Xuhong Cheng, Heart of MD Anderson recipient
2017 Jeffrey Lee Cousins Fellow in Lung Cancer Research
My research interest is in mucosal immunology and innate immunity. My ongoing project is to study the role of non-canonical NF-kB signaling pathway in regulating mucosal dendritic cell function, intestine homeostasis and immunity.
My research interest is in innate immunity and inflammation. My current project is focused on the characterization of novel factors regulating macrophage activation and inflammatory responses.
My research focuses on the roles of protein ubiquitination in regulating immune responses and inflammation. I am currently studying the function of a ubiquitin ligase in regulating inflammasome activation and T cell responses.
Noncanonical pathway has been implicated in regulating different aspects of immune functions. Recently, dysfunction of this pathway has also been associated with various autoimmune and inflammatory diseases as well as human malignancies. My research interests are in signalling mechanisms and the biological function of the non-canonical NF-κB pathway, which may provide new opportunities for therapeutic strategies.
My research interests focus on molecular mechanisms regulating T cell functions in inflammation, autoimmunity, and cancer immunity. Currently, I am working on T cell regulation by cell-intrinsic mechanisms and dendritic cells.
I have been studying T cell immune responses for the past several years and made a number of major contributions, including seminal findings regarding how non-canonical NF-kB regulates T-cell homeostasis, activation and development of autoimmune inflammatory diseases. I have also elucidated TCR rearrangement in conventional T cell and iNKT responses. My recent work demonstrated how T cell metabolism regulates autoimmunity. My ongoing research focuses on the understanding of ubiquitin-dependent signaling pathways in the regulation of T cell homeostasis and anti-tumor responses.
Lavoy Moore Endowment Fund for Lung Cancer Research
My research focuses on the molecular and cellular mechanisms regulating T lymphocyte activation and immune responses. These studies will advance our understanding of T cell signaling with the aim of identifying new therapeutic targets for autoimmune disorders and cancer immunotherapy.