Selected Publications
From the Department of Cardiology on cancer and the heart
Identification of the Molecular Basis of Doxorubicin-Induced Cardiotoxicity.
Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, Yeh ET.
Nat Med. e-Pub 10/28/2012. PMID: 23104132.
Radiation-related heart disease: current knowledge and future prospects.
Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K, Mabuchi K, Marks LB, Mettler FA, Pierce LJ, Trott KR, Yeh ET, Shore RE. Int J Radiat Oncol Biol Phys. 2010 Mar 1;76(3):656-65. Review.
Cardiomyocyte PDGFR-beta signaling is an essential component of the mouse cardiac response to load-induced stress.
Chintalgattu V, Ai D, Langley RR, Zhang J, Bankson JA, Shih TL, Reddy AK, Coombes KR, Daher IN, Pati S, Patel SS, Pocius JS, Taffet GE, Buja LM, Entman ML, Khakoo AY. J Clin Invest. 2010 Feb 1;120(2):472-84. doi: 10.1172/JCI39434. Epub 2010 Jan 11.PMID: 20071776 [PubMed - indexed for MEDLINE]
Rare incidence of congestive heart failure in gastrointestinal stromal tumor and other sarcoma patients receiving imatinib mesylate.
Trent JC, Patel SS, Zhang J, Araujo DM, Plana JC, Lenihan DJ, Fan D, Patel SR, Benjamin RS, Khakoo AY. Cancer. 2010 Jan 1;116(1):184-92.
Long-term cardiac safety of dose-dense anthracycline therapy cannot be predicted from early ejection fraction data.
Ewer MS, Ewer SM. J Clin Oncol. 2009 Dec 20;27(36):6073-5. Epub 2009 Nov 9. No abstract available. PMID: 19901128 [PubMed - indexed for MEDLINE]
Related articles
Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management.
Yeh ET, Bickford CL. J Am Coll Cardiol. 2009 Jun 16;53(24):2231-47. Review.PMID: 19520246 [PubMed - indexed for MEDLINE]
A woman's heart: the impact of adjuvant endocrine therapy on cardiovascular health.
Ewer MS, Glück S. Cancer. 2009 May 1;115(9):1813-26. Review.PMID: 19235248 [PubMed - indexed for MEDLINE]
Therapy insight: Management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy.
Khakoo AY, Yeh ET. Nat Clin Pract Oncol. 2008 Nov;5(11):655-67. Epub 2008 Sep 16. Review.PMID: 18797437 [PubMed - indexed for MEDLINE]
Sunitinib-related cardiotoxicity: an interdisciplinary issue.
Ewer MS, Lenihan DJ, Khakoo AY. Nat Clin Pract Cardiovasc Med. 2008 Jul;5(7):364-5. Epub 2008 May 20. No abstract available. PMID: 18490940 [PubMed]
Related articles
Heart failure associated with sunitinib malate: a multitargeted receptor tyrosine kinase inhibitor.
Khakoo AY, Kassiotis CM, Tannir N, Plana JC, Halushka M, Bickford C, Trent J 2nd, Champion JC, Durand JB, Lenihan DJ. Cancer. 2008 Jun;112(11):2500-8.PMID: 18386829 [PubMed - indexed for MEDLINE]
Is trastuzumab associated with adverse cardiac effects in patients with breast cancer?
Ewer MS, Lenihan DJ. Nat Clin Pract Oncol. 2008 Apr;5(4):192-3. Epub 2008 Jan 22. No abstract available. PMID: 18212766 [PubMed]Related articles
Left ventricular ejection fraction and cardiotoxicity: is our ear really to the ground?
Ewer MS, Lenihan DJ. J Clin Oncol. 2008 Mar 10;26(8):1201-3. Epub 2008 Jan 28. No abstract available. PMID: 18227525 [PubMed - indexed for MEDLINE]
Related articles
Prospective analysis of carotid artery flow in breast cancer patients treated with supraclavicular irradiation 8 or more years previously: no increase in ipsilateral carotid stenosis after radiation noted.
Woodward WA, Durand JB, Tucker SL, Strom EA, Perkins GH, Oh J, Arriaga L, Domain D, Buchholz TA. Cancer. 2008 Jan 15;112(2):268-73.PMID: 18000801 [PubMed - indexed for MEDLINE]
Reversibility of trastuzumab cardiotoxicity: is the concept alive and well?
Ewer MS, Tan-Chiu E. J Clin Oncol. 2007 Dec 1;25(34):5532-3; author reply 5533-4. No abstract available. PMID: 18048835 [PubMed - indexed for MEDLINE]
Related articles
Congestive heart failure is a rare event in patients receiving imatinib therapy.
Atallah E, Durand JB, Kantarjian H, Cortes J. Blood. 2007 Aug 15;110(4):1233-7. Epub 2007 Apr 20.PMID: 17449798 [PubMed - indexed for MEDLINE]
Impact of aspirin therapy in cancer patients with thrombocytopenia and acute coronary syndromes.
Sarkiss MG, Yusuf SW, Warneke CL, Botz G, Lakkis N, Hirch-Ginsburg C, Champion JC, Swafford J, Shaw AD, Lenihan DJ, Durand JB. Cancer. 2007 Feb 1;109(3):621-7.PMID: 17167763 [PubMed - indexed for MEDLINE]
Long-term cardiac tolerability of trastuzumab in metastatic breast cancer: the MD Anderson Cancer Center experience.
Guarneri V, Lenihan DJ, Valero V, Durand JB, Broglio K, Hess KR, Michaud LB, Gonzalez-Angulo AM, Hortobagyi GN, Esteva FJ. J Clin Oncol. 2006 Sep 1;24(25):4107-15. Epub 2006 Aug 14. Erratum in: J Clin Oncol. 2008 May 10;26(14): 2421. PMID: 16908934 [PubMed - indexed for MEDLINE]
Cardiotoxicity of the cancer therapeutic agent imatinib mesylate.
Kerkelä R, Grazette L, Yacobi R, Iliescu C, Patten R, Beahm C, Walters B, Shevtsov S, Pesant S, Clubb FJ, Rosenzweig A, Salomon RN, Van Etten RA, Alroy J, Durand JB, Force T. Nat Med. 2006 Aug;12(8):908-16. Epub 2006 Jul 23.PMID: 16862153 [PubMed - indexed for MEDLINE]
Late Breaking News
Key discovered to how chemotherapy drug causes heart failure. See News Release
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