The research activities in the department are centered on three general themes: nuclear function, cell regulation and embryo development. Our research employs a variety of technical approaches and experimental systems that represent the latest advances in biomedical science. We make use of a number of genetically important model organisms, including Drosophila, mice, yeast and bacteria. We also have state-of-the-art facilities for structural biology, chromatin remodeling, Drosophila genetics, embryonic stem cells and genetically engineered mice, confocal microscopy and a host of other resources readily available to all our researchers. Our underlying rationale is that a deep understanding of cancer and many other diseases can only be achieved by addressing the basic mechanistic features associated with normal cells and tissues.
As a basic science department in a world-renowned cancer center, we are strong advocates for a continued commitment to fundamental research in biology. At the same time, we actively encourage and nurture productive interactions with translational and clinical researchers in the hope that our basic discoveries will eventually lead to clinical applications.