Lab Members
Shao-Cong Sun, Ph.D.
Professor & Deputy Chair, Immunology department
Director, Center for Inflammation and Cancer (CIC)
Moshe Talpaz
Endowed Chair in Immunology
ssun@mdanderson.org
Mikyoung Chang
Visiting Scientist
mikchang@mdanderson.org
My research interests lie in ubiquitin-dependent signaling that regulates inflammatory responses. I am currently studying how ubiquitination regulates the pathogenesis of experimental autoimmune encephalomyelitis, an animal model of the autoimmune neuroinflammatory disease multiple sclerosis.
Xuhong Cheng
Research Laboratory Coordinator
xhcheng@mdanderson.org
Meidi Gu
Postdoctoral Fellow
MGu2@mdanderson.org
My research interests are in immune metabolism and anti-tumor immunity. My current project focuses on elucidating the crosstalk between antigen receptor signaling and metabolic regulation in T cells.
Zuliang Jie
Postdoctoral Fellow
ZJie@mdanderson.org
My research interest is in mucosal immunology and innate immunity. My ongoing project is to study the role of non-canonical NF-kB signaling pathway in regulating mucosal dendritic cell function, intestine homeostasis and immunity.
Donghyun Joo
Postdoctoral Fellow
DJoo@mdanderson.org
I have been studying the molecular regulation of immune cell function and cancer cell characteristics. I am currently focusing on studies of Immune cell function in inflammation. I am also evaluating the potential of small molecule inhibitors as therapeutic agents for lung cancer.
Visiting Student
My research interest is in innate immunity and inflammation. My current project is focused on the characterization of novel factors regulating macrophage activation and inflammatory responses.
Yanchuan Li
Postdoctoral Fellow
YLi31@mdanderson.org
Noncanonical pathway has been implicated in regulating different aspects of immune functions. Recently, dysfunction of this pathway has also been associated with various autoimmune and inflammatory diseases as well as human malignancies. My research interests are in signalling mechanisms and the biological function of the non-canonical NF-κB pathway, which may provide new opportunities for therapeutic strategies.
Hui Wang
Postdoctoral Fellow
HWang22@mdanderson.org
Xiaoping Xie
Postdoctoral Fellow
XXie5@mdanderson.org
My research interests focus on molecular mechanisms regulating T cell functions in inflammation, autoimmunity, and cancer immunity. Currently, I am working on T cell regulation by cell-intrinsic mechanisms and dendritic cells.
Jin-Young Yang
Postdoctoral Fellow
JYang13@mdanderson.org
I have been studying host immune responses against infections and
other agents (e.g. nutrients, stress factors) especially in the
intestinal mucosa. My ongoing project is to clarify the role of
intestinal epithelial cell (IEC)-intrinsic NF-kB signaling in
intestinal inflammation and tumor development, aiming at obtaining new
insights for improving therapeutic approaches in colorectal cancer
prevention and treatment.
Yu Zheng
Visiting Scientist
YZheng3@mdanderson.org
My research interests are in the ubiquitin-dependent signaling mechanism that regulate innate immune cell activation and inflammation. My current project focuses on the study of how deubiquitinases regulate intestinal inflammation.
Xiaofei Zhou
Instructor
xiazhou@mdanderson.org
I have been studying T cell immune responses for the past several years and made a number of major contributions, including seminal findings regarding how non-canonical NF-kB regulates T-cell homeostasis, activation and development of autoimmune inflammatory diseases. I have also elucidated TCR rearrangement in conventional T cell and iNKT responses. My recent work demonstrated how T cell metabolism regulates autoimmunity. My ongoing research focuses on the understanding of ubiquitin-dependent signaling pathways in the regulation of T cell homeostasis and anti-tumor responses.
Le-Le Zhu
Postdoctoral Fellow
LZhu6@mdanderson.org
My research focuses on the molecular and cellular mechanisms regulating T lymphocyte activation and immune responses. These studies will advance our understanding of T cell signaling with the aim of identifying new therapeutic targets for autoimmune disorders and cancer immunotherapy.