registration and Continental Breakfast
8:30 - 10:35 a.m. Session X
Moderator: Michael J. Matunis
Johns Hopkins University, Baltimore, MD
8:30 - 8:55 — Regulation of the Fanconi anemia pathway by deubiquitination
Alan D'Andrea
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
8:55 - 9:20 — Assembly and function of K63-linked polyubiquitin chains in DNA damage bypass
Helle D. Ulrich
London Research Institute, South Mimms, UK
9:20 - 9:45 — The role of one SENP in yeast, Ulp2, on promoting replication and genome integrity
Dana Branzei
F.I.R.C. Institute of Molecular Oncology, Milan, Italy
9:45 - 10:10 — Regulation of DNA replication and repair through a SUMOylation and de-SUMOylation switch
Hong Dou and Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX
10:10 - 10:35 — DNA damage signaling and DNA repair
Junjie Chen
The University of Texas MD Anderson Cancer Center, Houston, TX
10:35 - 11:00 a.m. Break
11:00 - 11:30 a.m. Session XI
Moderator: Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, MD
11:00 - 11:15 — The COP9 signalosome mediates the degradation of β-catenin
Wolfgang Dubiel
Universitätsmedizin Berlin, Berlin, Germany
11:15 - 11:30 — Tankyrase inhibition stabilizes axin and antagonizes Wnt/β-catenin signalling–a novel mechanism revealed in chemical genetic and proteomic screen
Shih-Min 'Alex' Huang
Novartis Institutes for Biomedical Research, Cambridge, MA
11:30 - 1:15 p.m. Lunch
Noon - 1:00 p.m. Institutional Grand Rounds
SUMO, NEDD8, Ubiquitin: Targets for cancer therapy
Session Chair: Edward TH Yeh, MD, Professor and Chair, Cardiology
12:00 - 12:15 — SUMO, NEDD8, Ubiquitin: Targets for cancer therapy Overview
Edward TH Yeh, MD, Professor and Chair, Cardiology
12:15 - 12:35 — NEDD8-Activating enzyme as a target for cancer therapy Pre-clinical studies
Teresa Soucy, PhD, Senior Scientist, Oncology Biochemistry
Millennium: The Takeda Oncology Company
12:35 - 12:55 — NEDD8-Activating enzyme as a target for cancer therapy Phase I clinical study
Jatin Shah, MD, Assistant Professor, Department of Lymphoma/Myeloma
12:55 - 1:00 - Question and Answer Session
1:15 - 2:50 p.m. Session XII
Moderator: Alan D'Andrea
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA
1:15 - 1:40 — The role of SUMO modification in regulating chromosome segregation
Michael J. Matunis
Johns Hopkins University, Baltimore, MD
1:40 - 2:05 — SUMOylation and mitotic chromosome segregation
Mary Dasso
National Institutes of Health, LGRD, NICHD, Bethesda, MD
2:05 - 2:20 — The regulation of PIASy-dependent SUMOylation on mitotic chromosomal proteins
Yoshiaki Azuma
University of Kansas, Lawrence, KS
2:20 - 2:35 — SUMOylation regulates telomere metabolisms via multiple mechanisms
Xiaolan Zhao
Memorial Sloan Kettering Cancer Center, New York, NY
2:35 - 2:50 — Mitochondria to peroxisome transport of the SUMO E3 ligase MAPL requires the VPS35 retromer complex
Heidi McBride
University of Ottawa Heart Institute, Ottawa, ON, Canada
2:50 - 3:25 p.m. Break
3:25 - 5:00 p.m. Session XIII
Moderator Guo-Qiang Chen
Shanghai Jiao Tong University School of Medicine, Shanghai, China
3:25 - 3:50 — The role of the ubiquitin ligase Siah in control of neuroendocrine prostate tumor development
Ze'ev Ronai
The Burnham Institute, La Jolla, CA
3:50 - 4:15 — Negative regulation of JAK2 via VHL-SOCS1 heteroE3 duplex
Michael Ohh
University of Toronto, Toronto, ON, Canada
4:15 - 4:30 — MAGE cancer-testis antigens form E3 ubiquitin ligases that promote p53 degradation
Patrick Ryan Potts
The University of Texas Southwestern Medical Center, Dallas, TX
4:30 - 4:45 — ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death
Lilliana Radoshevich
University of California, San Francisco, CA
4:45 - 5:00 — Human SLX4, ubiquitin and genome stability
Pierre-Henri Gaillard
CNRS, Marseille, France
5:30 - 9:30 p.m. Session XIV
5:30 - 7:00 p.m. Poster Session, Even Side and Reception
7:00 - 8:00 p.m. Dinner Buffet
8:00 - 9:30 p.m. Poster Session, Odd Side
Saturday, Feb. 13, 2010
7:30 a.m. Continental Breakfast
8:30 - 9:50 a.m. Session XV
Moderator: Hsing-Jien Kung
University of California Davis Cancer Center, Sacramento, CA
8:30 - 8:55 — Molecular mechanisms of muscle atropy and cachexia
Alfred Goldberg
Harvard Medical School, Boston MA
8:55 - 9:20 — Signaling pathways that mediate skeletal muscle hypertrophy and atrophy
David J. Glass
Novartis Institutes for BioMedical Research Inc., Cambridge, MA
9:20 - 9:35 — The ubiquitin ligase Atrogin-1, but not MuRF-1, is required for atrophic remodeling of the heart
Kedryn Baskin
The University of Texas Health Science Center, Houston, TX
9:35 - 9:50 — Cancer causes cardiac atrophy in vivo, potentially through interferon-gamma stimulated specific degradation of cardiac myosin heavy chain
Pippa Cosper
University of Colorado, Boulder, CO
9:50 - 10:25 a.m. Break
10:25 a.m. - 12:40 p.m. Session XVI
Moderator: Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX
10:25 - 10:50 — Regulation of the SUMO system, and SUMO chains
Brian Raught
Ontario Cancer Institute, Toronto, Ontario, Canada
10:50 - 11:15 — SUMO attachment to a subunit of RNA polymerase II
Erica S. Johnson
Thomas Jefferson University, Philadelphia, PA
11:15 - 11:40 — SUMO dynamics and KSHV replication
Hsing-Jien Kung
University of California Davis Cancer Center, Sacramento, CA
11:40 - 11:55 — Evidence for a role of pmL in mediating the SUMOylation of the human cytomegalovirus regulatory protein IE1p72
Thomas Stamminger
Institute for Clinical and Molecular Virology, Erlangen, Germany
11:55 - 12:10 — Listeria monocytogenes impairs SUMOylation for efficient infection
Pascale Cossart
Institut Pasteur, Paris, France
12:10 - 12:25 — NEDDylation and DENEDDylation in Aspergillus nidulans development
Gerhard Braus
Institute of Microbiology and Genetics, Goettingen, Germany
12:25 - 12:40 — A viral E3 ubiquitin ligase targets cellular E3 ubiquitin ligases to modulate histone ubiquitination: Implications for viral latency and reactivation
Mira Chaurushiya
The Salk Institute for Biological Studies, La Jolla, CA
Closing Comments and Adjourn
Edward T.H. Yeh
The University of Texas MD Anderson Cancer Center, Houston, TX